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Sphingolipids and Cholesterol
Sphingolipids and cholesterol are two lipid partners on cellular membranes where they form specific microdomains, named lipid rafts, which mediate...
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Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E
BackgroundSeveral lines of evidence suggest that high-density lipoprotein (HDL) reduces Alzheimer’s disease (AD) risk by decreasing vascular...
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Plasma exosome-derived microRNAs expression profiling and bioinformatics analysis under cross-talk between increased low-density lipoprotein cholesterol level and ATP-sensitive potassium channels variant rs1799858
BackgroundExosome-derived microRNAs (exo-miRs) as messengers play important roles, in the cross-talk between genetic [ATP-sensitive potassium...
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Poly(Butyl Cyanoacrylate) Nanoparticles Deliver β-Nerve Growth Factor to the Brain After Traumatic Brain Injury
Introduction Traumatic brain injury (TBI)Traumatic Brain Injury (TBI) is one of the main reasons for disability and death in patients. There is...
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Polygenic risk scores analyses of psychiatric and metabolic traits with antipsychotic-induced weight gain in schizophrenia: an exploratory study
Given the polygenic nature of antipsychotic-induced weight gain (AIWG), we investigated whether polygenic risk scores (PRS) for various psychiatric...
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Renin–Angiotensin–Aldosterone System and LOX-1 Interaction in Hypertension with a Focus on Modulation of the Immune System
The renin–angiotensin–aldosterone systemRenin-angiotensin-aldosterone system (RAAS) plays a key role in the pathological process of many...
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Comparison of the effects of empagliflozin and sitagliptin, as add-on to metformin, on serum levels of asprosin and metabolic parameters in patients with type 2 diabetes mellitus
The effect of sitagliptin and empagliflozin on serum levels of asprosin and metabolic parameters in patients with type 2 diabetes mellitus (T2DM) was...
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Increased Plasma Levels of Triglyceride-Enriched Lipoproteins Associate with Systemic Inflammation, Lipopolysaccharides, and Gut Dysbiosis in Common Variable Immunodeficiency
PurposeTriglycerides (TG) and their major transport lipoprotein in the circulation (VLDL) appear to be related to inflammation. Patients with common...
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Sex differences in cardiovascular risk, lifestyle, and psychological factors in patients with type 2 diabetes: the Fukuoka Diabetes Registry
BackgroundThe excess risk of cardiovascular diseases associated with diabetes is greater in women than in men. The present study aimed to examine sex...
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Effects of levothyroxine replacement therapy on insulin resistance in patients with untreated primary hypothyroidism
ObjectivesThis study investigated the effects of levothyroxine replacement therapy on insulin resistance, lipid profile, and thyroid function in...
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Epigenetic aging in patients diagnosed with coronary artery disease: results of the LipidCardio study
IntroductionPeople age biologically at different rates. Epigenetic clock-derived DNA methylation age acceleration (DNAmAA) is among the most...
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Evaluation of levels of uric acid and lipid profile in hospitalized patients with diabetes
ObjectiveDiabetes is the most common metabolic disorder that leads to various complications, and among these complications, disruption in the lipid...
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Association between lipoprotein(a) (Lp(a)) levels and Lp(a) genetic variants with coronary artery calcification
BackgroundTo examine the association between lipoprotein(a) (Lp(a)) levels, LPA (rs10455872 and rs3798220) and IL1F9 (rs13415097) single nucleotide...
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Causal effects of serum lipid biomarkers on early age-related macular degeneration using Mendelian randomization
BackgroundAge-related macular degeneration (AMD) is one of the major causes of vision loss. Early AMD needs to be taken seriously, but the causal...
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Data-Independent Acquisition-Based Serum Proteomic Profiling of Adult Moyamoya Disease Patients Reveals the Potential Pathogenesis of Vascular Changes
Moyamoya disease (MMD) is a chronic cerebrovascular disease with unknown etiology. The pathogenesis of vascular changes remains unclear. Ischemic and...
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The effect of acarbose on lipid profiles in adults: a systematic review and meta-analysis of randomized clinical trials
PurposeDyslipidemia, characterized by elevated levels of triglycerides (TG), low-density lipoprotein (LDL), total cholesterol (TC), and reduced...
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Fibroblast growth factor 21 (FGF21) attenuates tacrolimus-induced hepatic lipid accumulation through transcription factor EB (TFEB)-regulated lipophagy
Tacrolimus (TAC), also called FK506, is one of the classical immunosuppressants to prevent allograft rejection after liver transplantation. However,...
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Prognostic importance of systemic inflammation and insulin resistance in patients with cancer: a prospective multicenter study
BackgroundSystemic inflammation and insulin resistance (IR) are often associated with poor prognosis in cancer. This study aimed to investigate the...
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Distinct effects of cholesterol profile components on amyloid and vascular burdens
BackgroundCholesterol plays important roles in β-amyloid (Aβ) metabolism and atherosclerosis. However, the relationships of plasma cholesterol levels...
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RNA interference targeting ANGPTL3 for triglyceride and cholesterol lowering: phase 1 basket trial cohorts
Elevated triglycerides and non-high-density lipoprotein cholesterol (HDL-C) are risk factors for atherosclerotic cardiovascular disease (ASCVD)....
