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Central regulation of stress-evoked peripheral immune responses
Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are associated with systemic inflammation. Recent studies have...
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Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases
Cardiovascular diseases (CVDs) are a leading factor driving mortality worldwide. Iron, an essential trace mineral, is important in numerous...
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Donepezil attenuates injury following ischaemic stroke by stimulation of neurogenesis, angiogenesis, and inhibition of inflammation and apoptosis
Donepezil has proven to be an effective drug to reduce neuronal death and subsequently injury in neurodegenerative diseases. The current study...
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Retinal imaging technologies in cerebral malaria: a systematic review
BackgroundCerebral malaria (CM) continues to present a major health challenge, particularly in sub-Saharan Africa. CM is associated with a...
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S1PR3 inhibition protects against LPS-induced ARDS by inhibiting NF-κB and improving mitochondrial oxidative phosphorylation
BackgroundInflammation and endothelial barrier dysfunction are the major pathophysiological changes in acute respiratory distress syndrome (ARDS)....
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Disengaging the COVID-19 Clutch as a Discerning Eye Over the Inflammatory Circuit During SARS-CoV-2 Infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the cytokine release syndrome (CRS) and leads to multiorgan dysfunction....
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A signaling network map of Lipoxin (LXA4): an anti-inflammatory molecule
Lipoxins (LXs) are a class of endogenous bioactive lipid mediators that are involved in the regulation of inflammation. They exert immunomodulatory...
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Beneficial Effect of Sodium Nitrite on EEG Ischaemic Markers in Patients with Subarachnoid Haemorrhage
Subarachnoid haemorrhage (SAH) is associated with long-term disability, serious reduction in quality of life and significant mortality. Early brain...
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Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside
Cell therapies are emerging as promising treatments for a range of liver diseases but translational bottlenecks still remain including: securing and...
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Pharmacological update of mirtazapine: a narrative literature review
Mirtazapine (MTZ) is an antidepressant drug with an exceptional pharmacological profile. It also has an excellent safety and tolerability profile....
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The redox-active defensive Selenoprotein T as a novel stress sensor protein playing a key role in the pathophysiology of heart failure
Maladaptive cardiac hypertrophy contributes to the development of heart failure (HF). The oxidoreductase Selenoprotein T (SELENOT) emerged as a key...
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Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway
BackgroundIschaemia reperfusion (IR) induces multiple pathophysiological changes. In addition to its classical role in regulating tumourigenesis, the...
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Macroautophagy in CNS health and disease
Macroautophagy is an evolutionarily conserved process that delivers diverse cellular contents to lysosomes for degradation. As our understanding of...
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A guide to complement biology, pathology and therapeutic opportunity
Complement has long been considered a key innate immune effector system that mediates host defence and tissue homeostasis. Yet, growing evidence has...
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Ethnopharmacology, Phytochemistry, and Pharmacology of Ashtanga Ghrita: an Ayurvedic Polyherbal Formulation for Neurological Disorders
Purpose of ReviewAyurveda is an ancient Indian medical system with unique approaches for the treatment of various brain disorders. Ashtanga Ghrita ,...
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DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways
Damage-associated molecular patterns (DAMPs) are endogenous molecules that are released from host cells as a result of cell death or damage. The...
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Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer
A large body of evidence indicates the existence of a complex pathophysiological relationship between cardiovascular diseases and cancer....
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Crocin enhances hypothermia therapy in hypoxic ischemia-induced brain injury in mice
Hypoxic–ischemic encephalopathy (HIE) is a serious medical situation at labor which leads to severe brain damage. Hypothermia therapy is the standard...
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The immune response of T cells and therapeutic targets related to regulating the levels of T helper cells after ischaemic stroke
Through considerable effort in research and clinical studies, the immune system has been identified as a participant in the onset and progression of...
