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Load Distribution at the Patellofemoral Joint During Walking
We combined computational modelling with experimental gait data to describe and explain load distribution across the medial and lateral facets of the...
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Structure and function of Achilles and patellar tendons following moderate slow resistance training in young and old men
The aim of this study was to investigate the effect of aging and resistance training with a moderate load on the size and mechanical properties of...
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Functional and Neuromuscular Aspects of Spaceflight
The extreme environment of reduced gravity and radiation exposure are among the main reasons for scientists’ concern for the harmful consequences to...
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TUBB3 Arg262His causes a recognizable syndrome including CFEOM3, facial palsy, joint contractures, and early-onset peripheral neuropathy
Microtubules are formed from heterodimers of alpha- and beta-tubulin, each of which has multiple isoforms encoded by separate genes. Pathogenic...
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Cerebral ventriculomegaly in myotonic dystrophy type 1: normal pressure hydrocephalus-like appearances on magnetic resonance imaging
BackgroundCerebral ventriculomegaly is an abnormal feature characteristic of myotonic dystrophy type 1 (DM1). This retrospective study investigated...
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Muscle and bone characteristics of a Chinese family with spinal muscular atrophy, lower extremity predominant 1 (SMALED1) caused by a novel missense DYNC1H1 mutation
BackgroundSpinal muscular atrophy, lower extremity predominant (SMALED) is a type of non-5q spinal muscular atrophy characterised by weakness and...
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A Novel De Novo TUBB3 Variant Causing Developmental Delay, Epilepsy and Mild Ophthalmological Symptoms in a Chinese Child
Heterozygous missense mutations in TUBB3 have been implicated in various neurological disorders encompassing either isolated congenital fibrosis of...
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Do poles really “save the legs” during uphill pole walking at different intensities?
PurposeIn sky- and trail-running competitions, many athletes use poles. The aims of this study were to investigate whether the use of poles affects...
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Electrical Properties of Adult Mammalian Motoneurons
Motoneurons are the ‘final common path’ between the central nervous system (that intends, selects, commands, and organises movement) and muscles...
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Spinal cord imaging markers and recovery of standing with epidural stimulation in individuals with clinically motor complete spinal cord injury
Spinal cord epidural stimulation (scES) is an intervention to restore motor function in those with severe spinal cord injury (SCI). Spinal cord...
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Ataxia in a Movement Disorders Outpatient Clinic: a Single-Center Experience in Turkey
The etiology may not be determined in patients with ataxia despite detailed evaluations. The aim of this study was to investigate the clinical and...
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Imaging Skeletal Muscle by Magnetic Resonance Imaging (MRI)
Skeletal muscle comprises a significant proportion of whole-body mass, and its maintenance is critical to the quality of life, particularly with...
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Unfolding the ventral nerve center of chaetognaths
BackgroundChaetognaths are a clade of marine worm-like invertebrates with a heavily debated phylogenetic position. Their nervous system superficially...
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Analysis of Skeletal Muscle Mass from Preexisting Computerized Tomography (CT) Scans
Computerized tomography (CT) is a gold standard imaging technique for assessing body composition at the tissue-organ level, particularly for the...
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Contribution of the Antiepileptic Drug Administration Regime to Avoid the Development and/or Establishment of Pharmacoresistant Epilepsy
Although drug-resistant epilepsy has been explained by different mechanisms, the most accepted one involves overexpression of efflux transporters at...
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Imaging Biomarkers in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a group of heterogeneous disorders characterized by degenerative changes in upper motor neurons within the...
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Evaluation of two upper-limb exoskeletons during overhead work: influence of exoskeleton design and load on muscular adaptations and balance regulation
PurposeOverhead works (OHW) are identified as a major risk factor for shoulder musculoskeletal disorders. The use of upper-limb exoskeletons (EXO UL )...
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Cortical Motor Control
The localization of motor functions within the cerebral cortex has a long history, dating back to the demonstration in 1870 by Fritsch and Hitzig...