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Non-coding RNAs in pancreatic cancer: challenges and opportunities for clinical application
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a dismal prognosis for which new therapeutic strategies are desperately...
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PIM Kinases in AML
PIM proto-oncogenes encode for a family of serine/threonine/tyrosine kinases (Pim-1, Pim-2 and Pim-3) that are overexpressed in a number of solid...
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Targeting the Pim kinases in multiple myeloma
Multiple myeloma (MM) is a plasma cell malignancy that remains incurable. Novel treatment strategies to improve survival are urgently required. The...
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Intracellular calcium regulates nonsense-mediated mRNA decay
The nonsense-mediated mRNA decay (NMD) pathway selectively eliminates aberrant transcripts containing premature translation termination codons and...
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The Therapeutic Role of MicroRNAs in Human Gliomas
Gliomas represent more than a quarter of central nervous system tumors and the vast majority of all malignant brain tumors. Patients diagnosed with a...
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Low-Dose Candesartan Enhances Molecular Mediators of Neuroplasticity and Subsequent Functional Recovery After Ischemic Stroke in Rats
We have previously reported that angiotensin type 1 receptor (AT1R) blockade with candesartan exerts neurovascular protection after experimental...
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Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice
Redox imbalance in the brain significantly contributes to ischemic stroke pathogenesis, but antioxidant therapies have failed in clinical trials....
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Differential expression of Pim-3, c-Myc, and p-p27 proteins in adenocarcinomas of the gastric cardia and distal stomach
Gastric cardia adenocarcinoma (GCA) is distinct from adenocarcinoma of the distal stomach because of its different etiological factors, tumor...
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Exploiting Cell Cycle Pathways in Cancer Therapy: New (and Old) Targets and Potential Strategies
There is a now a large body of evidence supporting the notion that cancer cells have vastly altered cell cycle networks that serve to maintain their...
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The Anorectic Phenotype of the anx/anx Mouse Is Related to Hypothalamic Dysfunction
The anorectic anx/anx mouse, characterized by reduced food intake, is an interesting and useful model for studies of mechanisms involved in the...
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Inhibition of Pim2-prolonged skin allograft survival through the apoptosis regulation pathway
Recently, apoptosis has been considered to be an important regulator for allograft survival. The serine/threonine kinase Pim2 has been implicated in...
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PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma
Background:PIM serine/threonine kinases are often highly expressed in haematological malignancies. We have shown that PIM inhibitors reduced the...
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Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?
BackgroundPsychological stress, particularly in chronic form, can lead to mood and cognitive dysfunction and is a major risk factor in the...
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Viruses with a Double-Stranded DNA Genome
There are many viruses with a double-stranded DNA genome that are known to infect mammals. They are subdivided into seven virus families:...
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For better or for worse: the role of Pim oncogenes in tumorigenesis
Pim oncogenes are overexpressed in a wide range of tumours from a haematological and epithelial origin. Pim genes encode serine/threonine kinases...
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15 kDa Granulysin versus GM-CSF for monocytes differentiation: analogies and differences at the transcriptome level
BackgroundGranulysin is an antimicrobial and proinflammatory protein with several isoforms. While the 9 kDa isoform is a well described cytolytic...
