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High production of IL-12 by human dendritic cells stimulated with combinations of pattern-recognition receptor agonists
The cytokine IL-12p70 is crucial for T helper 1 (Th1) polarization and the generation of type 1 immunity required to fight cancer and pathogens....
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Ester tethered artemisinin-isatin hybrids: design, synthesis and anti-leukemic activity evaluation
A series of novel artemisinin-isatin hybrids ( 7a-t ) linked via different lengths of esters were designed, synthesized and evaluated for their...
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Dominance and improved survivability of human γδT17 cell subset aggravates the immunopathogenesis of pemphigus vulgaris
Human γδ T cells are highly enriched in epithelial cell-dominated compartments like skin. Nonetheless, their function in the pathogenesis of...
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Establishment of a humanized mouse model of keloid diseases following the migration of patient immune cells to the lesion: Patient-derived keloid xenograft (PDKX) model
Keloid disorder is an abnormal fibroproliferative reaction that can occur on any area of skin, and it can impair the quality of life of affected...
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Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
BackgroundIt has become evident in the field of oncology that the outcome of medical treatment is influenced by the combined effect exerted on both...
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Comprehensive evaluation of the effects of long-term cryopreservation on peripheral blood mononuclear cells using flow cytometry
Human peripheral blood mononuclear cells (PBMCs) originate from hematopoietic stem cells in the bone marrow, which mainly includes lymphocytes (T...
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Improving the cytotoxic response of tumor-infiltrating lymphocytes towards advanced stage ovarian cancer with an oncolytic adenovirus expressing a human vIL-2 cytokine
While the presence of tumor-infiltrating lymphocytes (TILs) associates with improved survival prognosis in ovarian cancer (OvCa) patients, TIL...
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Effect of cryopreservation on DNA damage and DNA repair activity in human blood samples in the comet assay
The comet assay is a commonly used method to determine DNA damage and repair activity in many types of samples. In recent years, the use of the comet...
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Identification of cross reactive T cell responses in adenovirus based COVID 19 vaccines
Vaccination has proven to be a valuable tool to combat SARS-CoV-2. However, reports of rare adverse reactions such as thrombosis/thrombocytopenia...
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Alterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy
BackgroundThe phase II neo-adjuvant clinical trial ICORG10-05 (NCT01485926) compared chemotherapy in combination with trastuzumab, lapatinib or both...
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A human antibody epitope map of the malaria vaccine antigen Pfs25
Pfs25 is a leading antigen for a malaria transmission-blocking vaccine and shows moderate transmission-blocking activity and induction of rapidly...
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CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma
BackgroundGlioblastoma (GBM) is the most common malignant brain tumor and has “immunologically cold” features. Changing GBM to an “immunologically...
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Effects of helminths on the human immune response and the microbiome
Helminths have evolved sophisticated immune regulating mechanisms to prevent rejection by their mammalian host. Our understanding of how the human...
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Inherited IRAK-4 Deficiency in Acute Human Herpesvirus-6 Encephalitis
Human herpesvirus-6 (HHV-6) infection can rarely cause life-threatening conditions, such as encephalitis, in otherwise healthy children, with unclear...
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Organotin and organochlorine toxicants activate key translational regulatory proteins in human immune cells
Environmental contaminant exposures occur due to the widespread use of synthetic chemicals. Tributyltin (TBT), dibutyltin (DBT), and...
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Interference of the Human Genome with Nutrients
In this chapter, we will discuss the complex relation between our environment, diet and genome. Genes influence our response to diet, while...
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Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73)
Plasmacytoid dendritic cells (pDCs) are a specialized DC subset mainly associated with sensing viral pathogens and high-type I interferon (IFN-I)...
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TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells
BackgroundHuman endosomal Toll-like receptors TLR7 and TLR8 recognize self and non-self RNA ligands, and are important mediators of innate immunity...
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Immunogenicity of MultiTEP platform technology-based Tau vaccine in non-human primates
Pathological forms of Tau protein are directly associated with neurodegeneration and correlate with Alzheimer’s Disease (AD) symptoms, progression,...
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Induction of Exaggerated Cytokine Production in Human Peripheral Blood Mononuclear Cells by a Recombinant SARS-CoV-2 Spike Glycoprotein S1 and Its Inhibition by Dexamethasone
An understanding of the pathological inflammatory mechanisms involved in SARS-CoV-2 virus infection is necessary in order to discover new molecular...
