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Actin-depolymerizing factor from Eimeria tenella promotes immunogenic function of chicken dendritic cells
Dendritic cells play a crucial role in inducing antigen-specific immunity to pathogens. During host-parasite interaction, host immune response to the...
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Ascofuranone suppresses invasion and F-actin cytoskeleton organization in cancer cells by inhibiting the mTOR complex 1 signaling pathway
PurposeAscofuranone is an antiviral antibiotic that is known to exert multiple anti-tumor effects, including cell cycle arrest, inhibition of...
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Quantitative Investigation of Neuroprotective Role of ROR1 in a Cell Culture Model of Alzheimer’s Disease
Cytoskeletal and microtubule atrophy are major hallmarks of Alzheimer’s disease (AD). A method to investigate endogenous proteins that can...
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Effects of cytochalasin D on relaxation process of skinned taenia cecum and carotid artery from guinea pig
Actin linked regulatory mechanisms are known to contribute contraction/relaxation in smooth muscle. In order to clarify whether modulation of...
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Association of mRNA Expression Levels of LRP1 and Actin-Binding Proteins with the Development of Laryngeal and Laryngopharyngeal Squamous Cell Carcinoma
We analyzed the association of the level of mRNA expression of the main endocytosis receptor LRP1 and actin-binding proteins (ezrin, profilin-1,...
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Ketamine and Other Glutamate Receptor Antagonists As Fast-Actin
The glutamate hypothesis of depression was prominently emerging in this decade. Evidence has shown that low-dose ketamine infusion or intranasal...
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Monitoring Cell Cytoskeleton Variations upon Piezoelectric Stimulation: Implications for the Immune System
Piezoelectric stimulation can have a significant impact on different cellular functions with possible applications in several fields, such as...
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Actin Polymerization in Apicomplexan A Structural, Functional and Evolutionary Analysis
This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in...
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Rat corneal endothelial cell migration during wound repair on the basement membrane depends more on the PI-3K pathway than the cdc-42 pathway or actin stress fibers
Following a central transcorneal circular freeze injury, organ-cultured rat corneal endothelial cells surrounding the wound reorganize peripheral...
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Coronavirus and the Cytoskeleton of Virus-Infected Cells
The cytoskeleton, which includes actin filaments, microtubules, and intermediate filaments, is one of the most important networks in the cell and...
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Common and unique mechanisms of filamentous actin formation by viruses of the genus Orthorubulavirus
We previously found that infection with human parainfluenza virus type 2 (hPIV-2), a member of the genus Orthorubulavirus, family Paramyxoviridae ,...
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A yeast based assay establishes the pathogenicity of novel missense ACTA2 variants associated with aortic aneurysms
The ACTA2 gene codes for alpha-smooth muscle actin, a critical component of the contractile apparatus of the vascular smooth muscle cells. Autosomal...
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Defining the Assembleome of the Respiratory Syncytial Virus
During respiratory syncytial virus (RSV) particle assembly, the mature RSV particles form as filamentous projections on the surface of RSV-infected...
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Lattice complex assembled by noncompetitive anti-EGFR antibodies regulates actin cytoskeletal reorganization
BackgroundRecent evidence of clinical trials highlights that the combination of two noncompetitive anti-EGFR antibodies can benefit patients with...
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Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling
Restenosis after angioplasty is caused usually by neointima formation characterized by aberrant vascular smooth muscle cell (VSMC) dedifferentiation....
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PTBP1 plays an important role in the development of gastric cancer
BackgroundPolypyrimidine tract binding protein 1 (PTBP1) has been found to play an important role in the occurrence and development of various...
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Assessment of Invadopodium Formation and Gelatin Degradation in Vitro
Some cancer cells form highly regulated structures, termed invadopodia, which mediate local, enzymatic degradation of extracellular matrix and...
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Biochemistry of the Contractile Proteins of Smooth Muscle
Muscle contraction at the molecular level is a process named cross-bridge cycle or actomyosin ATPase cycle resulting from the interaction of myosin...