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Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro
Asthma is a chronic inflammatory disease characterized by airway remodeling and lung inflammation. Collagen triple helix repeat containing 1...
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Neuroprotective Effects of Resveratrol in In vivo and In vitro Experimental Models of Parkinson’s Disease: a Systematic Review
Parkinson’s disease (PD) is currently the second most common neurodegenerative disease, being characterized by motor and non-motor symptoms. The...
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Validating In Silico and In Vitro Patient-Specific Structural and Flow Models with Transcatheter Bicuspid Aortic Valve Replacement Procedure
IntroductionBicuspid aortic valve (BAV) is the most common congenital cardiac malformation, which had been treated off-label by transcatheter aortic...
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In vitro dissolution testing models of ocular implants for posterior segment drug delivery
The delivery of drugs to the posterior segment of the eye remains a tremendously difficult task. Prolonged treatment in conventional intravitreal...
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In Vitro and Ex Vivo Hair Follicle Models to Explore Therapeutic Options for Hair Regeneration
Introduction: Hair follicle regeneration and control of growth cycling is a small but growing field of study. Here we considered some of the more...
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Quantifying protrusions as tumor-specific biophysical predictors of cancer invasion in in vitro tumor micro-spheroid models
An important hallmark in cancer research is the discovery of suitable features capable to reliably predict tumor invasiveness, and consequently,...
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Characterization of Correction Factors to Enable Assessment of Clinical Risk from In Vitro CYP3A4 Induction Data and Basic Drug-Drug Interaction Models
Background and ObjectiveInduction of drug-metabolizing enzymes can lead to drug-drug interactions (DDIs); therefore, early assessment is often...
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Anti-rheumatic property and physiological safety of KMU-11342 in in vitro and in vivo models
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder characterized by joint destruction due to synovial hypertrophy and the...
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Development and functional testing of a novel in vitro delayed scratch closure assay
As the development of chronic wound therapeutics continues to expand, the demand for advanced assay systems mimicking the inflammatory wound...
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Functional biomaterials for biomimetic 3D in vitro tumor microenvironment modeling
The translational potential of promising anticancer medications and treatments may be enhanced by the creation of 3D in vitro models that can...
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Ascorbate: antioxidant and biochemical activities and their importance for in vitro models
Ascorbate has many biological activities that involve fundamental cellular functions such as gene expression, differentiation, and redox homeostasis....
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Alternative Animal Models in Cancer Research
Cancer, a broad word encompassing a range of diseases characterized by the excessive division of abnormal cells, has emerged as a major public health...
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In Vivo, Ex Vivo, and In Vitro Model Systems for Liver Cancer Research
Cancer claims the lives of millions of people worldwide. Liver cancer represents one such form of cancer that has a high incidence with a poor...
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In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition
Drug development for the central nervous system (CNS) is a complex endeavour with low success rates, as the structural complexity of the brain and...
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Modeling Intestinal Carcinogenesis Using In Vitro Organoid Cultures
Mouse models of intestinal carcinogenesis are very powerful tools for studying the impact of specific mutations on tumor initiation and progression....
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Assessment of biosafety and toxicity of hydrophilic gel for implantation in experimental in vitro and in vivo models
BackgroundThe assessment of biosafety of pharmacologically active substances is crucial for determining the feasibility of their medical use. There...
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In Vitro Assessment of Transporter Mediated Perpetrator DDIs for Several Hepatitis C Virus Direct-Acting Antiviral Drugs and Prediction of DDIs with Statins Using Static Models
Inhibitory effects of asunaprevir, daclatasvir, grazoprevir, paritaprevir, simeprevir, and voxilaprevir, direct-acting antiviral (DAA) drugs for the...
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Temperature Field in Bone During Robotic Dental Implant Drilling: Theoretical Models and In Vitro Experiments
PurposeBased on the clinical requirements of temperature control in dental implant surgery, this study aims to establish a theoretical model of the...
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Genistein protects against ultraviolet B–induced wrinkling and photoinflammation in in vitro and in vivo models
BackgroundChronic exposure to ultraviolet (UV) rays causes severe skin damage by inducing oxidative stress and inflammation. Identifying a safe and...
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Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro
Cyanobacterial harmful blooms (CyanoHABs) pose a global ecological problem, and their lipopolysaccharides (LPS) are among the bioactive compounds...
