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A highly immunogenic vaccine platform against encapsulated pathogens using chimeric probiotic Escherichia coli membrane vesicles
Vaccines against infectious diseases should elicit potent and long-lasting immunity, ideally even in those with age-related decline in immune...
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Antigenic and immunogenic properties of recombinant proteins consisting of two immunodominant African swine fever virus proteins fused with bacterial lipoprotein OprI
BackgroundAfrican swine fever (ASF) is a highly fatal swine disease, which threatens the global pig industry. There is no commercially available...
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The bovine dialysable leukocyte extract IMMUNEPOTENT CRP induces immunogenic cell death in breast cancer cells leading to long-term antitumour memory
BackgroundCancer recurrence is a serious problem in breast cancer (BC) patients, and immunogenic cell death (ICD) has been proposed as a strategy to...
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The potential utility of hybrid photo-crosslinked hydrogels with non-immunogenic component for cartilage repair
Finding a suitable biomaterial for scaffolding in cartilage tissue engineering has proved to be far from trivial. Nonetheless, it is clear that...
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Identification of a Cyclospora cayetanensis Oocyst Antigens and Their Validity in the Detection of Immunogenic Patterns of Cyclosporiasis Patients
IntroductionThe diagnosis of cyclosporiasis is currently based on the microscopic detection of oocysts, which may provide invalid results. The...
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IL-33 and IL-33-derived DC-based tumor immunotherapy
Interleukin-33 (IL-33), a member of the IL-1 family, is a cytokine released in response to tissue damage and is recognized as an alarmin. The...
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The identification of effective tumor-suppressing neoantigens using a tumor-reactive TIL TCR-pMHC ternary complex
Neoantigens are ideal targets for cancer immunotherapy because they are expressed de novo in tumor tissue but not in healthy tissue and are therefore...
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Intranasal powder live attenuated influenza vaccine is thermostable, immunogenic, and protective against homologous challenge in ferrets
Influenza viruses cause annual seasonal epidemics and sporadic pandemics; vaccination is the most effective countermeasure. Intranasal live...
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Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy
Current cancer immunotherapy has limited response rates in a large variety of solid tumors partly due to the low immunogenicity of the tumor cells...
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Oxaliplatin induces immunogenic cell death in hepatocellular carcinoma cells and synergizes with immune checkpoint blockade therapy
BackgroundHepatocellular carcinoma (HCC) is one of the most common and devastating malignancies. Oxaliplatin, a platinum-based chemotherapeutic...
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Mitoxantrone triggers immunogenic prostate cancer cell death via p53-dependent PERK expression
BackgroundMitoxantrone (MTX) is a synthetic compound used as a second line chemotherapeutic drug for prostate cancer. It has been reported to trigger...
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Actin-depolymerizing factor from Eimeria tenella promotes immunogenic function of chicken dendritic cells
Dendritic cells play a crucial role in inducing antigen-specific immunity to pathogens. During host-parasite interaction, host immune response to the...
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ALICE: a randomized placebo-controlled phase II study evaluating atezolizumab combined with immunogenic chemotherapy in patients with metastatic triple-negative breast cancer
BackgroundImmunotherapy with checkpoint inhibitors (CI) represents an important novel development in cancer treatment. Metastatic triple-negative...
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Identification of a high-risk immunogenic prostate cancer patient subset as candidates for T-cell engager immunotherapy and the introduction of a novel albumin-fused anti-CD3 × anti-PSMA bispecific design
BackgroundCancer immunotherapies such as bispecific T-cell engagers have seen limited adoption in prostate cancer (PC), possibly due to differing...
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Methods to Detect Immunogenic Cell Death In Vivo
In response to selected stressors, cancer cells can undergo a form of regulated cell death that—in immunocompetent syngeneic hosts—is capable of...
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Production of immunogenic recombinant L1 protein of bovine papillomavirus type 9 causing teat papillomatosis
Bovine papillomavirus type 9 (BPV9) is a causative agent of severe teat papillomatosis. Considering the lack of efficient BPV culture methods,...
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Immunoinformatic Risk Assessment of Host Cell Proteins During Process Development for Biologic Therapeutics
The identification and removal of host cell proteins (HCPs) from biologic products is a critical step in drug development. Despite recent...
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Damage-associated molecular patterns (DAMPs) related to immunogenic cell death are differentially triggered by clinically relevant chemotherapeutics in lung adenocarcinoma cells
BackgroundChemotherapeutics can stimulate immune antitumor response by inducing immunogenic cell death (ICD), which is activated by Damage-Associated...
