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Novel clinical, molecular and bioinformatics insights into the genetic background of autism
BackgroundClinical classification of autistic patients based on current WHO criteria provides a valuable but simplified depiction of the true nature...
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Clinical Validation of the Medical Devices: A General Prospective
Over the years, the spectrum of medical devices has been diversified from very simple to the highly complex platform, simultaneously the risk factor...
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Proteomic advance of ischemic stroke: preclinical, clinical, and intervention
Ischemic stroke (IS) is the most common type of stroke and is characterized by high rates of mortality and long-term injury. The prediction and early...
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A clinical-radiomics nomogram based on spectral CT multi-parameter images for preoperative prediction of lymph node metastasis in colorectal cancer
To develop a clinical-radiomics nomogram based on spectral CT multi-parameter images for predicting lymph node metastasis in colorectal cancer. A...
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Clinical and biochemical characteristics, and outcome in 33 patients with ceftriaxone-induced liver injury
PurposeTo summarize the clinical and biochemical characteristics of patients with ceftriaxone-induced liver injury and guide the selection of safe...
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Clinical application of calcium silicate-based bioceramics in endodontics
Pulp treatment is extremely common in endodontics, with the main purpose of eliminating clinical symptoms and preserving tooth physiological...
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Image-guided programming deep brain stimulation improves clinical outcomes in patients with Parkinson’s disease
Deep brain stimulation (DBS) is an effective treatment for patients with Parkinson’s disease (PD). However, some patients may not respond optimally...
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Management of ulcerative colitis by dichloroacetate: Impact on NFATC1/NLRP3/IL1B signaling based on bioinformatics analysis combined with in vivo experimental verification
The inflammatory response in ulcerative colitis (UC) could be relieved by the conventional immunomodulatory agents; 5-aminosalicylic acid,...
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A framework for integrating artificial intelligence for clinical care with continuous therapeutic monitoring
The complex relationships between continuously monitored health signals and therapeutic regimens can be modelled via machine learning. However, the...
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Unveiling promising breast cancer biomarkers: an integrative approach combining bioinformatics analysis and experimental verification
BackgroundBreast cancer remains a significant health challenge worldwide, necessitating the identification of reliable biomarkers for early...
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Bioinformatics prediction and experimental verification identify MAD2L1 and CCNB2 as diagnostic biomarkers of rhabdomyosarcoma
BackgroundRhabdomyosarcoma (RMS) is a malignant soft-tissue tumour. In recent years, the tumour microenvironment (TME) has been reported to be...
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Physiologically Based Pharmacokinetic Modelling in Drug Discovery and Clinical Development: A Treatise on Concepts, Model Workflow, Credibility, Application and Regulatory Landscape
Physiologically based pharmacokinetic modelling (PBPK) approach considers the body as a multi-compartment system where physiological organs and...
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Identification of kukoamine a as an anti-osteoporosis drug target using network pharmacology and experiment verification
BackgroundOsteoporosis (OP) is a major and growing public health problem characterized by decreased bone mineral density and destroyed bone...
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Urinary Exosomal miRNAs as biomarkers of bladder Cancer and experimental verification of mechanism of miR-93-5p in bladder Cancer
BackgroundBladder cancer (BC) is one of the most common malignancies globally. Early diagnosis of it can significantly improve patients’ survival and...
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Clinical application of next generation sequencing for Mendelian disease diagnosis in the Iranian population
Next-generation sequencing (NGS) has been proven to be one of the most powerful diagnostic tools for rare Mendelian disorders. Several studies on the...
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An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer
BackgroundEndometrial cancer (EC) is one of the most common gynecological malignancies globally, and the development of innovative, effective drugs...
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Hsa-miR-877-5p Expression in Acute Ischemic Stroke Based on Bioinformatics Analysis and Clinical Validation
Inflammation and immunity play important roles in the pathogenesis of ischemic stroke. This study aimed to explore key regulatory genes in acute...
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Joint ABS-UKCGG-CanGene-CanVar consensus regarding the use of CanRisk in clinical practice
BackgroundThe CanRisk tool, which operationalises the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) is...
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Mutational spectrum and clinical features of GBA1 variants in a Chinese cohort with Parkinson’s disease
GBA1 variants are important risk factors for Parkinson’s disease (PD). Most studies assessing GBA1 -related PD risk have been performed in...
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Multimodal data-driven prognostic model for predicting new-onset ST-elevation myocardial infarction following emergency percutaneous coronary intervention
ObjectivesWe developed a nomogram model derived from inflammatory indices, clinical data, and imaging data to predict in-hospital major adverse...
