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Harnessing adenovirus in cancer immunotherapy: evoking cellular immunity and targeting delivery in cell-specific manner
Recombinant adenovirus (rAd) regimens, including replication-competent oncolytic adenovirus (OAV) and replication-deficient adenovirus, have been...
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Application of Human Adenovirus Genoty** by Phylogenetic Analysis in an Outbreak to Identify Nosocomial Infection
Nosocomial infections are common in pediatric patients and can be fatal in infants and immunocompromised patients. In September 2018, a high positive...
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Adenoviral vector vaccine platforms in the SARS-CoV-2 pandemic
Adenoviral vectors have been explored as vaccine agents for a range of infectious diseases, and their ability to induce a potent and balanced immune...
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Isolation and whole-genome sequencing of a novel aviadenovirus from owls in Japan
Adenoviruses have been reported to infect a variety of birds. Here, we isolated a novel adenovirus from the liver of a dead owl chick (Bengal eagle...
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Viral Cytotoxic T Lymphocytes (CTLs): From Bench to Bedside
It was first demonstrated almost three decades ago that adoptive transfer of viral-specific T cells could prevent or eradicate viral disease in...
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Optimising T cell (re)boosting strategies for adenoviral and modified vaccinia Ankara vaccine regimens in humans
Simian adenoviral and modified vaccinia Ankara (MVA) viral vectors used in heterologous prime-boost strategies are potent inducers of T cells against...
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Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective
AbstractDespite the development of novel pharmacological treatments, cardiovascular disease morbidity and mortality remain high indicating an unmet...
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The use of viral vectors in vaccine development
Vaccines represent the single most cost-efficient and equitable way to combat and eradicate infectious diseases. While traditional licensed vaccines...
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Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial
Immune-mediated anti-tumoral responses, elicited by oncolytic viruses and augmented with checkpoint inhibition, may be an effective treatment...
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Human adenovirus among hospitalized children with respiratory tract infections in Bei**g, China, 2017–2018
BackgroundHuman adenoviruses (HAdVs) cause a wide range of diseases. However, the genotype diversity and epidemiological information relating to...
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Viral loads in nasopharyngeal aspirates and tracheal aspirates among children hospitalized with invasive ventilation for human adenovirus pneumonia
PurposeTo evaluate viral loads in children with human adenovirus (HAdV) pneumonia at different stages of disease and compare the viral load between...
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Diversity of enteric and non-enteric human adenovirus strains in Brazil, 2006-2011
During 2006-2011, 5035 fecal samples were tested by PCR for human adenovirus (HAdV) and sequenced. HAdV was detected in 198 cases (3.9%), with the...
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Intravesical Infusion of Oncolytic Virus CG0070 in the Treatment of Bladder Cancer
CG0070 is a conditionally replicating oncolytic adenovirus that preferentially replicates within and kills Rb-defective cancer cells. It has been...
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Immunization against Zika by entrap** live virus in a subcutaneous self-adjuvanting hydrogel
The threat of new viral outbreaks has heightened the need for ready-to-use vaccines that are safe and effective. Here we show that a subcutaneous...
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Insidious Insights: Implications of viral vector engineering for pathogen enhancement
Optimizing viral vectors and their properties will be important for improving the effectiveness and safety of clinical gene therapy. However, such...
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Virological Characterization of Roof-Harvested Rainwater of Densely Urbanized Low-Income Region
Roof-harvested rainwater (RHRW) is considered relatively clean water, even though the possible presence of pathogens in the water may pose human...
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The effects of β1 and β1+2 adrenergic receptor blockade on the exercise-induced mobilization and ex vivo expansion of virus-specific T cells: implications for cellular therapy and the anti-viral immune effects of exercise
The adoptive transfer of donor-derived virus-specific T cells (VSTs) is an effective treatment for infections following allogeneic hematopoietic cell...
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Desmoglein 2 (DSG2) Is A Receptor of Human Adenovirus Type 55 Causing Adult Severe Community-Acquired Pneumonia
Human adenovirus type 55 (HAdV-B55) is a re-emergent acute respiratory disease pathogen that causes adult community-acquired pneumonia (CAP)....
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Progress in mass spectrometry approaches to profiling protein–protein interactions in the studies of the innate immune system
Understanding protein–protein interactions (PPIs) is pivotal for deciphering the intricacies of biological processes. Dysregulation of PPIs underlies...
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Characterization of the First Genome of Porcine mastadenovirus B (HNU1 Strain) and Implications on Its Lymphoid and Special Origin
Porcine adenoviruses (PAdVs) are classified into three species, PAdV-A, PAdV-B, and PAdV-C. The genomes of PAdV-A and PAdV-C have been well...
