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Genetic Polymorphisms of Three DNA-Repair Genes (PRKDC, XPD, XRCC1) are Related to Colorectal Cancer Susceptibility
AbstractAlthough the specific causes of colorectal cancer (CRC) are not known, a robust DNA repair capacity may decrease the risk of this malignancy....
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Review on novel toxicological effects and personalized health hazard in workers exposed to low doses of benzene
Several recent reports indicate health hazards for workers with below occupational limit exposure to benzene (BZ). Our updated review indicates that...
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The evolutionary dynamics of extrachromosomal DNA in human cancers
Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving aggressive tumor growth, drug resistance and shorter survival....
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Targeting DNA-PK overcomes acquired resistance to third-generation EGFR-TKI osimertinib in non-small-cell lung cancer
The third-generation of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), represented by osimertinib, has achieved...
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Genome-wide DNA methylation reveals potential epigenetic mechanism of age-dependent viral susceptibility in grass carp
BackgroundGrass carp are an important farmed fish in China that are infected by many pathogens, especially grass carp reovirus (GCRV). Notably, grass...
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CDK5 promotes apoptosis and attenuates chemoresistance in gastric cancer via E2F1 signaling
BackgroundChemoresistance is a major clinical challenge that leads to tumor metastasis and poor clinical outcome. The mechanisms underlying gastric...
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Antimicrobial immunity impedes CNS vascular repair following brain injury
Traumatic brain injury (TBI) and cerebrovascular injury are leading causes of disability and mortality worldwide. Systemic infections often accompany...
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Novel frontiers in urogenital cancers: from molecular bases to preclinical models to tailor personalized treatments in ovarian and prostate cancer patients
Over the last few decades, the incidence of urogenital cancers has exhibited diverse trends influenced by screening programs and geographical...
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Radio-adaptive response and correlation of non-homologous end joining repair gene polymorphisms [XRRC5 (3R/2R/1R/0R), XRCC6(C/G) and XRCC7 (G/T)] in human peripheral blood mononuclear cells exposed to gamma radiation
BackgroundRadio-adaptive response (RAR) is transient phenomena, where cells conditioned with a small dose (priming) of ionizing radiation shows...
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Methods of Detection and Mechanisms of Origin of Complex Structural Genome Variations
Based on classical karyoty**, structural genome variations (SVs) have generally been considered to be either “simple” (with one or two breakpoints)...
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Discovery of novel acridine-chalcone hybrids with potent DNA binding and antiproliferative activity against MDA-MB-231 and MCF-7 cells
Two series of novel chalcone derivatives containing acridin-9-yl or acridin-4-yl moiety have been synthesized, structure elucidated and further...
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An immunochemistry-based screen for chemical inhibitors of DNA-protein interactions and its application to human CGGBP1
BackgroundInhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding...
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Applications of Decellularized Materials for Tissue Repair
The pursuit of tissue engineering and regenerative medicine is to regenerate functional tissues and organs to replace damaged or diseased tissue. As...
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DNA Double-Strand Break Accumulation in Alzheimer’s Disease: Evidence from Experimental Models and Postmortem Human Brains
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that accounts for a majority of dementia cases. AD is characterized by...
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Functional genetic variants of GEN1 predict overall survival of Chinese epithelial ovarian cancer patients
BackgroundInherited variations in DNA double-strand break (DSB) repair pathway are known to influence ovarian cancer occurrence, progression and...
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p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme
BackgroundGlioblastoma multiforme (GBM) is the most aggressive form of brain cancer, and chemoresistance poses a significant challenge to the...
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PARP1 negatively regulates transcription of BLM through its interaction with HSP90AB1 in prostate cancer
BackgroundProstate cancer (PCa) is a prevalent malignant disease affecting a significant number of males globally. Elevated expression of the Bloom’s...
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Functional and phenotypic consequences of an unusual inversion in MSH2
Lynch syndrome is an autosomal dominant disorder that usually results from a pathogenic germline variant in one of four genes ( MSH2 , MSH6 , MLH1 , PMS2 )...
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ICOS DNA methylation regulates melanoma cell-intrinsic ICOS expression, is associated with melanoma differentiation, prognosis, and predicts response to immune checkpoint blockade
BackgroundInducible T cell costimulator ICOS is an emerging target in immuno-oncology. The aim of this study was to investigate the epigenetic...
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The potential utility of hybrid photo-crosslinked hydrogels with non-immunogenic component for cartilage repair
Finding a suitable biomaterial for scaffolding in cartilage tissue engineering has proved to be far from trivial. Nonetheless, it is clear that...
