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Aminochrome Induces Neuroinflammation and Dopaminergic Neuronal Loss: A New Preclinical Model to Find Anti-inflammatory and Neuroprotective Drugs for Parkinson’s Disease
AbstractStudies have suggested aminochrome as an endogenous neurotoxin responsible for the dopaminergic neuron degeneration in Parkinson’s disease...
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Impact of Sleep Deprivation on Major Neuroinflammatory Signal Transduction Pathways
Sleep deprivation (SD) is emulating an epidemic imparting detrimental effects ranging from immediate repercussions like vehicle accidents to very...
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Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep
BackgroundIncreased systemic and tissue levels of interleukin (IL)-1β are associated with greater risk of impaired neurodevelopment after birth. In...
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Partial Ablation of Astrocytes Exacerbates Cerebral Infiltration of Monocytes and Neuronal Loss After Brain Stab Injury in Mice
In traumatic brain injury (TBI), mechanical injury results in instantaneous tissue damages accompanied by subsequent pro-inflammatory cascades...
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Progesterone and Allopregnanolone Neuroprotective Effects in the Wobbler Mouse Model of Amyotrophic Lateral Sclerosis
Progesterone regulates a number of processes in neurons and glial cells not directly involved in reproduction or sex behavior. Several...
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Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
The pathology of familial Alzheimer’s disease, which is caused by dominant mutations in the gene that encodes amyloid-beta precursor protein (APP)...
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Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD
BackgroundAlthough ɑ-synuclein (ɑ-syn) spreading in age-related neurodegenerative diseases such as Parkinson’s disease (PD) and Dementia with Lewy...
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AAV-Mediated Artificial miRNA Reduces Pathogenic Polyglucosan Bodies and Neuroinflammation in Adult Polyglucosan Body and Lafora Disease Mouse Models
Adult polyglucosan body disease (APBD) and Lafora disease (LD) are autosomal recessive glycogen storage neurological disorders. APBD is caused by...
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E2F4-Based Gene Therapy Mitigates the Phenotype of the Alzheimer’s Disease Mouse Model 5xFAD
After decades of unfruitful work, no effective therapies are available for Alzheimer’s disease (AD), likely due to its complex etiology that requires...
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Repurposing Pomalidomide as a Neuroprotective Drug: Efficacy in an Alpha-Synuclein-Based Model of Parkinson’s Disease
Marketed drugs for Parkinson’s disease (PD) treat disease motor symptoms but are ineffective in stop** or slowing disease progression. In the quest...
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Microbial pathogens induce neurodegeneration in Alzheimer’s disease mice: protection by microglial regulation
BackgroundNeurodegeneration is considered the consequence of misfolded proteins’ deposition. Little is known about external environmental effects on...
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Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
BackgroundProgression of Alzheimer’s disease leads to synapse loss, neural network dysfunction and cognitive failure. Accumulation of protein...
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Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis
BackgroundAlzheimer’s disease (AD) is an incurable neurodegenerative disorder characterised by the progressive buildup of toxic amyloid-beta (Aβ) and...
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Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice
One of the main pathological hallmarks of Alzheimer’s disease (AD) is the intraneuronal accumulation of hyperphosphorylated tau. Passive...
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A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice
Alzheimer’s disease (AD) has a complex etiology, which requires a multifactorial approach for an efficient treatment. We have focused on E2 factor 4...
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Melatonin ameliorates spatial memory and motor deficits via preserving the integrity of cortical and hippocampal dendritic spine morphology in mice with neurotrauma
We aimed to elucidate the role of cortical and hippocampal dendritic spines on neurological deficits associated with hippocampal microgliosis,...
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Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain
Abdominal pain is one of the main symptoms of chronic gastrointestinal disorders including inflammatory bowel diseases (IBD) and irritable bowel...
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Flavonoids: A Promising Neuroprotectant and Its Salutary Effects on Age-Related Neurodegenerative Disorders
Neurodegenerative disorders have become one of the most serious threats to global civilization in recent years. According to present data and future...
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Interleukin-6-elicited chronic neuroinflammation may decrease survival but is not sufficient to drive disease progression in a mouse model of Leigh syndrome
BackgroundMitochondrial diseases (MDs) are genetic disorders characterized by dysfunctions in mitochondria. Clinical data suggest that additional...
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The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation
Apolipoprotein E4 ( APOE4 ) is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD), leading to earlier age of clinical onset...
