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Integrative evaluation and experimental validation of the immune-modulating potential of dysregulated extracellular matrix genes in high-grade serous ovarian cancer prognosis
BackgroundHigh-grade serous ovarian cancer (HGSOC) is a challenging malignancy characterized by complex interactions between tumor cells and the...
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The Carcinogen Glycidol and Use of N-(2,3-Dihydroxypropyl)-valine in Hemoglobin as a Biomarker of Exposure
Fatty acid esters of glycidol (glycidyl esters, GE) are processing contaminants in vegetable oils and fats. GE release the carcinogenic glycidol in...
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Validation in Zambia of a cervical screening strategy including HPV genoty** and artificial intelligence (AI)-based automated visual evaluation
BackgroundWHO has recommended HPV testing for cervical screening where it is practical and affordable. If used, it is important to both clarify and...
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Regulation of Agrochemicals
Plant protection products (PPPs) have to be authorized prior to their placing on the market. PPPs may only contain active substances (or safeners and...
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Temporal trend of gastric cancer burden along with its risk factors in China from 1990 to 2019, and projections until 2030: comparison with Japan, South Korea, and Mongolia
BackgroundIdentifying and projecting the epidemiological burden of gastric cancer (GC) can optimize the control strategies, especially in high-burden...
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Sunlight exposure in association with risk of lymphoid malignancy: a meta-analysis of observational studies
PurposeSeveral observational studies have shown contradictory results regarding the association between sunlight exposure and the risk of malignant...
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Commentary: the chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation
Recently, Borm and Driscoll published a commentary discussing grou** of Poorly Soluble particles of Low Toxicity (PSLTs) and the use of rats as an...
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Regulation of Agrochemicals
Plant protection products (PPPs) have to be authorized prior to their placing on the market. PPPs may only contain active substances (or safeners and...
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Environmental and Occupational Exposure to Pesticides and Cancer Development
Over the past few decades, number of cancer cases attributed to environmental and occupational carcinogens of asbestos, arsenic, pesticides, and...
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A novel in-situ method to determine the respiratory tract deposition of carbonaceous particles reveals dangers of public commuting in highly polluted megacity
BackgroundExposure to air pollutants is one of the major environmental health risks faced by populations globally. Information about inhaled particle...
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Experimental Model for Pancreatic Cancer and Its Therapeutic Implications in Clinical Research
This book chapter aims to provide an overview knowledge on different animal models that has wide range of research implications in pancreatic cancer...
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Benzo(a)Pyrene Induced ROS-Mediated Lung Cancer
Lung cancer is the world’s second-largest cause of death from cancer. Cigarette smoking is identified as one of the single, well-known risk factors...
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Biomarkers of lipid metabolism in gastric cancer: a case control study
BackgroundThe aim of this study was to explore the correlation between biomarkers of lipid metabolism and gastric cancer.
Methods1120 gastric cancer...
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Global burden of cancers attributable to tobacco smoking, 1990–2019: an ecological study
Aim and backgroundIdentifying risk factors for cancer initiation and progression is the cornerstone of the preventive approach to cancer management...
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Identification of a novel signature based on unfolded protein response-related gene for predicting prognosis in bladder cancer
BackgroundThe unfolded protein response (UPR) served as a vital role in the progression of tumors, but the molecule mechanisms of UPR in bladder...
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Circulating vitamin D level before initiating chemotherapy impacts on the time-to-outcome in metastatic colorectal cancer patients: systematic review and meta-analysis
BackgroundVitamin D (VD) is implicated in various health conditions, including colorectal cancer (CRC). To investigate potential relationships...
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Quantifying substantial carcinogenesis of genetic and environmental factors from measurement error in the number of stem cell divisions
BackgroundThe relative contributions of genetic and environmental factors versus unavoidable stochastic risk factors to the variation in cancer risk...
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Impacts of PAH accumulation on reproductive hormones, indices of oxidative stress and BPDE-albumin adduct in women with recurrent pregnancy loss
Chronic exposure to Poly aromatic hydrocarbons (PAHs) may be associated with adverse pregnancy outcomes. Disruption of hormonal and redox balance by...
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Alcohol consumption and cancer incidence in women: interaction with smoking, body mass index and menopausal hormone therapy
BackgroundAlcohol consumption has been associated with increased risks of certain site-specific cancers and decreased risks of some other cancers....
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Optimized screening of DNA methylation sites combined with gene expression analysis to identify diagnostic markers of colorectal cancer
BackgroundThe prognosis of patients with colorectal cancer is related to early detection. However, commonly used screening markers lack sensitivity...
