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Podoplanin mediates the renoprotective effect of berberine on diabetic kidney disease in mice
Hyperglycemia-caused podocyte injury plays a crucial role in the progress of diabetic kidney disease. Podoplanin, one of the podocyte-associated...
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LRG1: an emerging player in disease pathogenesis
The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a key player in pathogenic ocular neovascularization almost a...
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Molecular mechanisms determining severity in patients with Pierson syndrome
Null variants in LAMB2 cause Pierson syndrome (PS), a severe congenital nephrotic syndrome with ocular and neurological defects. Patients’ kidney...
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Hereditary Proteinuric Glomerular Disorders
A 26-year-old male first manifested asymptomatic proteinuria at age 16 years at a regular checkup. Because of persistent proteinuria, he was referred...
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TRP Channels in Renal Epithelia
Invariability of the internal milieu of the body is essential for normal physiology. Kidneys are imperative for systemic homeostasis and blood...
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Cell Apoptosis and Autophagy in Renal Fibrosis
Renal fibrosis is the final common pathway of all chronic kidney diseases progressing to end-stage renal diseases. Autophagy, a highly conserved...
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The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation
Epalrestat is an inhibitor of aldose reductase in the polyol pathway and is used for the management of diabetic neuropathy clinically. Our pilot...
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Porcine models for studying complications and organ crosstalk in diabetes mellitus
The worldwide prevalence of diabetes mellitus and obesity is rapidly increasing not only in adults but also in children and adolescents. Diabetes is...
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Inflammatory Mechanisms in Diabetic Kidney Disease
Up to half of all patients with diabetes will develop diabetic kidney disease (DKD), the leading cause of end-stage kidney disease worldwide. The...
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Role of sirtuin-1 in diabetic nephropathy
Diabetic nephropathy (DN) is a research priority for scientists around the world because of its high prevalence and poor prognosis. Although several...
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Histological Examination of the Diabetic Kidney
The increasing prevalence of diabetes worldwide has led to a concomitant rise in diabetic kidney disease (DKD) as a major cause of end-stage renal...
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Oxidative Stress and Renal Fibrosis: Mechanisms and Therapies
Oxidative stress results from the disruption of the redox system marked by a notable overproduction of reactive oxygen species. There are four major...
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A comprehensive analysis of NPHS1 gene mutations in patients with sporadic focal segmental glomerulosclerosis
BackgroundFocal segmental glomerulosclerosis (FSGS) is still one of the common causes of refractory nephrotic syndrome. Nephrin, encoded by...
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Initial experience from a renal genetics clinic demonstrates a distinct role in patient management
PurposeA Renal Genetics Clinic (RGC) was established to optimize diagnostic testing, facilitate genetic counseling, and direct clinical management.
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Three cases of multicentric carpotarsal osteolysis syndrome: a case series
BackgroundMulticentric carpotarsal osteolysis syndrome (MCTO) is characterized by progressive destruction and disappearance of the carpal and tarsal...
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Chrysin ameliorates podocyte injury and slit diaphragm protein loss via inhibition of the PERK-eIF2α-ATF-CHOP pathway in diabetic mice
Glomerular epithelial podocytes are highly specialized cells that play a crucial role in maintaining normal function of the glomerular filtration...
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Mitochondria and Renal Fibrosis
Mitochondria are important organelles in eukaryotic cells and perform a variety of biosynthetic and metabolic functions. Many human diseases are...
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Novel variants in COL4A4 and COL4A5 are rare causes of FSGS in two unrelated families
We report two female patients with focal segmental glomerulosclerosis and chronic kidney disease. The first patient was found to have a heterozygous,...
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Inflammatory Mediators and Renal Fibrosis
Renal inflammation is the initial, healthy response to renal injury. However, prolonged inflammation promotes the fibrosis process, which leads to...