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Single cell lineage tracing reveals clonal dynamics of anti-EGFR therapy resistance in triple negative breast cancer
BackgroundMost primary Triple Negative Breast Cancers (TNBCs) show amplification of the Epidermal Growth Factor Receptor (EGFR) gene, leading to...
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Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disease characterized by adaptive immune system activation, formation of...
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Immunotherapies for Cancer: Bi-specific T Cell Engagers (BiTEs)
Bi-specific T cell engagers (BiTEs) are immunologically active molecules with dual specificity, concurrently binding to a tumor-associated antigen...
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Adaptive immune resistance at the tumour site: mechanisms and therapeutic opportunities
Tumours employ various tactics to adapt and eventually resist immune attack. These mechanisms are collectively called adaptive immune resistance...
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A survey of the currently known mast cell mediators with potential relevance for therapy of mast cell-induced symptoms
Mast cells (MCs) occupy a central role in immunological as well as non-immunological processes as reflected in the variety of the mediators by which...
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Immune Checkpoint Therapy: A New Opportunity for Cancer Treatment
Due to improved understanding of the tumor biology and immunology, cancer immunotherapy has rapidly developed as a promising strategy to treat...
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Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential
Mesenchymal stem cells (MSCs) are multipotent stromal cells that can be obtained from various human tissues and organs. They can differentiate into a...
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Immunotherapy and immunoengineering for breast cancer; a comprehensive insight into CAR-T cell therapy advancements, challenges and prospects
BackgroundBreast cancer (BC) is a highly prevalent solid cancer with a high-rise infiltration of immune cells, turning it into a significant...
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Cancer Stem Cell as a Target for Immunotherapeutic Approach
In today’s world, immunotherapy is known as revolutionary in cancer treatment. Until now, many clinical trials tried to find different targets for...
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Adaptive immune changes associate with clinical progression of Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is the most frequent cause of dementia. Recent evidence suggests the involvement of peripheral immune cells in the...
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Immunogenic cell death in cancer: concept and therapeutic implications
Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune...
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Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses — a randomized, placebo-controlled clinical trial
The gut microbiome can modulate systemic inflammation and is therefore target for immunomodulation. Immunomodulating effects of EDP1815, a bacterial...
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Predictability of B cell clonal persistence and immunosurveillance in breast cancer
B cells and T cells are important components of the adaptive immune system and mediate anticancer immunity. The T cell landscape in cancer is well...
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Pancreatic cancer acquires resistance to MAPK pathway inhibition by clonal expansion and adaptive DNA hypermethylation
BackgroundPancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis. It is marked by extraordinary resistance to...
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Clinical potential of PD-1/PD-L1 blockade therapy for renal cell carcinoma (RCC): a rapidly evolving strategy
Programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade therapy has become a game-changing therapeutic approach revolutionizing the...
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Rewiring innate and adaptive immunity with TLR9 agonist to treat osteosarcoma
BackgroundOsteosarcoma (OS) is the most common primary bone tumor in children and adolescent. Surgery and multidrug chemotherapy are the standard of...
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T-Cell Exhaustion in Cancers
There are different concepts that relate to T-cell hyporesponsivity, such as ignorance, tolerance, anergy, aging, and exhaustion. Among these, T-cell...
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Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and response-adaptive treatment
BackgroundHuman papillomavirus (HPV)-associated oropharyngeal cancer (OPC) has a favorable prognosis which has led to efforts to de-intensify...
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ROS, Redox Regulation, and Anticancer Therapy
This chapter entitled “ROS, Redox Regulation, and Anticancer Therapy” includes all redox-regulated cancer therapy events. Here in this chapter...
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Macrophages as tools and targets in cancer therapy
Tumour-associated macrophages are an essential component of the tumour microenvironment and have a role in the orchestration of angiogenesis,...
