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Biological target volume based on fluorine-18-fluorode-oxyglucose positron emission tomography/computed tomography imaging: a spurious proposition?
PurposeTo assess whether the high metabolic region of fluorine-18-fluorode-oxyglucose ( 18 F-FDG) in the primary lesion is the crux for recurrence in...
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Neuroimaging in Frontotemporal Lobar Degeneration: Research and Clinical Utility
Frontotemporal lobar dementia (FTLD) is a clinically and pathologically complex disease. Advances in neuroimaging techniques have provided a...
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DARS2 overexpression is associated with PET/CT metabolic parameters and affects glycolytic activity in lung adenocarcinoma
BackgroundThis study investigated the correlation between the expression of DARS2 and metabolic parameters of 18 F-FDG PET/CT, and explored the...
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ImmunoPET Imaging of Immune Checkpoints to Assess Their Cancer Therapeutic Potential
Cancer immunotherapy treatments have shown promising results in several clinical trials and have demonstrated beneficial therapeutic outcomes even in...
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Probable Novel APP Met671Leu Mutation in a Chinese Han Family with Early-Onset Alzheimer’s Disease
Familial Alzheimer’s disease (AD) is a rare disease caused by autosomal-dominant mutations. APP (encoding amyloid precursor protein), PSEN1 (encoding...
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Disrupting Na+ ion homeostasis and Na+/K+ ATPase activity in breast cancer cells directly modulates glycolysis in vitro and in vivo
BackgroundGlycolytic flux is regulated by the energy demands of the cell. Upregulated glycolysis in cancer cells may therefore result from increased...
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Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by 18F-FDG PET in patients with a recent ischemic stroke
Background18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) identifies carotid plaque inflammation and predicts stroke recurrence.
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High GLUT1 membrane expression and low PSMA membrane expression in Ductal Adenocarcinoma and Intraductal Carcinoma of the prostate
BackgroundBoth Ductal Adenocarcinoma (DAC) and Intraductal Carcinoma (IDC) of the prostate are generally associated with aggressive clinical behavior...
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Exploring the neuroprotective effects of montelukast on brain inflammation and metabolism in a rat model of quinolinic acid-induced striatal neurotoxicity
BackgroundOne intrastriatal administration of quinolinic acid (QA) in rats induces a lesion with features resembling those observed in Huntington’s...
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A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer’s disease
BackgroundEffective, disease-modifying therapeutics for the treatment of Alzheimer’s disease (AD) remain a large unmet need. Extensive evidence...
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Advances in PET imaging of cancer
Molecular imaging has experienced enormous advancements in the areas of imaging technology, imaging probe and contrast development, and data quality,...
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Retrospective analysis of the 18F-FDG PET/CT cutoff value for metabolic parameters was performed as a prediction model to evaluate risk factors for endometrial cancer
PurposeThe study retrospectively analyzed the accuracy and predictive ability of preoperative integrated whole-body 18 F-FDG PET/CT for the...
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Radiomics analysis of bone marrow biopsy locations in [18F]FDG PET/CT images for measurable residual disease assessment in multiple myeloma
The combination of visual assessment of whole body [ 18 F]FDG PET images and evaluation of bone marrow samples by Multiparameter Flow Cytometry (MFC)...
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Autophagy inhibition improves the targeted radionuclide therapy efficacy of 131I-FAP-2286 in pancreatic cancer xenografts
PurposesRadiotherapy can induce tumor cell autophagy, which might impair the antitumoral effect. This study aims to investigate the effect of...
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124I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies
Extracellular matrix metalloproteinase inducer CD147 is a glycoprotein on the cell surface. There is minimal expression of CD147 in normal epithelial...
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PET/MR imaging of inflammation in atherosclerosis
Myocardial infarction, stroke, mental disorders, neurodegenerative processes, autoimmune diseases, cancer and the human immunodeficiency virus impact...
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Biomarkers and Target-Specific Small-Molecule Drugs in Alzheimer’s Diagnostic and Therapeutic Research: From Amyloidosis to Tauopathy
Alzheimer’s disease (AD) is the most common type of human dementia and is responsible for over 60% of diagnosed dementia cases worldwide. Abnormal...
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Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands
The mammalian brain controls heat generation and heat loss mechanisms that regulate body temperature and energy metabolism. Thermoeffectors include...
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A dual tracer [11C]PBR28 and [18F]FDG microPET evaluation of neuroinflammation and brain energy metabolism in murine endotoxemia
BackgroundBrain metabolic alterations and neuroinflammation have been reported in several peripheral inflammatory conditions and present significant...
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18F-FDG PET and a classifier algorithm reveal a characteristic glucose metabolic pattern in adult patients with moyamoya disease and vascular cognitive impairment
Vascular cognitive impairment (VCI) is a critical issue in moyamoya disease (MMD). However, the glucose metabolic pattern in these patients is still...
