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Piperlongumine, a piper alkaloid, enhances the efficacy of doxorubicin in breast cancer: involvement of glucose import, ROS, NF-κB and lncRNAs
Piperlongumine (PL, piplartine) is an alkaloid derived from the Piper longum L. (long pepper) roots. Originally discovered in 1961, the biological...
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General Strategies for Rational Design and Discovery of Multitarget Drugs
The first step for drug discovery and development is to choose a right or optimal strategy to begin with. This is more so for rational design of...
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Comparison of Therapeutic Efficacy of Nanoformulations of Curcumin vs Tetrahydrocurcumin in Various Disorders
The purpose of this chapter is to consolidate the existing data on nanoformulation(s) of two folklore molecules, curcumin and tetrahydrocurcumin...
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Multifunctional lipidic nanocarriers for effective therapy of glioblastoma: recent advances in stimuli-responsive, receptor and subcellular targeted approaches
BackgroundGlioblastoma, or glioblastoma multiforme (GBM), remains a fatal cancer type despite the remarkable progress in understanding the genesis...
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The Emerging Role of Natural Products in Cancer Treatment
The exploration of natural products as potential agents for cancer treatment has garnered significant attention in recent years. In this...
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Notch Pathway: A Journey from Notching Phenotypes to Cancer Immunotherapy
Notch is a key evolutionary conserved pathway, which has fascinated and engaged the work of investigators in an uncountable number of biological...
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Homing Peptides for Cancer Therapy
Tumor-homing peptides are widely used for improving tumor selectivity of anticancer drugs and imaging agents. The goal is to increase tumor uptake...
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Design and synthesis of ludartin derivatives as potential anticancer agents against hepatocellular carcinoma
Our previous study demonstrated that guaiane-type sesquiterpenoid ludartin showed potent antihepatoma activity against two human hepatocellular...
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BTK targeting suppresses inflammatory genes and ameliorates insulin resistance
Type 2 diabetes (T2D) causes profound psychological and physical distress to patients and burdens the health-care system. Although several...
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A Practical Guide to miRNA Target Prediction
MicroRNAs (miRNAs) are small endogenous noncoding RNA molecules that posttranscriptionally regulate gene expression. Since their discovery, a huge...
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Exploration of interaction scoring criteria in the CANDO platform
ObjectiveAscertain the optimal interaction scoring criteria for the Computational Analysis of Novel Drug Opportunities (CANDO) platform for shotgun...
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In Vitro Assays for Assessing Potential Adverse Effects of Cancer Immunotherapeutics
The field of cancer immunotherapy (CIT) covers a wide and ever-growing variety of molecular platforms and modalities. Since the overall aim of CIT is...
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Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance
The tumor microenvironment (TME) plays a pivotal role in cancer development and progression. In this line, revealing the precise mechanisms of the...
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Natural compounds targeting nuclear receptors for effective cancer therapy
Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate gene expression both spatially and temporally. Numerous...
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Thymoquinone-chemotherapeutic combinations: new regimen to combat cancer and cancer stem cells
Cancer is a worldwide disease that causes millions of cases of mortality and morbidity. The major problem associated with the cancer is its...
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Genetic engineering of T cells for immunotherapy
Genetically engineered T cell immunotherapies have provided remarkable clinical success to treat B cell acute lymphoblastic leukaemia by harnessing a...
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Soluble ligands as drug targets
Historically, the main classes of drug targets have been receptors, enzymes, ion channels and transporters. However, owing largely to the rise of...
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ACT001 modulates the NF-κB/MnSOD/ROS axis by targeting IKKβ to inhibit glioblastoma cell growth
AbstractGlioblastomas are high-grade brain tumors with poor prognoses, and new therapeutic approaches for these tumors are critically needed. This...
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Immune precision medicine for cancer: a novel insight based on the efficiency of immune effector cells
Cancer cell growth is associated with immune surveillance failure. Nowadays, restoring the desired immune response against cancer cells remains a...
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Inhibition of Tumor Angiogenesis in the Treatment of Lung Cancer
Several anti-angiogenic drugs have been investigated in patients with thoracic malignancies. In patients with advanced, non-squamous, non-small-cell...