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High rate of extended-spectrum beta-lactamase-producing gram-negative infections and associated mortality in Ethiopia: a systematic review and meta-analysis
BackgroundExtended-spectrum beta-lactamase (ESBL)-producing Gram-negative bacteria have become a serious threat to global health. Their rapid spread...
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Detection of carbapenemases blaOXA48-blaKPC-blaNDM-blaVIM and extended-spectrum-β-lactamase blaOXA1-blaSHV-blaTEM genes in Gram-negative bacterial isolates from ICU burns patients
Background and objectivesBurn patients are highly susceptible to invasion by multidrug-resistant Gram-negative bacteria (MDR-GNB) through post-burn...
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Emergence of multidrug-resistant non-fermentative gram negative bacterial infection in hospitalized patients in a tertiary care center of Nepal
ObjectiveThis study was designed for the characterization and establishment of antibiotic susceptibility profiles of non-fermentative gram negative...
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Rapid detection of carbapenemase-producing organisms directly from blood cultures positive for Gram-negative bacilli
IntroductionThe rapid detection of carbapenemase-producing organisms (CPOs) directly from blood cultures (BCs) positive for Gram-negative bacilli...
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Pentamidine sensitizes FDA-approved non-antibiotics for the inhibition of multidrug-resistant Gram-negative pathogens
Pentamidine sensitizes FDA-approved antibiotics to combat Gram-negative pathogens. We screened 1374 FDA-approved non-antibiotics for their ability to...
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Extended-spectrum β-lactamase blaCTX-M-1 group in gram-negative bacteria colonizing patients admitted at Mazimbu hospital and Morogoro Regional hospital in Morogoro, Tanzania
ObjectiveThe objective of this study was to determine the proportion of extended spectrum β-lactamase producing gram-negative bacteria (ESBL-GNB)...
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Carriage of ESBL-producing Gram-negative bacteria by flies captured in a hospital and its suburban surroundings in Ethiopia
BackgroundLocal data from the Asella Teaching and Referral Hospital in the town of Asella, Ethiopia reveal a high prevalence of extended-spectrum...
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Epidemiology and Prevalence of Beta-Lactamases and Recent Resistance Pattern in Gram-Negative Bacteria from Environmental Reservoirs
Antibiotic resistance has largely been studied in the context of clinical settings, but subsequently with time it is being realized that bacteria...
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Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria
The complement system is a vital component of the innate immune system, though its role in bacteremia is poorly understood. We present complement...
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The role of hospital environment in transmissions of multidrug-resistant gram-negative organisms
Infections by multidrug-resistant (MDR) Gram-negative organisms (GN) are associated with a high mortality rate and present an increasing challenge to...
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Performances of automated digital imaging of Gram-stained slides with on-screen reading against manual microscopy
The objective of this study was to evaluate the performances of the automated digital imaging of Gram-stained slides against manual microscopy. Four...
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Two years study of prevalence and antibiotic resistance pattern of Gram-negative bacteria isolated from surgical site infections in the North of Iran
ObjectiveThe present study aimed to investigate the frequency and antibiotic susceptibility pattern of Gram-negative bacteria (GNB) isolated from...
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A high prevalence of multi-drug resistant Gram-negative bacilli in a Nepali tertiary care hospital and associated widespread distribution of Extended-Spectrum Beta-Lactamase (ESBL) and carbapenemase-encoding genes
BackgroundMulti-drug resistance (MDR) and extensive-drug resistance (XDR) associated with extended-spectrum beta-lactamases (ESBLs) and...
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Efficacy of a coordinated strategy for containment of multidrug-resistant Gram-negative bacteria carriage in a Neonatal Intensive Care Unit in the context of an active surveillance program
BackgroundAntimicrobial resistance in neonatal intensive care unit (NICU) patients is a threat, due to the frequent use of antimicrobial treatment...
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Identification and antimicrobial susceptibility testing of Gram-positive and Gram-negative bacteria from positive blood cultures using the Accelerate Pheno™ system
Rapid identification and antimicrobial susceptibility testing remain a crucial step for early efficient therapy of bloodstream infections....
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Carbapenem Resistance in Gram-Negative Bacilli: Mechanisms and Challenges
The emergence of carbapenem resistance within the Gram-negative bacilli including Enterobacteriaceae, Pseudomonas spp., and non-fermenters like...
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Rapid identification and antimicrobial susceptibility testing of Gram-negative rod on positive blood cultures using MicroScan panels
Shortening the turnaround time of antimicrobial susceptibility testing (AST) of bacteria permits a significant reduction of patient morbidity,...
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The implementation of rapid microbial identification via MALDI-ToF reduces mortality in gram-negative but not gram-positive bacteremia
Our goals were to study the effect of rapid microbial identification (RMI) of positive blood culture on patient’s outcome and to identify specific...
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Molecular characterization of multidrug-resistant Gram-negative pathogens in three tertiary hospitals in Cairo, Egypt
High rates of antimicrobial resistance (AMR) among Gram-negative pathogens (GNP) have been reported in Egypt. Antimicrobial surveillance and...
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Applications of Photodynamic Therapy for the Eradication of ESKAPE Pathogens
Antimicrobial photodynamic therapy (aPDT) is one of the efficient and alternate therapeutic strategies to combat planktonic and biofilm cells of...