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Trimethylamine, a gut bacteria metabolite and air pollutant, increases blood pressure and markers of kidney damage including proteinuria and KIM-1 in rats
BackgroundTrimethylamine oxide (TMAO) is a biomarker in cardiovascular and renal diseases. TMAO originates from the oxidation of trimethylamine...
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The potential impact of a probiotic: Akkermansia muciniphila in the regulation of blood pressure—the current facts and evidence
Akkermansia muciniphila ( A. muciniphila ) is present in the human gut microbiota from infancy and gradually increases in adulthood. The potential...
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Low Concordance Between Blood Pressures Measured in Periodic Health Examinations and in a Workplace-Based Hypertension Management Program
Poor adherence to standard protocols of blood pressure (BP) measurement in routine clinical practice leads to higher readings than “research-quality”...
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Effect of Cholecystokinin-8 (CCK-8) on Blood Pressure and Blood Content of Calcitonin-Gene-Related Peptide (CGRP) in Rats with Hypertension Caused by Fructose or Inhibition of Nitric Oxide Synthesis
We studied the effect of CCK-8 on BP and blood content of CGRP in rats with hypertension caused by fructose or inhibition of NO synthase with L-NAME....
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Brachial and central blood pressure and arterial stiffness in adult elite athletes
PurposeMeasures of arterial stiffness (AS) and central blood pressure (BP) are indicators for cardiovascular health and possess a high prognostic...
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Expression of Trpa1 and Trpv1 Genes in the Hypothalamus and Blood Pressure in Normotensive and Hypertensive Rats. Effect of Losartan and Captopril
Analysis of the role of genomic regulation of systolic BP (SBP) in normal and hypertensive rats showed the presence of an inverse relationship...
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Cardiac sympathetic burden reflects Parkinson disease burden, regardless of high or low orthostatic blood pressure changes
Reduced uptake of 123 I- meta -iodobenzylguanidine ( 123 I-MIBG) and orthostatic hypotension (OH) are independently associated with worse clinical...
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Treatment of male and female spontaneously hypertensive rats with TNF-α inhibitor etanercept increases markers of renal injury independent of an effect on blood pressure
Hypertension remains the leading risk factor for cardiovascular disease. Young females tend to be protected from hypertension compared with...
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Genetic susceptibility, elevated blood pressure, and risk of atrial fibrillation: a Mendelian randomization study
BackgroundWhether elevated blood pressure (BP) is a modifiable risk factor for atrial fibrillation (AF) is not established. We tested (1) whether the...
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Attenuated spontaneous postural sway enhances diastolic blood pressure during quiet standing
PurposeSpontaneous postural sway during quiet standing has been considered a simple output error of postural control. However, as postural sway and...
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Genetically determined blood pressure, antihypertensive medications, and risk of Alzheimer’s disease: a Mendelian randomization study
BackgroundObservational studies suggest that the use of antihypertensive medications (AHMs) is associated with a reduced risk of Alzheimer’s disease...
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Effect of transmural pressure on the estimation of arterial stiffness index from the photoplethysmographic waveform
The aim of this study was to find the effect of transmural pressure on the determination of the photoplethysmographic (PPG) waveform arterial...
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Sex differences in workload-indexed blood pressure response and vascular function among professional athletes and their utility for clinical exercise testing
PurposeSex differences in blood pressure (BP) regulation at rest have been attributed to differences in vascular function. Further, arterial...
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The effects of water temperature on cerebral blood flow during aquatic exercise
PurposeRecent studies suggest that episodic increases in cerebral blood flow (CBF) may contribute to the improvement in brain health associated with...
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Mendelian randomization analysis of vitamin D in the secondary prevention of hypertensive-diabetic subjects: role of facilitating blood pressure control
BackgroundVitamin D (Vit-D) promotes vascular repair and its deficiency is closely linked to the development of type 2 diabetes mellitus (T2DM) and...
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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3...
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Association of blood pressure with cognitive function at midlife: a Mendelian randomization study
BackgroundWhether high blood pressure has a causal effect on cognitive function as early as middle age is unclear. We investigated whether high blood...
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Effect of normobaric hypoxic exercise on blood pressure in old individuals
PurposeTo test the hypothesis that the combination of endurance training and hypoxia leads to greater improvements in resting and exercise blood...
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Recreational beach tennis reduces 24-h blood pressure in adults with hypertension: a randomized crossover trial
PurposeTo evaluate the effect of a beach tennis session on 24-h ambulatory blood pressure in adults with hypertension.
MethodsIn this randomized...
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Increased cerebral vascular resistance underlies preserved cerebral blood flow in response to orthostasis in humans on a high-salt diet
Cerebral blood flow autoregulation protects brain tissue from blood pressure variations and maintains cerebral perfusion pressure by changes in...
