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Polypharmacology in Drug Design and Discovery—Basis for Rational Design of Multitarget Drugs
Chapter 3 through Chap. 11 introduces the current status of clinical...
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Monoclonal Antibodies: Past, Present and Future
Monoclonal antibodies (mAbs) are immunoglobulins designed to target a specific epitope on an antigen. Immunoglobulins of identical amino-acid...
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Cancer Therapy
This chapter comprehensively and systematically reviews the different modalities of anti-cancer therapies. Therapeutic options are classified into...
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Monoclonal Antibodies in Cancer
The development of hybridoma technology by Kohler and Milstein 1975 was a milestone in the development of monoclonal antibody technology. It was...
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Thermal/Electrical Injuries
The skin is the primary barrier to the external insults an organism may encounter. It is a resilient and durable structure with many defense...
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Neuroprotective Agents
A pharmacological classification of various neuroprotective agents is shown in Table 2.1. Approximately 80 categories are listed and include examples...
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Implantable neurotechnologies: electrical stimulation and applications
Neural stimulation using injected electrical charge is widely used both in functional therapies and as an experimental tool for neuroscience...
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Biocompatibility Testing: The Biologic Tests
Most biocompatibility testing requirements are drawn from a common set of designs—from those guidelines called out by the ISO-10993-1 table. All...
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Obesity and Endometrial Cancer: Mouse Models for Preclinical Prevention Studies
Endometrial cancer risk is more strongly associated with obesity than any other cancer type and it is estimated that well over half of endometrial...
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Prospects of Natural Polymeric Scaffolds in Peripheral Nerve Tissue-Regeneration
Tissue-engineering is emerging field and can be considered as a novel therapeutic intervention in nerve tissue-regeneration. The various pitfalls...
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Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system
It is widely recognized that myelination of axons greatly enhances the speed of signal transmission. An exciting new finding is the dynamic...
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EpCAM-Independent Enrichment and Detection of Viable Circulating Tumor Cells Using the EPISPOT Assay
Identification and characterization of circulating tumor cells (CTCs) in peripheral blood can provide information on the direction and the efficacy...
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Correction of neurogenesis in the adult brain: Selection of therapeutic targets
Endogenous neurogenesis results in the formation of new neural structures that are prerequisites for numerous functions of the adult brain....
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Current Therapies and Future Directions in Treatment of Glioblastoma
The current standard of care for initial treatment of adults with newly diagnosed glioblastoma (GBM) constitutes maximal safe resection followed by...
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Nanointerventions for Gene Therapy
Selective silencing of an over-expressed gene or constitutively expressing an under-expressed gene represents an effective strategy to treat diseases...
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Neuroprotection in Miscellaneous Neurological Disorders
Several neurological disorders that are not covered in the preceding chapters result in damage to the brain requiring neuroprotection. In addition to...