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Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer
BackgroundWith the development and popularization of low-dose chest CT technology, the diagnosis and survival rates of patients with early lung...
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Antineoplastic Effects of Curcumin Against Colorectal Cancer: Application and Mechanisms
Curcumin is one of the major bioactive metabolites of turmeric, a spice component common in southeast Asia. Curcumin is known for its...
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Inherited BRCA1 and RNF43 pathogenic variants in a familial colorectal cancer type X family
Genetic susceptibility to familial colorectal cancer (CRC), including for individuals classified as Familial Colorectal Cancer Type X (FCCTX),...
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Optimized screening of DNA methylation sites combined with gene expression analysis to identify diagnostic markers of colorectal cancer
BackgroundThe prognosis of patients with colorectal cancer is related to early detection. However, commonly used screening markers lack sensitivity...
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Randomised phase II trial of trifluridine/tipiracil (FTD/TPI) plus ramucirumab (RAM) versus trifluridine/tipiracil for previously treated patients with advanced gastric or esophagogastric junction adenocarcinoma (RETRIEVE study, WJOG15822G)
BackgroundTrifluridine/tipiracil (FTD/TPI) prolongs survival in the third- or later-line treatment for advanced gastric cancer (GC), esophagogastric...
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A Japanese case of ovarian mucinous adenocarcinoma with germline double variants of MSH2 and BRCA2
Germline double heterozygosity (GDH) is rarely reported in cases of inherited cancer syndromes, and GDH of a mismatch repair gene and BRCA has never...
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New insights into macrophage polarization and its prognostic role in patients with colorectal cancer liver metastasis
BackgroundAs liver metastasis is the most common cause of mortality in patients with colorectal cancer, studying colorectal cancer liver metastasis...
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The depth of perineural invasion is an independent prognostic factor for stage II colorectal cancer
BackgroundPerineural invasion (PNI) is the invasion of nerves by cancer cells and is associated with poor survival in stage II colorectal cancer....
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MALAT1-related signaling pathways in colorectal cancer
Colorectal cancer (CRC) is one of the most lethal and prevalent solid malignancies worldwide. There is a great need of accelerating the development...
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Novel biomarker SARIFA in colorectal cancer: highly prognostic, not genetically driven and histologic indicator of a distinct tumor biology
SARIFA (Stroma AReactive Invasion Front Areas) has recently emerged as a promising histopathological biomarker for colon and gastric cancer. To...
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Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening
BackgroundHereditary factors, including single genetic variants and family history, can be used for targeting colorectal cancer (CRC) screening, but...
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METTL3 recruiting M2-type immunosuppressed macrophages by targeting m6A-SNAIL-CXCL2 axis to promote colorectal cancer pulmonary metastasis
BackgroundThe regulatory role of N6-methyladenosine (m6A) modification in the onset and progression of cancer has garnered increasing attention in...
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Aspirin increases chemosensitivity of colorectal cancer cells and inhibits the expression of toll-like receptor 4
BackgroundChemotherapy resistance is an important bottleneck affecting the efficacy of chemotherapy in colon cancer. Therefore, improving the...
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Plasma cell signatures predict prognosis and treatment efficacy for lung adenocarcinoma
PurposeThis study aims to identify key genes regulating tumor infiltrating plasma cells (PC) and provide new insights for innovative immunotherapy....
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Establishment of disulfidptosis-related LncRNA signature as biomarkers in colon adenocarcinoma
PurposeMetabolic reprogramming is a hallmark of cancer and plays a key role in precision oncology treatment. Long non-coding RNAs (lncRNAs) regulate...
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Interaction of lncRNAs with mTOR in colorectal cancer: a systematic review
Colorectal cancer (CRC) is the third most widespread cancer and the fourth leading lethal disease among different societies. It is thought that CRC...
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TGFβ signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer
RationaleColorectal Cancer (CRC) represents the third most common type of cancer in Germany and the second most common cancer-related cause of death...
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Associations of IFT20 and GM130 protein expressions with clinicopathological features and survival of patients with lung adenocarcinoma
BackgroundLung cancer is the leading cause of malignancy-related mortality and lung adenocarcinoma accounts for about 40% of lung malignancies. The...
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STK11 loss leads to YAP1-mediated transcriptional activation in human KRAS-driven lung adenocarcinoma cell lines
Serine Threonine Kinase 11 (STK11) loss of function (LoF) correlates with anti-PD-1 therapy resistance in patients with KRAS-driven lung...
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Detection of (pre)cancerous colorectal lesions in Lynch syndrome patients by microsatellite instability liquid biopsy
Lynch syndrome (LS) is an inherited condition characterized by an increased risk of develo** cancer, in particular colorectal cancer (CRC)....
