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Current Reserve Drugs
The incidence of resistance development against antimicrobial agents is increasing in Gram-negative bacteria (GNB) worldwide. This has resulted into...
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Dissemination of mcr-1 and β-lactamase genes among Pseudomonas aeruginosa: molecular characterization of MDR strains in broiler chicks and dead-in-shell chicks infections
ObjectivesPseudomonas aeruginosa ( P. aeruginosa) is one of the most serious pathogens implicated in antimicrobial resistance, and it has been...
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Phenotypic and genotypic analysis of antimicrobial resistance and population structure of gastroenteritis-related Aeromonas isolates
BackgroundThe population structure and the correlation between antimicrobial resistance (AMR) phenotypes and genotypes in Aeromonas species isolated...
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Impact of selective reporting of antibiotic susceptibility testing results on meropenem prescriptions for the treatment of Pseudomonas aeruginosa infections after 2020 EUCAST criteria update: an observational study in a university hospital
BackgroundWe previously reported an increase in meropenem prescriptions for Pseudomonas aeruginosa infections in our hospital after the...
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KPC-12 with a L169M substitution in the Ω loop has reduced carbapenemase activity
KPC-12 is a variant of KPC-2 with a L169M substitution in the Ω loop, but its resistance spectrum was not reported. bla KPC-12 was cloned, and KPC-12...
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Molecular determination of O25b/ST131 clone type among extended spectrum β-lactamases production Escherichia coli recovering from urinary tract infection isolates
BackgroundEscherichia coli (E. coli) O25b/ST131 clone causes urinary tract infection (UTI) and is associated with a broad spectrum of other...
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Genomic characterization of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) strains circulating in three university hospitals in Northern Italy over three years
ObjectivesGenomic surveillance of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) is crucial for virulence,...
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Third-generation cephalosporin resistant gram-negative bacteraemia in patients with haematological malignancy; an 11-year multi-centre retrospective study
ObjectivesAmong patients with haematological malignancy, bacteraemia is a common complication during chemotherapy-induced neutropenia. Resistance of...
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Infection with Carbapenem-resistant Hypervirulent Klebsiella Pneumoniae: clinical, virulence and molecular epidemiological characteristics
BackgroundCarbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is gradually becoming the dominant nosocomial pathogens in the...
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Assessment of antibiotic resistance changes during the Covid-19 pandemic in northeast of Iran during 2020–2022: an epidemiological study
BackgroundThe coronavirus disease 2019 seems to change antibiotic resistance pattern. Certain conditions in the Covid-19 era may be contributing to...
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Molecular characterization of extensively drug-resistant hypervirulent Pseudomonas aeruginosa isolates in China
BackgroundRecently, extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) isolates have been increasingly detected and posed great challenges...
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Contemporary analysis of ETEST for antibiotic susceptibility and minimum inhibitory concentration agreement against Pseudomonas aeruginosa from patients with cystic fibrosis
ObjectivesCystic fibrosis (CF) acute pulmonary exacerbations are often caused by Pseudomonas aeruginosa , including multi-drug resistant strains....
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Clinico-microbiological profile of Burkholderia cepacia keratitis: a case series
BackgroundBurkholderia cepacia , an opportunistic pathogen mainly affecting patients with cystic fibrosis or immunocompromised, has rarely been...
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Serious adverse events with novel beta-lactam/beta-lactamase inhibitor combinations: a large-scale pharmacovigilance analysis
The purpose of this study is to characterize adverse events (AEs) of clinical interest reported with ceftolozane-tazobactam and...
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Antibiotic Resistance Profile and Detection in ESKAPE Pathogens
Antibiotic resistance indicates the presence of a genetically determined resistance mechanism in bacteria to withstand or combat the lethal or...
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Antimicrobial susceptibility patterns of respiratory Gram-negative bacterial isolates from COVID-19 patients in Switzerland
BackgroundBacterial superinfections associated with COVID-19 are common in ventilated ICU patients and impact morbidity and lethality. However, the...
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In vitro activities of colistin, imipenem and ceftazidime against drug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii isolates in the south of Iran
ObjectiveThe present study aimed to determine in vitro activity of colistin and other agents against drug-resistant isolates of Pseudomonas...
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Interplay between Klebsiella pneumoniae producing KPC-31 and KPC-3 under treatment with high dosage meropenem: a case report
The objective was to study ceftazidime-avibactam resistant and susceptible Klebsiella pneumoniae isolated from a patient admitted to the Policlinico...
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Treatment for carbapenem-resistant Enterobacterales infections: recent advances and future directions
Carbapenem-resistant Enterobacterales (CRE) are a growing threat to human health worldwide. CRE often carry multiple resistance genes that limit...
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Colistin-, cefepime-, and levofloxacin-resistant Salmonella enterica serovars isolated from Egyptian chicken carcasses
ObjectivesThe emergence of multidrug-resistant (MDR) Salmonella strains, especially resistant ones toward critically important antimicrobial classes...
