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Transcriptome analysis reveals the neuroprotective effect of Dlg4 against fastigial nucleus stimulation-induced ischemia/reperfusion injury in rats
BackgroundPrevious studies have demonstrated that electrical stimulation of the cerebellar fastigial nucleus (FNS) can considerably decrease...
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DNA-methylation-mediated activating of lncRNA SNHG12 promotes temozolomide resistance in glioblastoma
BackgroundAccumulating evidence shows that long noncoding RNAs (lncRNAs) are important regulator molecules involved in diverse biological processes....
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Autophagy in Mesenchymal Stem Cell-Based Therapy
Mesenchymal stem cellsMesenchymal stem cells (MSC)" (MSCs) are adult stem cells which are, due to their huge differentiation potential, potent...
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Synthetic Chemicals: What We Have Learned and Still Need to Learn About Their Associations with Childhood Allergy and Asthma
Purpose of ReviewPrenatal and childhood exposure to synthetic chemicals, such as phenols and phthalates, have been linked to asthma and allergy, but...
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Dense module searching for gene networks associated with multiple sclerosis
BackgroundMultiple sclerosis (MS) is a complex disease in which the immune system attacks the central nervous system. The molecular mechanisms...
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Molecular Network Mechanism Analysis of Urine Stem Cells Against Retinal Aging
To investigate the effect and potential mechanism of human-derived urine stem cells (hUSCs) in inhibiting retinal aging by using experimental and...
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miR194 hypomethylation regulates coronary artery disease pathogenesis
Coronary artery disease (CAD) is one of the most common heart diseases, characterized by the hardening and narrowing of arteries, resisting blood...
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Emerging roles of circular RNAs in tumorigenesis, progression, and treatment of gastric cancer
With an estimated one million new cases reported annually, gastric cancer (GC) ranks as the fifth most diagnosed malignancy worldwide. The early...
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Hsa_circ_0004872 mitigates proliferation, metastasis and immune escape of meningioma cells by suppressing PD-L1
Meningioma is a prevalent intracranial malignancy known for its aggressive growth. Circular RNAs (circRNAs) play a crucial role in the development of...
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Nuplazid suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting PAK4
BackgroundDue to the high recurrence and low 5-year survival rates of esophageal squamous cell carcinoma (ESCC) after treatment, the discovery of...
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Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
BackgroundGenetic variation at the PTK2B locus encoding the protein Pyk2 influences Alzheimer’s disease risk. Neurons express Pyk2 and the protein...
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A novel role of follicle-stimulating hormone (FSH) in various regeneration-related functions of endometrial stem cells
Follicle-stimulating hormone (FSH) promotes the production and secretion of estrogen, which in turn stimulates the growth and maturation of ovarian...
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Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway
Bavachinin (BVC) is a natural small molecule from the Chinese herb Fructus Psoraleae. It exhibits numerous pharmacological effects, including...
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Exploring gene network and protein interaction analysis of neurotrophin signaling pathway in ameloblastoma
Ameloblastoma is a non-cancerous but aggressive oral tumor emerging from odontogenic epithelial tissue involved during odontogenesis. Since there is...
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Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by genomic aberrations in oncogenes, cytogenetic abnormalities, and an aberrant...
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Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing
Inflammatory pain, sustained by a complex network of inflammatory mediators, is a severe and persistent illness affecting many of the general...
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Identification and validation of ferroptosis-related genes in patients infected with dengue virus: implication in the pathogenesis of DENV
Ferroptosis, an iron-dependent form of regulated cell death, has been associated with many virus infections. However, the role of ferroptosis in...
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Clinical application of chromosomal microarray analysis for fetuses with craniofacial malformations
BackgroundThe potential correlations between chromosomal abnormalities and craniofacial malformations (CFMs) remain a challenge in prenatal...
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MicroRNAs and Cancer Signaling Pathways
Cancer is a condition where cells have gained the capability, generally due to genetic abnormalities in certain genes, of uncontrolled divisions and...
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Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas
Circular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a 5’ end cap and a 3’ end poly (A) tail necessary for...
