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Clinical and Immunological Features of SARS-CoV-2 Breakthrough Infections in Vaccinated Individuals Requiring Hospitalization
Background and PurposeWaning immunity and the surge of SARS-CoV-2 variants are responsible for breakthrough infections, i.e., infections in fully...
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IL-38, a potential therapeutic agent for lupus, inhibits lupus progression
BackgroundPrevious studies reported that IL-38 was abnormally expressed in patients with systemic lupus erythematosus (SLE). However, the involvement...
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SARS-CoV-2 antibodies in inflammatory neurological conditions: a multicentre retrospective comparative study
It is well established that neurological and non-neurological autoimmune disorders can be triggered by viral infections. It remains unclear whether...
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Plasma angiotensin peptides as biomarkers of rheumatoid arthritis are correlated with anti-ACE2 auto-antibodies level and disease intensity
BackgroundThis study aimed to explore a correlation between plasma angiotensin II/(1–7) (Ang II/Ang-(1–7)) ratio, anti-ACE2 autoantibodies level and...
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Regulation of macrophage polarization by targeted metabolic reprogramming for the treatment of lupus nephritis
Lupus nephritis (LN) is a severe and common manifestation of systemic lupus erythematosus (SLE) that is frequently identified with a poor prognosis....
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Evaluation of Genetic or Cellular Impairments in Type I IFN Immunity in a Cohort of Young Adults with Critical COVID-19
Several genetic and immunological risk factors for severe COVID-19 have been identified, with monogenic conditions relating to 13 genes of type I...
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Adaptive Immunity and the Clinical Definition of Autoantibodies
Detection of autoantibodies in the patient’s serum is a key diagnostic tool in autoimmune liver diseases, provided that the clinician is familiar...
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Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients
BackgroundComprehensive data on the cerebrospinal fluid (CSF) profile in patients with COVID-19 and neurological involvement from large-scale...
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Lupus progression deteriorates oogenesis quality in MRL/lpr mice
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of the immune response against self antigens. Numerous...
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Blocking interleukin-23 ameliorates neuromuscular and thymic defects in myasthenia gravis
Acetylcholine receptor (AChR) myasthenia gravis (MG) is a chronic autoimmune disease characterized by muscle weakness. The AChR + autoantibodies are...
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Human serum-derived α-synuclein auto-antibodies mediate NMDA receptor-dependent degeneration of CNS neurons
BackgroundPresence of autoantibodies against α-synuclein (α-syn AAb) in serum of the general population has been widely reported. That such...
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Detection of T Follicular Helper Cells and T Follicular Regulatory Cells in Experimental Sjögren’s Syndrome
With the compiling studies on the autoimmune pathogenesis in the develo** of Sjögren’s syndrome, the functional importance of T follicular helper...
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Cytokine expression profiles in white blood cells of patients with small fiber neuropathy
BackgroundThe role of cytokines in the pathophysiology, diagnosis, and prognosis of small fiber neuropathy (SFN) is incompletely understood. We...
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What are the current anti-COVID-19 drugs? From traditional to smart molecular mechanisms
BackgroundCoronavirus disease 19 (COVID-19) is the disease caused by SARS-CoV-2, a highly infectious member of the coronavirus family, which emerged...
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The therapeutic age of the neonatal Fc receptor
IgGs are essential soluble components of the adaptive immune response that evolved to protect the body from infection. Compared with other...
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Transfer of patient’s peripheral blood mononuclear cells (PBMCs) disrupts blood–brain barrier and induces anti-NMDAR encephalitis: a study of novel humanized PBMC mouse model
BackgroundAnti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune neuropsychiatric disease. Brain access of anti-NMDAR...
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Correlation analysis between auto-immunological and mutational profiles in myelodysplastic syndromes
Objective and designSystemic-Inflammatory-Autoimmune-Diseases (SIAD) is increasingly considered in Myelodysplastic-Syndromes (MDS). In this line, we...
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Novel Mutation in the Moesin (MSN) Gene Leads to Immunodeficiency with Epstein–Barr Virus (EBV) Infection and Dermatomyositis-Like Symptoms
PurposeMoesin (MSN) deficiency is a recently reported combined immunodeficiency, and few cases have been reported to date. We describe a Chinese...
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Recombinant IFN-γ1b Treatment in a Patient with Inherited IFN-γ Deficiency
PurposeInborn errors of IFN-γ immunity underlie Mendelian susceptibility to mycobacterial disease (MSMD). Twenty-two genes with products involved in...
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Immunogenetics of Lupus Erythematosus
Lupus erythematosus (LE) is a heterogeneous disease with a wide range of manifestations ranging from localized lesions in cutaneous lupusCutaneous...