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An Introduction to Phosphoinositides
Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This...
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Endocrine Disorders with Potentially Fatal Outcome
Endocrine causes of sudden death are relatively rare compared to other internal causes. Thus, they may not be considered at autopsy and thus go...
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Channelopathies linked to plasma membrane phosphoinositides
The plasma membrane phosphoinositide phosphatidylinositol 4,5-bisphosphate (PIP 2 ) controls the activity of most ion channels tested thus far through...
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Thyrotoxic cardiomyopathy and encephalopathy in a paraplegic man
Study design:Case report.
Background/objective:Thyrotoxicosis complicating spinal cord injury is more common than generally appreciated. To raise...
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Skeletal remodeling in health and disease
The use of genetically manipulated mouse models, gene and protein discovery and the cataloguing of genetic mutations have each allowed us to obtain...
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Hypokalemic periodic paralysis: A model for a clinical and research approach to a rare disorder
Rare diseases have attracted little attention in the past from physicians and researchers. The situation has recently changed for several reasons....
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Selenium, deiodinases and endocrine function
The three iodothyronine deiodinases catalyze the initiation (D1, D2) and termination (D3) of THyroid hormone effects in vertebrates. A 3-dimensional...
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Development of Lymphopoiesis as a Function of the Thymic Microenvironment
Previous thymic studies detected a subcapsular A2B5 + and Thy-1+, TE4+, Vimentin+, Cytokeratin+, so-called “endocrine” RE...
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Skeletal Muscle and Nerve-Muscle Junction
Skeletal muscles are the major ending of the efferent branch of the central nervous system. We work our will upon the outside world through these...
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Kardiomyopathien — genetische Ursachen und Pathogenese
Als Kardiomyopathien werden Krankheiten des Herzmuskels bezeichnet, die zu einer Beeinträchtigung der systolischen und/oder diastolischen Funktion...
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Amiodarone and the Thyroid
Amiodarone was synthesized in 1961 by Tondeur and Binon in the Labaz Laboratories in Belgium. It is a benzofuran derivative related to the obsolete...
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Fucus Vesiculosus and Allied Brown Algae
The term ‘focus’ was originally used in a non-specific sense to describe the higher algae [1]. This has led to misleading accounts in the literature...
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Molecular Biology of Thyroid Hormone Action
The major biologically active thyroid hormone 3,5,3’-triiodothyronine (T3) exerts effects upon almost every cell and tissue of the body influencing...
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Endocrinology
The effect of steroid and peptide hormones as well as the influence of drugs on the endocrine system can be detected by repeated administration of...