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Fluorescence Variation in Selective Sensing of Hg2+and Cu2+ Ions By Coumarin-xanthene Fused Optical Probe
The fluorescent moieties coumarin and xanthene (R6GCP) combined in a single molecule was designed and synthesized. The colorimetric and fluorescent...
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Determination of Fraction Unbound and Unbound Partition Coefficient to Estimate Intracellular Free Drug Concentration
Intracellular free drug concentrations are critical to develop pharmacokinetic and pharmacodynamic relationships, estimate therapeutic indices, and...
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Genetic regulation and variation of expression of miRNA and mRNA transcripts in fetal muscle tissue in the context of sex, dam and variable fetal weight
BackgroundImpaired skeletal muscle growth in utero can result in reduced birth weight and pathogenesis of intrauterine growth restriction. Fetal and...
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Physical geography, isolation by distance and environmental variables shape genomic variation of wild barley (Hordeum vulgare L. ssp. spontaneum) in the Southern Levant
Determining the extent of genetic variation that reflects local adaptation in crop-wild relatives is of interest for the purpose of identifying...
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SLC11A1 genetic variation and low expression may cause immune response impairment in TB patients
Tuberculosis (TB) is caused by Mycobacterium tuberculosis . Host genetic factors are important for the detection of TB susceptibility. SLC11A1 is...
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Effects of average reward rate on vigor as a function of individual variation in striatal dopamine
RationaleWe constantly need to decide not only which actions to perform, but also how vigorously to perform them. In agreement with an earlier...
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BOLD turnover in task-free state: variation among brain areas and effects of age and human leukocyte antigen (HLA) DRB1*13
Blood oxygen level dependent (BOLD) signal in functional magnetic resonance imaging (fMRI) is frequently used as a proxy for underlying neural...
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Dependence of the heating effect on tissue absorption coefficient during corneal resha** using different UV lasers: A numerical study
Corneal resha** using laser ablation effect is a well-known ophthalmologic operation implemented to correct many vision disorders. UV pulsed lasers...
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HOXA9 gene promotor methylation and copy number variation of SOX2 and HV2 genes in cell free DNA: A potential diagnostic panel for non-small cell lung cancer
BackgroundMost cases of lung cancer are diagnosed at advanced stage. Detection of genetic and epigenetic markers in cell-free DNA (cfDNA) is a...
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Variation vs. specialization: the dose-time-effect of technical and physiological variety in the development of elite swimmers
ObjectiveIt is heavily discussed whether larger variety or specialization benefit elite performance at peak age. Therefore, this study aimed to...
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Analysis of Copy Number Variation in Urine: c-Myc Evaluation Using a Real-Time PCR Approach
Urine cell-free DNA has been shown as an informative noninvasive source of biomarkers for a number of diseases, especially for urological cancers....
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Gain and loss of TASK3 channel function and its regulation by novel variation cause KCNK9 imprinting syndrome
BackgroundGenomics enables individualized diagnosis and treatment, but large challenges remain to functionally interpret rare variants. To date, only...
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Proof of Concept in Assignment of Within-Subject Variability During Virtual Bioequivalence Studies: Propagation of Intra-Subject Variation in Gastrointestinal Physiology Using Physiologically Based Pharmacokinetic Modeling
While the concept of ‘Virtual Bioequivalence’ (VBE) using a combination of modelling, in vitro tests and integration of pre-existing data on systems...
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Controlling flat-foot limit cycle walkers with compliant joints based on local stability variation
This study investigates local stability of a four-link limit cycle walking biped with flat feet and compliant ankle joints. Local stability...
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A comparative study of passive drug diffusion through human skin via intercellular and sweat duct route: effect of aging
A method of drug delivery that could provide control over medicine reaching the bloodstream for systemic circulation would be of immense importance....
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Large variation in anti-factor Xa levels with nadroparin as thromboprophylaxis in COVID-19 and non-COVID-19 critically ill patients
PurposeCritically ill COVID-19 and non-COVID-19 patients receive thromboprophylaxis with the LMWH nadroparin. Whether a standard dosage is adequate...
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Gut microbiome variation modulates the effects of dietary fiber on host metabolism
BackgroundThere is general consensus that consumption of dietary fermentable fiber improves cardiometabolic health, in part by promoting mutualistic...
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Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the...
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Spatial and temporal variation of routine parameters: pitfalls in the cerebrospinal fluid analysis in central nervous system infections
The cerebrospinal fluid (CSF) space is convoluted. CSF flow oscillates with a net flow from the ventricles towards the cerebral and spinal...
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Morpho-Physiological and Molecular Characterization Reveal Low Genetic Variation for Conservation of Endangered Iranian Moshgak (Ducrosia anethifolia Boiss)
Ducrosia anethifolia Boiss is an aromatic vegetable and medicinal plant of Apiaceae family. In this study, morphological and essential oil studies as...
