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Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
BackgroundAbout 25% of patients with acute hepatitis C virus (HCV) infection show spontaneous clearance within the first six months of infection but...
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Pharmacogenomics of Alzheimer’s Disease: Novel Strategies for Drug Utilization and Development
Alzheimer’s disease (AD) is a priority health problem in developed countries with a high cost to society. Approximately 20% of direct costs are...
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Technology-based therapy-response and prognostic biomarkers in a prospective study of a de novo Parkinson’s disease cohort
Early noninvasive reliable biomarkers are among the major unmet needs in Parkinson’s disease (PD) to monitor therapy response and disease...
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Acyloxyacyl hydrolase deficiency induces chronic inflammation and bone loss in male mice
AbstractHormonal homeostasis is essential in bone remodeling. Recent studies have shown that the treatment of intestinal inflammation can result in...
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Gut–Brain Axis in Alzheimer’s Disease: Interplay Between Cholecystokinin, Dysbiosis, and Brain-Derived Neurotrophic Factor
The relationship between metabolic profile and the structural integrity of the brain in Alzheimer’s disease (AD) patients is of particular interest....
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CRISPR/Cas-based CAR-T cells: production and application
Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized the treatment approach for cancer, autoimmune disease, and heart disease. The...
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Proteomic advance of ischemic stroke: preclinical, clinical, and intervention
Ischemic stroke (IS) is the most common type of stroke and is characterized by high rates of mortality and long-term injury. The prediction and early...
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Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation
Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet...
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Interaction between PD-L1 and soluble VEGFR1 in glioblastoma-educated macrophages
PurposeThe combined application of immune checkpoint inhibitors (ICIs) and anti-angiogenesis therapy has shown synergistic effects on glioblastoma...
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Association study identifies genetic determinants and non-genetic factors on steady-state plasma and therapeutic outcome of galantamine in mixed dementia
PurposeThis study aimed to evaluate the influence of genetic polymorphisms of drug-metabolizing enzyme genes, transporter gene, pathological gene ( APOE...
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Let-7b-TLR7 Signaling Axis Contributes to the Anesthesia/Surgery-Induced Cognitive Impairment
Perioperative neurocognitive disorders (PNDs) are severe and common neurological complications among elderly patients following anesthesia and...
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Reduced expression of semaphorin 3A in osteoclasts causes lymphatic expansion in a Gorham-Stout disease (GSD) mouse model
Gorham-Stout disease (GSD) is a sporadic chronic disease characterized by progressive bone dissolution, absorption, and disappearance along with...
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Inhibition of NADPH oxidase 2 enhances resistance to viral neuroinflammation by facilitating M1-polarization of macrophages at the extraneural tissues
BackgroundMacrophages play a pivotal role in the regulation of Japanese encephalitis (JE), a severe neuroinflammation in the central nervous system...
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Protein network and pathway analysis in a pharmacogenetic study of cyclosporine treatment response in Greek patients with psoriasis
Although cyclosporine comprises a well-established systemic therapy for psoriasis, patients show important heterogeneity in their treatment response....
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Mucopolysaccharidoses and the blood–brain barrier
Mucopolysaccharidoses comprise a set of genetic diseases marked by an enzymatic dysfunction in the degradation of glycosaminoglycans in lysosomes....
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Age-adjusted high-dose chemotherapy followed by autologous stem cell transplantation or conventional chemotherapy with R-MP as first-line treatment in elderly primary CNS lymphoma patients – the randomized phase III PRIMA-CNS trial
BackgroundOlder primary central nervous system lymphoma (PCNSL) patients have an inferior prognosis compared to younger patients because available...
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Long Non-coding RNA ANRIL and Its Role in the Development of Age-Related Diseases
ANRIL is known as a lncRNA that has many linear and circular isoforms and its polymorphisms are observed to be associated with the pathogenesis of...
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The impact of Alzheimer's disease susceptibility loci on lateral ventricular surface morphology in older adults
The enlargement of ventricular volume is a general trend in the elderly, especially in patients with Alzheimer’s disease (AD). Multiple...
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Effects of leptin-modified human placenta-derived mesenchymal stem cells on angiogenic potential and peripheral inflammation of human umbilical vein endothelial cells (HUVECs) after X-ray radiation
Combined radiation-wound injury (CRWI) is characterized by blood vessel damage and pro-inflammatory cytokine deficiency. Studies have identified that...
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Strategies for develo** Alzheimer’s disease treatments: application of population pharmacokinetic and pharmacodynamic models
BackgroundAs the number of Alzheimer's disease (AD) patients steadily increases, many pharmaceutical industries and researchers are making efforts...