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Comparative analysis of glycated haemoglobin, fasting blood glucose and haematological parameters in Type-2 diabetes patients
ObjectiveDiabetes remains a major health problem, and Glycated hemoglobin (HBA1c) and fasting blood glucose (FBG) levels play important roles in its...
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Association of the tissue infiltrated and peripheral blood immune cell subsets with response to radiotherapy for rectal cancer
BackgroundTumor microenvironment plays pivotal roles in carcinogenesis, cancer development and metastasis. Composition of cancer immune cell subsets...
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An optimised YOLOv4 deep learning model for efficient malarial cell detection in thin blood smear images
BackgroundMalaria is a serious public health concern worldwide. Early and accurate diagnosis is essential for controlling the disease’s spread and...
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Study on the mechanism of Panax notoginseng–Salvia miltiorrhiza herb pair on invigorating blood circulation and eliminating blood stasis by blocking the conversion of arachidonic acid to prostaglandin
We combined untargeted and targeted metabolomics to explore the mechanism of blood circulation and blood stasis activation in the traditional Chinese...
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Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2/ET-1 axis-controlled ERK1/2 pathway
BackgroundNADPH oxidase (NOX), a primary source of endothelial reactive oxygen species (ROS), is considered a key event in disrupting the integrity...
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Partial recovery of peripheral blood monocyte subsets in head and neck squamous cell carcinoma patients upon radio(chemo)therapy is associated with decreased plasma CXCL11
BackgroundHead and neck squamous cell carcinoma (HNSCC) represents a common and heterogeneous malignancy of the oral cavity, pharynx and larynx....
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Peripheral blood lymphocytes differentiation patterns in responses / outcomes to immune checkpoint blockade therapies in non-small cell lung cancer: a retrospective study
ObjectivesProgrammed Cell Death-1/ Programmed Death-ligand 1 (PD-1 / PD-L1) inhibitor therapies targeting immunocytes induce persistent tumor...
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Islet Inflammation and β Cell Dysfunction in Type 2 Diabetes
Pancreatic islets are the body’s central rheostat that regulates glucose homeostasis through the production of different hormones, including β...
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Culture of Continuous Cell Lines
This chapter describes the culture of various continuous cell lines. Continuous cell lines are generated either due to specific genetic or epigenetic...
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Analysis of Human Peripheral Blood Mononuclear Cells in Patients with Neurodegenerative Diseases
The role of immune system in the progression of neurodegenerative diseases has been studied for decades in animal models. However, invasive studies...
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miRNA Theranostic Nanoparticles Promote Pancreatic Beta Cell Proliferation in Type 1 Diabetes Model
Type 1 diabetes (T1D) is a chronic autoimmune disorder which affects the insulin-producing beta cells in the pancreas. A variety of strategies,...
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Investigating neonatal health risk variables through cell-type specific methylome-wide association studies
Adverse neonatal outcomes are a prevailing risk factor for both short- and long-term mortality and morbidity in infants. Given the importance of...
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HArmonized single-cell RNA-seq Cell type Assisted Deconvolution (HASCAD)
BackgroundCell composition deconvolution (CCD) is a type of bioinformatic task to estimate the cell fractions from bulk gene expression profiles,...
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Perfluorocarbon-based artificial oxygen carriers for red blood cell substitutes: considerations and direction of technology
BackgroundRecently, the development of an artificial oxygen carrier that can replace blood transfusions is gaining attention, particularly in...
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Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease characterized by the development of arteriovenous malformations (AVMs)...
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Single-Cell Transcriptome Reveals Cell Type–Specific Molecular Pathology in a 2VO Cerebral Ischemic Mouse Model
Post-ischemia memory impairment is a major sequela in cerebral ischemia patients. However, cell type–specific molecular pathology in the hippocampus...
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Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach
Severe dengue (SD) is a major cause of morbidity and mortality. To define dengue virus (DENV) target cells and immunological hallmarks of SD...
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Detection of Cancer Stem Cells in Normal and Dysplastic/Leukemic Human Blood
The hierarchical organization of the leukemic stem cells (LSCs) is identical to that of healthy counterpart cells. It may be split into roughly three...
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Common Reagents and Medium for Mammalian Cell Culture
This chapter describes all common materials and reagents necessary for mammalian cell culture. Mammalian cells are normally present in tissues and...
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Detecting cord blood cell type-specific epigenetic associations with gestational diabetes mellitus and early childhood growth
BackgroundEpigenome-wide association studies (EWAS) have provided opportunities to understand the role of epigenetic mechanisms in development and...
