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Detection of Antigen Presentation by Murine Bone Marrow–Derived Dendritic Cells After Treatment with Nanoparticles
Nanoparticles are frequently considered in vaccine applications due to their ability to co-deliver multiple antigens and adjuvants to...
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Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment
Pluripotent stem cells (PSCs) are a promising source of allogeneic T cells for off-the-shelf immunotherapies. However, the process of differentiating...
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Neoself Antigens Presented on MHC Class II Molecules in Autoimmune Diseases
Major histocompatibility complex (MHC) class II molecules play a crucial role in immunity by presenting peptide antigens to helper T cells. Immune...
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CD4+ T cell memory
Specialized subpopulations of CD4 + T cells survey major histocompatibility complex class II–peptide complexes to control phagosomal infections, help...
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An expanding horizon of complex injectable products: development and regulatory considerations
There has been a constant evolution in the pharmaceutical market concerning the new technologies imbibed in delivering drug substances for various...
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Central nervous system-associated macrophages modulate the immune response following stroke in aged mice
Age is a major nonmodifiable risk factor for ischemic stroke. Central nervous system-associated macrophages (CAMs) are resident immune cells located...
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Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
BackgroundParkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn)...
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Calreticulin: a quintessential multifaceted protein with therapeutic potential
Calreticulin is primarily an endoplasmic reticulum (ER) resident protein which has also been identified at different cellular sites. Its...
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LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation
LAG3 is an inhibitory receptor that is highly expressed on exhausted T cells. Although LAG3-targeting immunotherapeutics are currently in clinical...
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Rational immunosilencing of a promiscuous T-cell epitope in the capsid of an adeno-associated virus
Owing to the immunogenicity of adeno-associated viruses (AAVs), gene therapies using AAVs face considerable obstacles. Here, by leveraging ex vivo...
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A novel 4 immune-related genes as diagnostic markers and correlated with immune infiltrates in major depressive disorder
BackgroundImmune response is prevalently related with major depressive disorder (MDD) pathophysiology. However, the study on the relationship between...
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The complex role of tumor-infiltrating macrophages
Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and immune defense against pathogens, macrophages are being...
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Blockade of histamine receptor H1 augments immune checkpoint therapy by enhancing MHC-I expression in pancreatic cancer cells
BackgroundAlthough immune checkpoint blockade (ICB) therapy has proven to be extremely effective at managing certain cancers, its efficacy in...
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I-Ag7 β56/57 polymorphisms regulate non-cognate negative selection to CD4+ T cell orchestrators of type 1 diabetes
Genetic susceptibility to type 1 diabetes is associated with homozygous expression of major histocompatibility complex class II alleles that carry...
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Imputation-Based HLA Ty** with GWAS SNPs
SNP-based imputation approaches for human leukocyte antigen (HLA) ty** take advantage of the haplotype structure within the major...
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The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis
Antigen-specific memory CD4 + T cells can persist and confer rapid and efficient protection from microbial reinfection. However, the mechanisms...
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Characterization of T-Cell Epitopes in Food Allergens by Bioinformatic Tools
The identification of T-cell epitopes is a critical step in the understanding of the immunologic mechanisms such as food allergy. Epitope screening...
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Detecting associated genes for complex traits shared across East Asian and European populations under the framework of composite null hypothesis testing
BackgroundDetecting trans-ethnic common associated genetic loci can offer important insights into shared genetic components underlying complex...
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Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology
Intestinal epithelial cell (IEC) damage by T cells contributes to graft-versus-host disease, inflammatory bowel disease and immune checkpoint...
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Quantitative proteomic analysis of local and systemic extracellular vesicles during Eimeria falciformis infectious cycle in the host
BackgroundExtracellular vesicles (EVs) are membranous structures that are formed during pathophysiology, host-parasite interactions and parasite...
