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Increasing prevalence of malaria and acute dengue virus coinfection in Africa: a meta-analysis and meta-regression of cross-sectional studies
BackgroundMalaria and dengue fever are the leading causes of acute, undifferentiated febrile illness. In Africa, misdiagnosis of dengue fever as...
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Genomic insights into Plasmodium vivax population structure and diversity in central Africa
BackgroundThough Plasmodium vivax is the second most common malaria species to infect humans, it has not traditionally been considered a major human...
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Association of body composition with odds of breast cancer by molecular subtype: analysis of the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study
BackgroundThe association between obesity and breast cancer (BC) has been extensively studied among US, European and Asian study populations, with...
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Evolutionary history of Plasmodium vivax and Plasmodium simium in the Americas
Malaria is a vector-borne disease caused by protozoan parasites of the genus Plasmodium . Plasmodium vivax is the most prevalent human-infecting...
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A systematic review and meta-analysis of circulating adhesion molecules in rheumatoid arthritis
BackgroundThe availability of robust biomarkers of endothelial activation might enhance the identification of subclinical atherosclerosis in...
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Attitudes among South African university staff and students towards disclosing secondary genetic findings
The present study represents an initial step in understanding diverse academic perspectives on the disclosure of secondary findings (SFs) from...
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Antimicrobial resistance preparedness in sub-Saharan African countries
BackgroundAntimicrobial resistance (AMR) is of growing concern globally and AMR status in sub-Saharan Africa (SSA) is undefined due to a lack of...
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Evolutionary and functional analyses of LRP5 in archaic and extant modern humans
BackgroundThe human lineage has undergone a postcranial skeleton gracilization (i.e. lower bone mass and strength relative to body size) compared to...
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Mosquito control by abatement programmes in the United States: perspectives and lessons for countries in sub-Saharan Africa
Africa and the United States are both large, heterogeneous geographies with a diverse range of ecologies, climates and mosquito species diversity...
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Tick communities of cattle in smallholder rural livestock production systems in sub-Saharan Africa
BackgroundThe majority of the African population lives in rural areas and depends on agriculture for their livelihoods. To increase the productivity...
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A New Species of Elianella Vercammen-Grandjean (Trombidiformes: Trombiculidae) from the Insular Equatorial Guinea with a Key to the Species into this Genus
PurposeThe African continent has 452 chiggers (Trombidiformes: Trombiculidae) in 61 genera. One of these, Elianella Vercammen-Grandjean, 1956, has...
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Network Expansion and Disease Spread along the Former and Present Straits of the Silk Road(S) and Other International Straits
The term Silk Road was created in the Middle Ages for a rather low spectrum of streets (roads) being used to transport goods from China to Europe and...
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Looking ahead: ethical and social challenges of somatic gene therapy for sickle cell disease in Africa
Somatic gene therapy will be one of the most exciting practices of genetic medicine in Africa and is primed to offer a “new life” for persons living...
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Dissecting the low morbidity and mortality during the COVID-19 pandemic in Africa: a critical review of the facts and fallacies
Except for South Africa, Africa recorded very low cases of coronavirus disease-19 (COVID-19), and even lower deaths compared to other regions of the...
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Subregional origins of emerging SARS-CoV-2 variants during the second pandemic wave in Côte d’Ivoire
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increased transmissibility, virulence and immune escape abilities have...
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A feasible molecular diagnostic strategy for rare genetic disorders within resource-constrained environments
Timely and accurate diagnosis of rare genetic disorders is critical, as it enables improved patient management and prognosis. In a...
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Meta-analysis of the global distribution of clinically relevant CYP2C8 alleles and their inferred functional consequences
BackgroundCYP2C8 is responsible for the metabolism of 5% of clinically prescribed drugs, including antimalarials, anti-cancer and anti-inflammatory...
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Zero malaria: a mirage or reality for populations of sub-Saharan Africa in health transition
The global burden of malaria continues to be a significant public health concern. Despite advances made in therapeutics for malaria, there continues...
