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Specification and Plasticity of Mammalian Cochlear Hair Cell Progenitors
The mammalian cochlea detects and transduces auditory stimuli in the environment through sensory hair cells (HCs). Unlike non-mammalian species,...
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Cell Biology of the Synapse
Synapses are the sites of contact between nerve cells. Synapses convert electrical signals into chemical information, which is conveyed between...
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Penicillin-binding proteins: the master builders and breakers of bacterial cell walls and its interaction with β-lactam antibiotics
Penicillin-binding proteins (PBPs) have been the subject of analysis for over 40 years. These proteins play a crucial role in catalyzing...
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Iron metabolism: backfire of cancer cell stemness and therapeutic modalities
Cancer stem cells (CSCs), with their ability of self-renewal, unlimited proliferation, and multi-directional differentiation, contribute to...
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The Transcription Factors Zeb1 and Snail Induce Cell Malignancy and Cancer Stem Cell Phenotype in Prostate Cells, Increasing Androgen Synthesis Capacity and Therapy Resistance
Prostate cancer (PCa) incidence has increased during the last decades, becoming one of the leading causes of death by cancer in men worldwide. During...
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Metabolism-Redox Interplay in Tumor Stem Cell Signaling
Cancer stem cells (CSCs) are defined as a subpopulation of cells within the heterogeneous tumor mass endowed with the ability to self-renew and...
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Challenges for Place and Grid Cell Models
This chapter gives a short overview of computational models dealing with two fundamental building blocks in spatial cognition: grid and place cells,...
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Single cell RNA-seq analysis reveals temporally-regulated and quiescence-regulated gene expression in Drosophila larval neuroblasts
The mechanisms that generate neural diversity during development remains largely unknown. Here, we use scRNA-seq methodology to discover new features...
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The Golgi complex: An organelle that determines urothelial cell biology in health and disease
The Golgi complex undergoes considerable structural remodeling during differentiation of urothelial cells in vivo and in vitro. It is known that in a...
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Depletion of transit amplifying cells in the adult brain does not affect quiescent neural stem cell pool size
Neural stem cells (NSCs) are maintained in the adult mammalian brain throughout the animal’s lifespan. NSCs in the subependymal zone infrequently...
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Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B
Cancer stem cells (CSCs) are a subpopulation of cancer cells endowed with high tumorigenic, chemoresistant and metastatic potential. Nongenetic...
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Ubiquitous Merkel Cell Polyomavirus: Causative Agent of the Rare Merkel Cell Carcinoma
Merkel Cell polyomavirus (MCPyV) isMerkel Cell polyomavirus (MCPyV) the only member of the Polyomaviridae family that is directly linked to a type of...
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Embryonic Neurogenesis in the Mammalian Brain
The mammalian brain is probably the most fascinating and complex organ that has evolved over millions of years. In this chapter, we learn about some...
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PARD3 drives tumorigenesis through activating Sonic Hedgehog signalling in tumour-initiating cells in liver cancer
BackgroundPar-3 Family Cell Polarity Regulator (PARD3) is a cellular protein essential for asymmetric cell division and polarized growth. This study...
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‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses
Virus-specific CD8 + T cells that differentiate in the context of resolved versus persisting infections exhibit divergent phenotypic and functional...
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Human embryonic genetic mosaicism and its effects on development and disease
Nearly every mammalian cell division is accompanied by a mutational event that becomes fixed in a daughter cell. When carried forward to additional...
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Transcriptional regulation of cancer stem cell: regulatory factors elucidation and cancer treatment strategies
Cancer stem cells (CSCs) were first discovered in the 1990s, revealing the mysteries of cancer origin, migration, recurrence and drug-resistance from...
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Tumor matrix stiffness provides fertile soil for cancer stem cells
Matrix stiffness is a mechanical characteristic of the extracellular matrix (ECM) that increases from the tumor core to the tumor periphery in a...
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Clostridioides difficile Sporulation
Some members of the Firmicutes phylum, including many members of the human gut microbiota, are able to differentiate a dormant and highly resistant...