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Glycosylation-related genes mediated prognostic signature contribute to prognostic prediction and treatment options in ovarian cancer: based on bulk and single‑cell RNA sequencing data
BackgroundOvarian cancer (OC) is a complex disease with significant tumor heterogeneity with the worst prognosis and highest mortality among all...
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New insights into the ambivalent role of YAP/TAZ in human cancers
Hippo signaling was first identified in Drosophila as a key controller of organ size by regulating cell proliferation and anti-apoptosis. Subsequent...
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Fat Fighting Microbes
Obesity still remains a growing epidemic health problem worldwide. Studies have demonstrated that intestinal microbiota performs a very essential...
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Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds
BackgroundDomesticated pigs serve as an ideal animal model for biomedical research and also provide the majority of meat for human consumption in...
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Single-cell aggrephagy-related patterns facilitate tumor microenvironment intercellular communication, influencing osteosarcoma progression and prognosis
Osteosarcoma, a common malignant tumor in children, has emerged as a major threat to the life and health of pediatric patients. Presently, there are...
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Ligand-activated PPARδ expression promotes hepatocellular carcinoma progression by regulating the PI3K-AKT signaling pathway
BackgroundPeroxisome proliferator-activated receptor-beta/delta (PPARδ) was considered as the key regulator involved in the evolution of various...
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CNS tumor stroma transcriptomics identify perivascular fibroblasts as predictors of immunotherapy resistance in glioblastoma patients
Excessive deposition of extracellular matrix (ECM) is a hallmark of solid tumors; however, it remains poorly understood which cellular and molecular...
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Role of Distinct Fat Depots in Metabolic Regulation and Pathological Implications
People suffering from obesity and associated metabolic disorders including diabetes are increasing exponentially around the world. Adipose tissue...
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A m6A methyltransferase-mediated immune signature determines prognosis, immune landscape and immunotherapy efficacy in patients with lung adenocarcinoma
BackgroundAs the most abundant modification in mRNA, the N 6 -methyladenosine (m 6 A) RNA modification is involved in the occurrence and development of...
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Pathological phenotypes of astrocytes in Alzheimer’s disease
Astrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an...
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Beyond Death: Unmasking the Intricacies of Apoptosis Escape
Apoptosis, or programmed cell death, maintains tissue homeostasis by eliminating damaged or unnecessary cells. However, cells can evade this process,...
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Neurovascular abnormalities in retinopathy of prematurity and emerging therapies
Blood vessels in the develo** retina are formed in concert with neural growth, resulting in functional neurovascular network. Disruption of the...
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Nuclear Receptors in Energy Metabolism
Nuclear receptors are master regulators of energy metabolism through the conversion of extracellular signals into gene expression signatures. The...
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Exosomes in the lung cancer microenvironment: biological functions and potential use as clinical biomarkers
Lung cancer is one of the most common malignant tumours worldwide. however, emerging immunotherapy and targeted therapies continue to show limited...
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lncRNA FGD5-AS1 is required for gastric cancer proliferation by inhibiting cell senescence and ROS production via stabilizing YBX1
BackgroundThe vast majority of lncRNAs have low expression abundance, which greatly limits their functional range and impact. As a high expression...
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Genome Editing in Dyslipidemia and Atherosclerosis
Despite successive advancement of genome editing technology with zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases...
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Distal Onco-Sphere: Molecular Mechanisms in Metastasis
Although there has been some hint in important molecular mechanisms in metastasis, this process is incompletely understood. We now understood the...
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Exome sequence analysis identifies rare coding variants associated with a machine learning-based marker for coronary artery disease
Coronary artery disease (CAD) exists on a spectrum of disease represented by a combination of risk factors and pathogenic processes. An in silico...
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The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers
The biology of breast cancer response to neoadjuvant therapy is underrepresented in the literature and provides a window-of-opportunity to explore...
