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Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine kinases that are activated by dual phosphorylation on threonine and...
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Phosphorylation State-Specific Antibodies
Over the past four decades, studies directed toward the elucidation of mechanisms involved in the hormonal regulation of metabolism have burgeoned... -
Ras-mediated cell proliferation and cell death: some clues from the interleukin-2 receptor system
Oncoproteins of the Ras family have been extensively studied because of their implication in human cancer. Their roles have been primarily assigned...
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The role of apoptosis in neurodegenerative diseases
Apoptosis is a single word that describes the complex contortions of the membrane and organelles of a cell as it goes through the process of... -
Role of GTP-Binding Proteins in FcεRI Signaling
Direct evidence for the involvement of specific GTPases in the response of mast cells or the related rat basophilic leukemia (RBL-2H3) cells to FcεRI... -
Apoptosis: A current molecular analysis
Apoptosis is a cell suicide program characterized by distinct morphological (cell shrinkage, membrane blebbirig, pyknosis, chromatin margination....
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Mechanisms of Growth Factor-Mediated Signal Transduction in PC12 Cells
One of the most important and pressing issues in developmental neurobiology is understanding how neurons are generated from uncommitted precursor... -
IL-6 cytokine family and signal transduction: a model of the cytokine system
The interleukin 6 (IL-6) cytokine family, which includes IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor...