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The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease
BackgroundRNA editing at the Q/R site of GluA2 occurs with ~99% efficiency in the healthy brain, so that the majority of AMPARs contain GluA2(R)...
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The interaction between cannabis use and a CB1-related polygenic co-expression index modulates dorsolateral prefrontal activity during working memory processing
Convergent findings indicate that cannabis use and variation in the cannabinoid CB1 receptor coding gene ( CNR1 ) modulate prefrontal function during...
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Musical Mnemonics in Cognitively Unimpaired Individuals and Individuals with Alzheimer’s Dementia: A Systematic Review
Based on the idea that music acts as a mnemonic aid, musical mnemonics (i.e., sung presentation of information, also referred to as ‘music as a...
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Neural correlates of maintenance working memory, as well as relevant structural qualities, are associated with earlier antiretroviral treatment initiation in vertically transmitted HIV
There is evidence of HIV affecting cognitive functioning across age groups, with adult studies showing related deficits in frontostriatal and...
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Correlations between cerebrospinal fluid biomarkers, neurocognitive tests, and resting-state electroencephalography (rsEEG) in patients with HIV-associated neurocognitive disorders
HIV-associated neurocognitive disorders (HAND) are highly prevalent in people living with HIV (PLWH) despite successful treatment with combination...
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Effects of transcranial direct current stimulation on brain changes and relation to cognition in patients with schizophrenia: a fMRI study
We studied brain changes during an N-back task before and after 10 sessions of transcranial direct current stimulation (tDCS) and its relation to...
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Effects of psychotherapy on brain activation during negative emotional processing in patients with posttraumatic stress disorder: a systematic review and meta-analysis
Post-traumatic stress disorder (PTSD) is a debilitating condition which has been related to problems in emotional regulation, memory and cognitive...
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Expression Patterns of miRNAs in Egyptian Children with ADHD: Clinical Study with Correlation Analysis
ADHD has huge knowledge gaps concerning its etiology. MicroRNAs (miRNAs) provide promising diagnostic biomarkers of human pathophysiology and may be...
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Glutamatergic response to a low load working memory paradigm in the left dorsolateral prefrontal cortex in patients with mild cognitive impairment: a functional magnetic resonance spectroscopy study
Working memory deficits have been widely reported in mild cognitive impairment (MCI). However, the neural mechanisms of working memory dysfunction in...
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Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by the accumulation of the tau protein in neurons, neurodegeneration and memory loss. However, the role of...
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Neurofeedback training of executive function in autism spectrum disorder: distinct effects on brain activity levels and compensatory connectivity changes
BackgroundDeficits in executive function (EF) are consistently reported in autism spectrum disorders (ASD). Tailored cognitive training tools, such...
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3D Visualization of Whole Brain Vessels and Quantification of Vascular Pathology in a Chronic Hypoperfusion Model Causing White Matter Damage
Chronic cerebral hypoperfusion is an important pathological factor in many neurodegenerative diseases, such as cerebral small vessel disease (CSVD)....
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Effects of Neonatal Administration of Memantine on Hippocampal Asymmetry and Working Memory Impairment Induced by Early Maternal Deprivation in Rats
Schizophrenia is manifested with abnormalities in working memory and in exaggerated asymmetry of the hippocampus, basal ganglia, and temporoparietal...
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A tale of two gradients: differences between the left and right hemispheres predict semantic cognition
Decomposition of whole-brain functional connectivity patterns reveals a principal gradient that captures the separation of sensorimotor cortex from...
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Matured hop bitter acids improve spatial working and object recognition memory via nicotinic acetylcholine receptors
RationaleCognitive decline and dementia are major concerns in today’s aging society. As limited treatments are available, measures to prevent...
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Task effects on functional connectivity measures after stroke
Understanding the effect of task compared to rest on detecting stroke-related network abnormalities will inform efforts to optimize detection of such...
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The fMRI correlates of visuo-spatial abilities: sex differences and gender dysphoria
The contribution of brain regions to visuospatial abilities according to sex differences and gender identity is inconsistently described. One...
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What is the contribution of executive functions to communicative-pragmatic skills? Insights from aging and different types of pragmatic inference
The role of executive functions in supporting the pragmatics of communication has been extensively examined in clinical populations, but is still...
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The Use of Touchscreen-Based Methods to Characterize Effects of Psychoactive Drugs on Executive Function in Nonhuman Primates
Purpose of ReviewThis review describes studies that assessed the acute and chronic effects of commonly consumed drugs on executive function, with a...
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Correlation of Cognitive Reappraisal and the Microstructural Properties of the Forceps Minor: A Deductive Exploratory Diffusion Tensor Imaging Study
Cognitive reappraisal (CR) is a mechanism for emotion regulation, and the prefrontal cortex (PFC) plays a central role in the regulation of emotions....
