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Dyshomeostasis of Iron and Its Transporter Proteins in Cypermethrin-Induced Parkinson’s Disease
The etiology of Parkinson’s disease (PD) is highly complex and is still indefinable. However, a number of studies have indicated the involvement of...
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Plasma transferrin and hemopexin are associated with altered Aβ uptake and cognitive decline in Alzheimer’s disease pathology
BackgroundHeme and iron homeostasis is perturbed in Alzheimer’s disease (AD); therefore, the aim of the study was to examine the levels and...
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Anti-TIM3 chimeric antigen receptor-natural killer cells from engineered induced pluripotent stem cells effectively target acute myeloid leukemia cells
BackgroundAcute myeloid leukemia (AML) is a clonal malignant disorder which originates from a small number of leukemia-initiating cells or leukemic...
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Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate hyperglycemia, which causes endothelial dysfunction and...
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Ligand Targeted Polymeric Nanoparticles for Cancer Chemotherapy
Cancer induces various types of tumors that affects every body part. Effective cancer-targeted therapy involves the use of site-specific drugs...
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Nutrition impact on ILC3 maintenance and function centers on a cell-intrinsic CD71–iron axis
Iron metabolism is pivotal for cell fitness in the mammalian host; however, its role in group 3 innate lymphoid cells (ILC3s) is unknown. Here we...
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Increased IL-6 Levels and the Upregulation of Iron Regulatory Biomarkers Contribute to the Progression of Japanese Encephalitis Virus Infection’s Pathogenesis
Integrated analysis of iron regulatory biomarkers and inflammatory response could be an important strategy for Japanese encephalitis viral (JEV)...
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Loss of Brca1 and Trp53 in adult mouse mammary ductal epithelium results in development of hormone receptor-positive or hormone receptor-negative tumors, depending on inactivation of Rb family proteins
BackgroundBreast cancer is a heterogenous disease with several histological and molecular subtypes. Models that represent these subtypes are...
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OX26-cojugated gangliosilated liposomes to improve the post-ischemic therapeutic effect of CDP-choline
Cerebrovascular impairment represents one of the main causes of death worldwide with a mortality rate of 5.5 million per year. The disability of 50%...
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Novel pathogenic variants in CUBN uncouple proteinuria from renal function
BackgroundProteinuria is an unfavorable clinical condition highly associated with a risk of renal and cardiovascular disease in chronic kidney...
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The differences in drug disposition gene induction by rifampicin and rifabutin are unlikely due to different effects on important pregnane X receptor (NR1I2) splice variants
Rifampicin and rifabutin can activate the pregnane X receptor (PXR, NR1I2 ), thereby inducing pharmacokinetically important genes/proteins and...
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Transferrin Receptor Targeted Cellular Delivery of Doxorubicin Via a Reduction-Responsive Peptide-Drug Conjugate
PurposeTransferrin receptors (TfRs) are overexpressed in tumor cells but are scarce in normal tissues, which makes TfR an attractive target for drug...
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Expression and subcellular localization of Discoidin Domain Receptor 1 (DDR1) define prostate cancer aggressiveness
BackgroundThe Discoidin Domain Receptor 1 (DDR1) is one of the two members of a unique family of receptor tyrosine kinase receptors that signal in...
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Bifenthrin Caused Parkinson’s-Like Symptoms Via Mitochondrial Autophagy and Ferroptosis Pathway Stereoselectively in Parkin−/− Mice and C57BL/6 Mice
It has been proposed that pyrethroid exposure contributes to the increasing prevalence of neurodegenerative diseases. However, the potential...
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Effects of iron homeostasis on epigenetic age acceleration: a two-sample Mendelian randomization study
BackgroundEpigenetic clocks constructed from DNA methylation patterns have emerged as excellent predictors of aging and aging-related health...
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A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD), suggesting that activation of this innate immune...
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Ligand Conjugated Polymeric Micelles for Targeted Delivery of Drug Payloads in Cancer Therapy
Therapeutics can be delivered to specific areas in the body using ligand conjugated polymeric micelles. Both passive and active targeting methods can...
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Targeted nano-delivery of chemotherapy via intranasal route suppresses in vivo glioblastoma growth and prolongs survival in the intracranial mouse model
Nanotechnology-based drug delivery platforms have shown great potential in overcoming the limitations of conventional therapy for glioblastoma (GBM)....
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N-Acetyl Serotonin Provides Neuroprotective Effects by Inhibiting Ferroptosis in the Neonatal Rat Hippocampus Following Hypoxic Brain Injury
Hypoxic-ischemic encephalopathy is the main cause of infant brain damage, perinatal death, and chronic neonatal disability worldwide. Ferroptosis is...
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Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation
BackgroundAlzheimer’s disease (AD) is the most common type of neurodegenerative disease in the contemporary era, and it is still clinically...
