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1. Retraction Note: K-ras-ERK1/2 down-regulates H2A.X^Y142ph through WSTF to promote the progress of gastric cancer

   This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12885-019-5750-x

   Chao Dong, **g Sun, ... Guoying Zhang in BMC Cancer

   Article Open access 07 September 2022

2. Ethanol Stimulation of Microglia Release Increases ERK1/2-Dependent Neuronal cPLA₂ Activity in Immature Cultured Cortical Preparations

   Ethanol consumption typically begins during adolescence and is associated with age-dependent responses and maladaptive neuronal consequences. Our...

   J. L. Santerre-Anderson, D. F. Werner in Neurochemical Research

   Article 09 April 2020
   

3. Cyclosporin A activates human hepatocellular carcinoma (HepG2 cells) proliferation: implication of EGFR-mediated ERK1/2 signaling pathway

   One of the most common causes of cancer mortality worldwide is hepatocellular carcinoma (HCC). Extracellular signal-regulated kinase (ERK1/2) pathway...

   Mohammed E. Abo-El Fetoh, Gouda K. Helal, ... El-Sayed Akool in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article 06 January 2020
   

4. CCR1 Activation Promotes Neuroinflammation Through CCR1/TPR1/ERK1/2 Signaling Pathway After Intracerebral Hemorrhage in Mice

   The activation of C-C chemokine receptor type 1 (CCR1) has been shown to be pro-inflammatory in several animal models of neurological diseases. The...

   Jun Yan, Gang Zuo, ... Ji** Tang in Neurotherapeutics

   Article 02 January 2020
   

5. Correction to: Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways

   Chengli Liu, Qi Tian, ... Mingchang Li in Molecular Neurobiology

   Article 23 November 2022

6. Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis

   Intracerebral hemorrhage (ICH) is a catastrophic stroke with high mortality, and the mechanism underlying ICH is largely unknown. Previous studies...

   Ning **ao, Tian-long Liu, ... **g-zhou Chen in Translational Stroke Research

   Article 22 April 2020
   

7. Features of Intracellular Signal Transduction in Neural Stem Cells under the Influence of Alkaloid Songorine, an Agonist of Fibroblast Growth Factor Receptors

   We performed a comparative in vitro study of the involvement of NF-κB, PI3K, cAMP, ERK1/2, p38, JAKs, STAT3, JNK, and p53-dependent intracellular...

   G. N. Zyuz’kov, E. A. Losev, ... V. V. Zhdanov in Bulletin of Experimental Biology and Medicine

   Article 01 March 2024

8. MSCs-Derived Exosomes Attenuate Acute Brain Injury and Inhibit Microglial Inflammation by Reversing CysLT2R-ERK1/2 Mediated Microglia M1 Polarization

   Inflammatory responses play a major role in the pathophysiology of cerebral ischemia. Mesenchymal stem cell-derived exosomes (MSC-exos) have...

   Yangmin Zhao, Yunxiao Gan, ... Dandan Liu in Neurochemical Research

   Article 28 February 2020
   

9. EGFL6 activates the ERK signaling to improve angiogenesis and osteogenesis of BMSCs in patients with steroid-induced osteonecrosis of the femoral head

   Recently, epidermal growth factor-like domain protein 6 ( EGFL6 ) was proposed as a candidate gene for coupling angiogenesis to osteogenesis during...

   Penghui Bu, Weipeng **e, ... Shouye Hu in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article 12 December 2023
   

10. LNK promotes the growth and metastasis of triple negative breast cancer via activating JAK/STAT3 and ERK1/2 pathway

    Background

    LNK adaptor protein is a crucial regulator of normal hematopoiesis, which down-regulates activated tyrosine kinases at the cell surface...

    Jianxin Lv, Wei Yu, ... Chenfei Wang in Cancer Cell International

    Article Open access 15 April 2020
    

11. Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing

    Inflammatory pain, sustained by a complex network of inflammatory mediators, is a severe and persistent illness affecting many of the general...

    Zhenglang Zhang, Tingting Wang, ... Hong Nie in Purinergic Signalling

    Article 20 November 2023
    

12. The Impact of Dipyridamole on Disease-Associated Microglia Phenotypic Transformation in White Matter Lesions Induced by Chronic Cerebral Hypoperfusion

    White matter lesions (WMLs) resulting from chronic cerebral hypoperfusion (CCH) are the leading cause of vascular dementia (VaD). This study aimed to...

    Wenchao Cheng, Yuhan Wang, ... Wen Huang in Neurochemical Research

    Article 15 December 2023
    

13. ERK1/2-HNF4α axis is involved in epigallocatechin-3-gallate inhibition of HBV replication

    Epigallocatechin gallate (EGCG), a major polyphenol in green tea, exhibits diverse biological activities. Previous studies show that EGCG could...

    Zi-yu Wang, Yu-qi Li, ... Bo Gao in Acta Pharmacologica Sinica

    Article 25 September 2019
    

14. Circ_0032821 acts as an oncogene in cell proliferation, metastasis and autophagy in human gastric cancer cells in vitro and in vivo through activating MEK1/ERK1/2 signaling pathway

    Background

    Circular RNA (circRNA) is increasingly attracting attention in gastric cancer (GC). Hsa_circ_0032821 (circ_0032821) has been declared to be...

    Yuanyuan Jiang, Yan Zhang, ... Huili Wu in Cancer Cell International

    Article Open access 06 March 2020
    

15. Inhibition of TMEM16A improves cisplatin-induced acute kidney injury via preventing DRP1-mediated mitochondrial fission

    Acute kidney injury (AKI) is associated with high morbidity and mortality. Our previous study has demonstrated that TMEM16A, a Ca ²⁺ -activated...

    **ao-long Li, Xue-wu Liu, ... Yan-hua Du in Acta Pharmacologica Sinica

    Article 04 July 2023
    

16. Long noncoding RNA NEAT1 is involved in the protective effect of Klotho on renal tubular epithelial cells in diabetic kidney disease through the ERK1/2 signaling pathway

    Klotho, an antiaging protein, has been shown to play a protective role in renal tubular epithelial-mesenchymal transition (EMT) during the...

    Yan-Lin Yang, Meng Xue, ... Yao-Ming Xue in Experimental & Molecular Medicine

    Article Open access 14 February 2020
    

17. Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration

    Background

    Extracellular matrix stiffness is emerging as a crucial mechanical cue that drives the progression of various diseases, such as cancer,...

    Wencan Ke, Bing** Wang, ... Cao Yang in Journal of Translational Medicine

    Article Open access 10 October 2023
    

18. CAFs-derived rho-associated kinase1 mediated EMT to promote laryngeal squamous cell carcinoma metastasis

    Background

    Cancer-associated fibroblasts (CAFs) play an essential role in tumorigenesis and development of cancers. Nevertheless, the specific...

    Liyun Yang, Shiqi Gong, ... An Hu in Cancer Cell International

    Article Open access 16 April 2023
    

19. Mechanism of Endogenous Peptide PDYBX1 and Precursor Protein YBX1 in Hirschsprung’s Disease

    Endogenous peptides, bioactive agents with a small molecular weight and outstanding absorbability, regulate various cellular processes and diseases....

    Qiaochu Sun, Zhengke Zhi, ... Weibing Tang in Neuroscience Bulletin

    Article 01 October 2023
    

20. Irisin exhibits neuroprotection by preventing mitochondrial damage in Parkinson’s disease

    Exercise has been proposed as an effective non-pharmacological management for Parkinson’s disease (PD) patients. Irisin, a recently identified...

    ** Zhang, Sutong Xu, ... Siguang Li in npj Parkinson's Disease

    Article Open access 31 January 2023