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Vaccination and Multiple Sclerosis – Current Situation
Active immunization of patients with autoimmune diseases is a current challenge. Vaccination of patients with multiple sclerosis (MS) has been shown...
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Congruent microbiome signatures in fibrosis-prone autoimmune diseases: IgG4-related disease and systemic sclerosis
BackgroundImmunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc) are rare autoimmune diseases characterized by the presence of CD4+...
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Autophagy in Multiple Sclerosis: Phagocytosis and Autophagy of Oligodendrocyte Precursor Cells
Multiple sclerosis (MS) is a leading cause of chronic neurological dysfunction in young to middle-aged adults, affecting approximately 2.5 million...
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Association between MEF2 family gene polymorphisms and susceptibility to multiple sclerosis in Chinese population
PurposeMultiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelinating lesions in the white matter of the central...
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Humoral immune response and safety of Sars-Cov-2 vaccine in people with multiple sclerosis
BackgroundFor the past three years, the pandemic has had a major effect on global public health, mainly on those with underlying medical conditions,...
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Excitotoxicity and Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the progressive and selective death of motor neurons...
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Tissue-resident immune cells in the pathogenesis of multiple sclerosis
BackgroundMultiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) in which genetic and environmental...
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Tyrosine Kinases: Targets for Epigenetic Influences and a New Direction in the Treatment of Multiple Sclerosis
Studies have shown that tyrosine kinases (TK) may play an important role in the pathogenesis of multiple sclerosis (MS) operating through a microRNA...
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The Search for Immunological Biomarkers in Type 1 Diabetes Mellitus (T1DM) and Multiple Sclerosis (MS): Th40 Cells Provide a Common Autoimmune Link
Biomarkers to predict autoimmune disease onset or predict progression are sorely lacking. A specific T cell subset present in peripheral blood of...
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Acupuncture Treatment for Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system, which affected millions of patients worldwide with no...
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Therapeutic potential of exosomes derived from mesenchymal stem cells for treatment of systemic lupus erythematosus
Autoimmune diseases are caused by an imbalance in the immune system, producing autoantibodies that cause inflammation leading to tissue damage and...
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Immune responses following COVID-19 infection in multiple sclerosis patients using immunomodulatory therapy
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus type-2 (SARS-CoV-2), has quickly become a global...
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A Drug–Drug Interaction Study to Investigate the Effect of Nintedanib on the Pharmacokinetics of Microgynon (Ethinylestradiol and Levonorgestrel) in Female Patients with Systemic Sclerosis-Associated Interstitial Lung Disease
Background and ObjectivesNintedanib is a tyrosine kinase inhibitor approved for the treatment of systemic sclerosis-associated interstitial lung...
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The Role of Gut-derived Short-Chain Fatty Acids in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic condition affecting the central nervous system (CNS), where the interplay of genetic and environmental factors...
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Infection-Induced Systemic Inflammation and Dementia
It has long been recognized that there exists a unique interaction between the peripheral immune system and the brain, an interaction that is...
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Pathogenic Role of Fibrinogen in the Neuropathology of Multiple Sclerosis: A Tale of Sorrows and Fears
Multiple sclerosis (MS) is an autoimmune demyelinating neurodegenerative disease of the central nervous system (CNS) due to injury of the myelin...
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Roles and regulation of microglia activity in multiple sclerosis: insights from animal models
As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory lesions and associated neural dysfunctions. In multiple...
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Involvement of gut microbiota in multiple sclerosis—review of a new pathophysiological hypothesis and potential treatment target
Multiple sclerosis (MS) is a chronic inflammatory disease that leads to demyelination and damage to the central nervous system. It is well known, the...
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Broadening our understanding of genetic risk for scleroderma/systemic sclerosis by querying the chromatin architecture surrounding the risk haplotypes
BackgroundGenetic variants in the human leukocyte antigen (HLA) locus contribute to the risk for develo** scleroderma/systemic sclerosis (SSc)....
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Sirtuins and Metabolism Biomarkers in Relapsing-Remitting and Secondary Progressive Multiple Sclerosis: a Correlation Study with Clinical Outcomes and Cognitive Impairments
Multiple sclerosis (MS) is a primary inflammatory demyelinating disease with different clinical courses and subtypes. The present study aimed to...
