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The role of natural killer cells in liver inflammation
The liver is an important immunological site that can promote immune tolerance or activation. Natural killer (NK) cells are a major immune subset...
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Uncovering the cellular and omics characteristics of natural killer cells in the bone marrow microenvironment of patients with acute myeloid leukemia
BackgroundAcute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy and the most frequently acute leukemia of stem cell...
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Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy
Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is now evident that TDEs also favor tumor growth by...
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Ex vivo expanded allogeneic natural killer cells have potent cytolytic activity against cancer cells through different receptor-ligand interactions
BackgroundRecently, allogeneic natural killer (NK) cells have gained considerable attention as promising immunotherapeutic tools due to their unique...
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Fusogenic vesicular stomatitis virus combined with natural killer T cell immunotherapy controls metastatic breast cancer
BackgroundMetastatic breast cancer is a leading cause of cancer death in woman. Current treatment options are often associated with adverse side...
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Delivery technologies to engineer natural killer cells for cancer immunotherapy
In recent years, immune cell-based cancer therapeutics have been utilized broadly in the clinic. Through advances in cellular engineering, chimeric...
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The Role of Cytokines in Maintaining the Dynamics of Cell—Cell Interaction between Natural Killer Cells and Trophoblast Cells
We analyzed the effect of individual cytokines that are secretory products of placenta typical of the uteroplacental bed. The proinflammatory...
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Brain endothelial CXCL12 attracts protective natural killer cells during ischemic stroke
BackgroundThe innate lymphoid cell (ILC) family consists of NK cells, ILC type 1, 2, 3 and lymphoid tissue inducer cells. They have been shown to...
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A general toxicity and biodistribution study of human natural killer cells by single or repeated intravenous dose in severe combined immune deficient mice
Natural killer (NK) cells are a part of the innate immune system and represent the first line of defense against infections and tumors. NK cells can...
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Determining Activation Status of Natural Killer Cells Following Stimulation via Cytokines and Surface Receptors
Stimulation of Natural Killer (NK) cells with cytokines, target cell interaction, or antibody mediated activation of receptors on the NK cell surface...
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Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma
BackgroundExtranodal natural killer/T-cell lymphoma (NKTL) is an aggressive type of non-Hodgkin lymphoma with dismal outcome. A better understanding...
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Natural Killer Cell Defects
Natural killer (NK) cells are innate lymphocytes that play an essential role in immune defense against viral infections and in tumor surveillance....
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CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma
BackgroundGlioblastoma (GBM) is the most common malignant brain tumor and has “immunologically cold” features. Changing GBM to an “immunologically...
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Lipid Metabolism in Tumor-Associated Natural Killer Cells
Accumulative data demonstrate that during the initiation and progression of tumors, several types of cellular components in tumor microenvironment,...
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In Vitro Visualization of Cell-to-Cell Interactions Between Natural Killer Cells and Sensory Neurons
Cell-to-cell interactions between the immune and nervous systems are increasingly recognized for their importance in health and disease. Assessment...
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Biology and pathology of the uterine microenvironment and its natural killer cells
Tissues are the new frontier of discoveries in immunology. Cells of the immune system are an integral part of tissue physiology and immunity....
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Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients
BackgroundMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious disorder of unknown aetiology. While the pathomechanism of ME/CFS...
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Purification of Primary Decidual Natural Killer Cells for Functional Analysis
Decidual NK cells (dNK) are a unique type of NK cells found at the maternal–fetal interface during pregnancy. dNK play a key role in placental...
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Natural Killer Cell Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity Against Plasmodium falciparum-Infected Red Blood Cells
Antibody-dependent cellular cytotoxicity (ADCC) is a mechanism of cell defense that bridges the innate and adaptive immune systems. ADCC has been...
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Multifaceted characterization of the biological and transcriptomic signatures of natural killer cells derived from cord blood and placental blood
BackgroundPerinatal blood including umbilical cord blood and placental blood are splendid sources for allogeneic NK cell generation with high...
