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Patient-reported burden of intensified surveillance and surgery in high-risk individuals under pancreatic cancer surveillance
In high-risk individuals participating in a pancreatic cancer surveillance program, worrisome features warrant for intensified surveillance or,...
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Pancreatic resection for intraductal papillary mucinous neoplasm– a thirteen-year single center experience
BackgroundThe purpose of this study is to review our results for pancreatic resection in patients with intraductal papillary mucinous neoplasm (IPMN)...
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The Molecular Pathology of Precursor Lesions of Pancreatic Cancer
It has become evident over the past decade that pancreatic ductal adenocarcinoma (PDAC) does not originate de novo, but rather, through a multistep...
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An elevated expression of serum exosomal microRNA-191, − 21, −451a of pancreatic neoplasm is considered to be efficient diagnostic marker
BackgroundPancreatic cancer is associated with an extremely poor prognosis, so new biomarkers that can detect the initial stages are urgently needed....
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The significance of exosomal RNAs in the development, diagnosis, and treatment of pancreatic cancer
Exosomes are single-membrane, secreted organelles with a diameter of 30–200 nm, containing diverse bioactive constituents, including DNAs, RNAs,...
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Cancer overdiagnosis: a biological challenge and clinical dilemma
For cancer screening to be successful, it should primarily detect cancers with lethal potential or their precursors early, leading to therapy that...
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Pathologic Classification and Biological Behavior of Pancreatic Neoplasia
Pancreatic neoplasms are classified according to the normal cells they recapitulate. These neoplasms’ clinicopathologic and biologic characteristics...
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Management of Cystic Neoplasms of the Pancreas Including IPMNs
The management of cystic pancreatic lesions fundamentally depends on knowing the cyst type and the risk or presence of malignancy. Only serous cystic...
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The microbiome, genetics, and gastrointestinal neoplasms: the evolving field of molecular pathological epidemiology to analyze the tumor–immune–microbiome interaction
Metagenomic studies using next-generation sequencing technologies have revealed rich human intestinal microbiome, which likely influence host...
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Reduced αGlcNAc glycosylation on gastric gland mucin is a biomarker of malignant potential for gastric cancer, Barrett’s adenocarcinoma, and pancreatic cancer
Gastric gland mucin secreted from pyloric gland cells, mucous neck cells, and cardiac gland cells of the gastric mucosa harbors unique O -glycans...
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The involvement of exosomes in the diagnosis and treatment of pancreatic cancer
At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that...
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Pancreatic adenocarcinoma: molecular drivers and the role of targeted therapy
Prognosis from pancreatic ductal adenocarcinoma (PDAC) continues to be poor despite the many efforts channeled to improve its management. Although...
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Transportome Malfunctions and the Hallmarks of Pancreatic Cancer
Ion channels and transporters (ICT) play important roles in almost all basic cellular processes. During last decades, abundant evidences have been...
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Altered glycosylation associated with dedifferentiation of hepatocellular carcinoma: a lectin microarray-based study
BackgroundAltered glycosylation associated with hepatocellular carcinoma (HCC) is well documented. However, few reports have investigated the...
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MicroRNAs in Pancreatic Cancer: biomarkers, prognostic, and therapeutic modulators
AbstractA severe lack of early diagnosis coupled with resistance to most available therapeutic options renders pancreatic cancer as a major clinical...
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Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs
Cancers are regarded as one of the main causes of death and result in high health burden worldwide. The management of cancer include chemotherapy,...
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Malignant Tissue Optical Properties
Modern optical biomedical technologies require a comprehensive knowledge of the optical properties of both healthy and tumor tissues in a wide range...
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Exact association test for small size sequencing data
BackgroundRecent statistical methods for next generation sequencing (NGS) data have been successfully applied to identifying rare genetic variants...
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The potential roles of exosomes in pancreatic cancer initiation and metastasis
Pancreatic cancer (PaCa) is an insidious and highly metastatic malignancy, with a 5-year survival rate of less than 5%. So far, the pathogenesis and...
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Mutations in key driver genes of pancreatic cancer: molecularly targeted therapies and other clinical implications
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a minimal difference between its incidence rate and mortality rate....
