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Decreased Frequency and Function of Circulating Plasmocytoid Dendritic Cells (pDC) in Hepatitis B Virus Infected Humans
The Type 2 precusor plasmacytoid dendritic cells (pDC) represent the most important cell type in antiviral innate immunity. To understand the...
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Hypoxic gene expression and metastasis
Solid tumors possess malformed vasculature that results in the exposure of tumor cells to a low oxygen environment. Tumor hypoxia has been...
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Immunology of hepatitis B virus
Hepatitis B virus (HBV) is perceived as a principally hepatotropic virus that causes liver disease ranging from an apparent absence of symptoms [i.e....
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The Genetics of Cancer: The Indian Subcontinent Perspective
The cancer is global and undoubtedly one of the major causes of mortality and morbidity irrespective of geographic and ethnic origin. It equally...
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Hypoxia-induced angiogenesis in human hepatocellular carcinoma
Hepatocellular carcinoma is a typical hypervascular tumor. Generally, hepatocellular carcinoma is developed through liver cirrhosis induced by...
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Frequent genomic imbalances suggest commonly altered tumour genes in human hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is one of the most frequent-occurring malignant tumours worldwide, but molecular changes of tumour DNA, with the...
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Molecular profiles of BRCA1-mutated and matched sporadic breast tumours: relation with clinico-pathological features
About 5–10% of breast cancers are hereditary; a genetically and clinically heterogeneous disease in which several susceptibility genes, including...
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The Tumor Necrosis Factor-α Converting Enzyme
Tumor necrosis factor (TNF)-α is a potent pro-inflammatory agent produced primarily by activated monocytes and macrophages (VASSALLI 1992)....
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Hepatoma-specific antitumor activity of an albumin enhancer/promoter regulated herpes simplex virus in vivo
Targeting viral vectors to appropriate cell types so that normal cells are not adversely affected is an important goal for gene therapy. Previously,...
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Current Status of Antiviral Therapy for Chronic Hepatitis C
Hepatitis C virus (HCV) was first identified in the late 1980s, and soon thereafter was shown to be the cause of almost all cases of non-B...
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Therapy for Chronic Hepatitis B Infection
There are many parallels between hepatitis B virus (HBV) infection and that of human immunodeficiency virus (HIV). HBV is a partially double-stranded...
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The Viruses
This report describes the taxa and member viruses approved by the ICTV between 1970 and 1993. Descriptions of the most important characteristics of...
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Hepatitis B virus C-gene variants
The heterogeneity of hepatitis B virus (HBV) is increasingly believed to play a role in viral persistence, pathogenesis, and the type of response to...
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Implications of genetic variation on the pathogenesis of hepatitis B virus infection
It is now well established that sequence variation of hepatitis B virus (HBV) occurs worldwide. Although variants have been classified into subtypes...
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Human chromosome 19 contains the neurotrophin-5 gene locus and three related genes that may encode novel acidic neurotrophins
Differentiation, survival, and function of the vertebrate neurons are controlled by multiple, target-derived neurotrophic factors. The best...
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Target cells for 1,25 dihydroxyvitamin D3 in the pancreas
Mature rats raised on a vitamin D deficient diet were injected with tritium labeled 1,25 dihydroxyvitamin D 3 . Concentration of radioactivity, which...