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Mitochondrial metabolism of the facultative parasite Chilodonella uncinata (Alveolata, Ciliophora)
BackgroundChilodonella uncinata is an aerobic ciliate capable of switching between being free-living and parasitic on fish fins and gills, causing...
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Effects of Chronic Hypertension on the Energy Metabolism of Cerebral Cortex Mitochondria in Normotensive and in Spontaneously Hypertensive Rats During Aging
In this study the subcellular modifications undergone by cerebral cortex mitochondrial metabolism in chronic hypertension during aging were...
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Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply
The medium-chain fatty acids octanoic acid (C8) and decanoic acid (C10) are gaining attention as beneficial brain fuels in several neurological...
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Reactive Oxygen Species–Induced Cancer Cell Death: A Therapeutic Approach
Reactive oxygen species (ROS) are molecules that contain oxygen, generated by metabolically active cells. Endogenous and exogenous factors play a...
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COVID-19 and the Assessment of Coenzyme Q10
Coenzyme Q10 (CoQ10) plays an essential electron carrier role in the mitochondrial electron transfer chain (ETC) as well as being a potent...
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Reactive Oxygen Species Induced Cancer Cell Death – A Therapeutic Approach
Reactive oxygen species (ROS) are molecules that contain oxygen, generated by metabolically active cells. Endogenous and exogenous factors play a...
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Mitochondrial Electron Transport Chain Complex Dysfunction in MeCP2 Knock-Down Astrocytes: Protective Effects of Quercetin Hydrate
Astrocytes play the central role in CNS metabolism to support neuronal functions. Mehyl-CpG-binding protein 2 (MeCP2) is the global transcription...
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Linking mitochondrial dynamics and fertility: promoting fertility by phoenixin through modulation of ovarian expression of GnRH receptor and mitochondrial dynamics proteins DRP-1 and Mfn-2
Obesity is linked to reproductive disorders. Novel neuropeptide phoenixin demonstrated many therapeutic actions. In this study, we aim to evaluate...
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Mechanisms of Dopamine Oxidation and Parkinson’s Disease
Dopamine’s ability to oxidize to aminochrome explains why this molecule may be a neurotoxic compound that induces toxicity in both cell lines and...
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Mechanisms of Dopamine Oxidation and Parkinson’s Disease
Dopamine’s ability to oxidize to aminochrome explains why this molecule may be a neurotoxic compound that induces toxicity in both cell lines and...
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Heat shock protein 27 deficiency promotes ferrous ion absorption and enhances acyl-Coenzyme A synthetase long-chain family member 4 stability to promote glioblastoma cell ferroptosis
BackgroundGlioblastoma is one of the malignant tumors of the central nervous system with high lethality, high disability and low survival rate....
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Short-Chain Fatty Acids as Therapeutic Agents in Colon Malignancies
Colon cancer has taken a large number of lives worldwide and stands among the few topmost killer malignancies. Although several approaches to combat...
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Inhibition of mitochondrial respiration by general anesthetic drugs
General anesthetic drugs have been associated with various unwanted effects including an interference with mitochondrial function. We had previously...
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Ketone Body Rescued Seizure Behavior of LRP1 Deficiency in Drosophila by Modulating Glutamate Transport
LRP1 , the low-density lipoprotein receptor 1, would be a novel candidate gene of epilepsy according to our bioinformatic results and the animal...
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Altered acylcarnitine metabolism and inflexible mitochondrial fuel utilization characterize the loss of neonatal myocardial regeneration capacity
Myocardial regeneration capacity declines during the first week after birth, and this decline is linked to adaptation to oxidative metabolism....
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Antagonism of the Muscarinic Acetylcholine Type 1 Receptor Enhances Mitochondrial Membrane Potential and Expression of Respiratory Chain Components via AMPK in Human Neuroblastoma SH-SY5Y Cells and Primary Neurons
Impairments in mitochondrial physiology play a role in the progression of multiple neurodegenerative conditions, including peripheral neuropathy in...
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An essential gene signature of breast cancer metastasis reveals targetable pathways
BackgroundThe differential gene expression profile of metastatic versus primary breast tumors represents an avenue for discovering new or...
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Protein Structure and Modification of Aquaporins
Aquaporins (AQPs) allow water molecules and other small, neutral solutes to quickly pass through membrane. The protein structures of AQPs solved by...
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Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress
BackgroundMetabolic adaptations can allow cancer cells to survive DNA-damaging chemotherapy. This unmet clinical challenge is a potential...
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Arsenic: An Environmental Toxicant-Induced Oxidative Stress and Carcinogenesis
Inorganic arsenic is considered as an environmental toxicant and Group I carcinogen. Globally millions of people are suffering from adverse health...