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Alpha-synuclein Immunization Strategies for Synucleinopathies in Clinical Studies: A Biological Perspective
The therapeutic strategies currently available for neurodegenerative diseases such as Parkinson’s disease target only the symptoms of the disease....
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Immunogenetic Factors in the Pathogenesis of Schizophrenia
AbstractHuman predisposition to neurological diseases such as schizophrenia, Alzheimer’s, Parkinson’s and other neuropathologies is associated with...
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Engineering Nanobody Targeting Cancer Stem Cells
Nanobodies (Nbs) are great molecular tools that can circumvent the limitations of traditional antibodies such as large size, low stability, slow...
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Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities
High-risk groups, including Indigenous people, are at risk of severe COVID-19. Here we found that Australian First Nations peoples elicit effective...
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Artificial intelligence-powered discovery of small molecules inhibiting CTLA-4 in cancer
Background/ObjectivesCheckpoint inhibitors, which generate durable responses in many cancer patients, have revolutionized cancer immunotherapy....
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A comprehensive comparison between camelid nanobodies and single chain variable fragments
By the emergence of recombinant DNA technology, many antibody fragments have been developed devoid of undesired properties of natural...
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Combined Analysis of Transcriptome and T-Cell Receptor Alpha and Beta (TRA /TRB ) Repertoire in Paucicellular Samples at the Single-Cell Level
With the advent of next-generation sequencing (NGS) methodologies, the total repertoires of B and T cells can be disclosed in much more detail than...
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HLA imputation and its application to genetic and molecular fine-map** of the MHC region in autoimmune diseases
Variations of human leukocyte antigen (HLA) genes in the major histocompatibility complex region (MHC) significantly affect the risk of various...
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Multiple Immune Defects in Two Patients with Novel DOCK2 Mutations Result in Recurrent Multiple Infection Including Live Attenuated Virus Vaccine
The dedicator of cytokinesis 2(DOCK2) protein, an atypical guanine nucleotide exchange factor (GEFs), is a member of the DOCKA protein subfamily....
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Adaptive Immunity and Antigen Receptor Diversity
This chapter will provide an overview on the roles of B and T cells in the response of the adaptive immune system to microbe invasion. In this...
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Isolation and characterization of camelid single-domain antibodies against HER2
ObjectiveTo isolate and characterize novel high-affinity llama single-domain antibodies against human HER2.
ResultsWe immunized a llama with human...
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The Expression of Non B Cell-Derived Immunoglobulins
Although V(D)J recombination and immunoglobulin (Ig) production are traditionally recognised to occur only in B lymphocytes and plasma cells, the...
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Construction of a Mouse-Feline Chimeric Neutralizing Antibody Against SARS-CoV-2
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become the biggest challenge in public health...
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Dual T-cell constant β chain (TRBC)1 and TRBC2 staining for the identification of T-cell neoplasms by flow cytometry
The diagnosis of leukemic T-cell malignancies is often challenging, due to overlap** features with reactive T-cells and limitations of currently...
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Genetic and Functional Identifying of Novel STAT1 Loss-of-Function Mutations in Patients with Diverse Clinical Phenotypes
PurposeMutations in signal transducer and activator of transcription 1 (STAT1) cause a broad spectrum of disease phenotypes. Heterozygous STAT1 ...
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Development of a neutralization monoclonal antibody with a broad neutralizing effect against SARS-CoV-2 variants
BackgroundThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has challenged the effectiveness of current...
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Revealing factors determining immunodominant responses against dominant epitopes
Upon recognition of peptide-MHC complexes by T cell receptors (TCR), the cognate T cells expand and differentiate into effector T cells to generate...
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Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies
The antibody repertoire of Bos taurus is characterized by a subset of variable heavy (VH) chain regions with ultralong third complementarity...
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The Therapeutic Effect of an Anti-TNF-α/HSA/IL-6R Triple-Specific Fusion Protein Under Experimental Septic Conditions
Sepsis caused by a dysregulated host response to infection is a life-threatening disease that can lead to organ dysfunction. Due to its unclear and...
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