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Why Does the Precautionary Principle Suffice for Blood Regulation?
Traditional approaches to blood regulation emphasise the precautionary principle and pursue zero-risk for viral transmission; these traditional...
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Ibuprofen, other NSAIDs and COVID-19: a narrative review
At the start of the coronavirus disease 2019 (COVID-19) pandemic (March 2020), there was speculation that non-steroidal anti-inflammatory drugs...
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Medication-related adverse events in health care—what have we learned? A narrative overview of the current knowledge
PurposeAlthough medication-related adverse events (MRAEs) in health care are vastly studied, high heterogeneity in study results complicates the...
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The Process of Drug Development from Natural Sources
The history of drug discovery and development is deeply knotted with human civilization. Early humans, driven by curiosity and the need for survival,...
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Evidence of the Impact of Interventions to Decrease Healthcare-Associated Infections
Healthcare-associated infections (HAIs) also called nosocomial infections are infections acquired within a healthcare facility. HAIs are of patient...
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Journey from an Enabler to a Strategic Leader: Integration of the Medical Affairs Function in ESG Initiatives and Values
Like most private enterprises, the pharmaceutical industry has deeply rooted environmental, social, and governance (ESG) matters that challenge its...
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Drug Donation Programmes in the Control and Elimination of NTDs
This chapter reviews the history and evolution of the medicine donation model that has been the mainstay of neglected tropical disease (NTD) control...
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11C-methionine in the diagnostics and management of glioblastoma patients with rapid early progression: nonrandomized, open label, prospective clinical trial (GlioMET)
BackgroundGlioblastoma (GBM) is the most common and aggressive primary brain cancer. The treatment of GBM consists of a combination of surgery and...
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Introduction to Pharmacoepidemiology and Its Application in Clinical Research
Pharmacoepidemiology, a sub-specialty of epidemiology involves the study of the use and effects (beneficial and safety) of drugs on large numbers of...
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Hospital Pharmacy Services: Ward Pharmacy, Compounding of Prescription, Extempore Preparation, Nuclear Medicine, Narcotic Drug Storage and Dispensing
Hospital pharmacy services came into prominence due to necessity of big multi-bedded hospital with super specialty operations. The teaching hospital,...
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Recurring Fatigue After Biologic Administration: Patient-Reported Data from the Dutch Biologic Monitor
BackgroundFatigue is a common problem in immune-mediated inflammatory disease (IMID) patients, significantly impacting their quality of life.
...
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Nutritional Supplements and Herbal Medicines
Nutritional supplements are foods meant to be enriched in vitamins, minerals or amino acids. They can be unpurified plant extracts, where several...
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Narcotic-Sparing Approaches and the Shift Toward Paracetamol in Neonatal Intensive Care
Effective analgesia in neonates is relevant not only because of ethical aspects or empathy, but it is a crucial and integral part of medical and...
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Proton pump inhibitors associated with an increased risk of mortality in elderly: a systematic review and meta-analysis
PurposeThe increased use of proton pump inhibitors (PPIs) in the elderly has raised concerns about potential severe adverse effects. Our systematic...
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Traditional Medical System (TMS) for Sustainable Healthcare in India
Traditional medicine has a long history. The World Health Organization (WHO) recognizes that traditional medicine (TM) is a vital part of the global...
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Defining the next generation of severe malaria treatment: a target product profile
BackgroundSevere malaria is a life-threatening infection, particularly affecting children under the age of 5 years in Africa. Current treatment with...
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The Emergency Use Authorization of Pharmaceuticals: History and Utility During the COVID-19 Pandemic
The Emergency Use Authorization (EUA) originated in 2004 because of the need for emergency medical countermeasures (MCMs) against potential...
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Structured content and data management—enhancing acceleration in drug development through efficiency in data exchange
Innovation in pharmaceutical therapeutics is critical for the treatment of serious diseases with unmet medical need. To accelerate the approval of...
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Vaccination and Multiple Sclerosis – Current Situation
Active immunization of patients with autoimmune diseases is a current challenge. Vaccination of patients with multiple sclerosis (MS) has been shown...