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Electrical and Morphological Properties of Develo** Motoneurons in Postnatal Mice and Early Abnormalities in SOD1 Transgenic Mice
In this chapter, we review electrical and morphological properties of lumbar motoneurons during postnatal development in wild-type (WT) and...
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Investigating the pharmacological potential of phytol on experimental models of gastric ulcer in rats
Phytol is a diterpene constituent of many essential oils, belonging to the group of unsaturated acyclic alcohols. Although phytol possesses...
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Oxidative Stress and Metals in Alzheimer’s Disease
Alzheimer’s disease (AD) is one of the progressive neurodegenerative disorders allied with genetic, lifestyle, and environmental factors and mainly...
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Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
BackgroundIntratumor subsets with tumor-initiating features in glioblastoma are likely to survive treatment. Our goal is to identify the key factor...
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Melatonin counteracts aluminum-induced affective and cognitive disorders and oxidative damage in male wistar rats
Aluminum (Al) is a potentially toxic element causing many neuropathological and behavioral alterations such as affective and cognitive disorders....
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Simultaneous Exposure to Noise and Toluene Induces Oxidative and Inflammatory Damage in the Heart of Wistar Rats: Therapeutic Potential of Olea europaea L. Leaf Extract
Workers in occupational settings often face simultaneous exposure to multiple risk factors, including noise and chemicals. This study aimed to...
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Molecular effects of photodynamic therapy with curcumin on Leishmania major promastigotes
Leishmaniasis is a neglected disease mainly affecting low-income populations. Conventional treatment involves several side effects, is expensive,...
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Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis
BackgroundA subset of familial forms of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene coding Cu/Zn-superoxide dismutase...
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In Vivo Intracerebral Administration of α-Ketoisocaproic Acid to Neonate Rats Disrupts Brain Redox Homeostasis and Promotes Neuronal Death, Glial Reactivity, and Myelination Injury
Maple syrup urine disease (MSUD) is caused by severe deficiency of branched-chain α-keto acid dehydrogenase complex activity, resulting in tissue...
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SOD1-Related Cerebellar Ataxia and Motor Neuron Disease: Cp Variant as Functional Modifier?
We describe a novel superoxide dismutase ( SOD1 ) mutation-associated clinical phenotype of cerebellar ataxia and motor neuron disease with a variant...
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Evidence for causal effects of polycystic ovary syndrome on oxidative stress: a two-sample mendelian randomisation study
BackgroundPolycystic ovary syndrome (PCOS) is often accompanied by increased oxidative stress levels; however, it is still unclear whether PCOS...
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The Cysteine (Cys) Residues Cys-6 and Cys-111 in Mutant Superoxide Dismutase 1 (SOD1) A4V Are Required for Induction of Endoplasmic Reticulum Stress in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the degeneration of motor neurons. Between 12 and 20% of...
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Host-parasite interaction in severe and uncomplicated malaria infection in ghanaian children
PurposeDuring malarial infection, both parasites and host red blood cells (RBCs) come under severe oxidative stress due to the production of free...
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Curcumin attenuates brain aging by reducing apoptosis and oxidative stress
Brain aging is a physiological event, and oxidative stress and apoptosis are involved in the natural aging process of the brain. Curcumin is a...
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Aspartame, as an artificial sweetener, does not affect renal function and antioxidative states in mice
Background and objectiveAspartame ( l -aspartyl l -phenylalanine methyl ester) is an artificial sweetener widely used as a sugar substitute. There are...
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Alpha-Pinene Alleviates Motor Activity in Animal Model of Huntington’s Disease via Enhancing Antioxidant Capacity
Huntington’s disease (HD) is a progressive, neurodegenerative, and inherited disease. Antioxidants have been shown to be effective in slowing disease...
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In vivo antioxidant activity of rabbiteye blueberry (Vaccinium ashei cv. ‘Brightwell’) anthocyanin extracts
Blueberries are rich in phenolic compounds including anthocyanins which are closely related to biological health functions. The purpose of this study...
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Doxorubicin Cytotoxicity in Differentiated H9c2 Cardiomyocytes: Evidence for Acute Mitochondrial Superoxide Generation
Although a mitochondrial redox-cycling superoxide-generating mechanism for the cardiotoxicity of doxorubicin was suggested from experiments with...
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Topical application of synthetic melanin promotes tissue repair
In acute skin injury, healing is impaired by the excessive release of reactive oxygen species (ROS). Melanin, an efficient scavenger of radical...
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Modulatory effect of Justicia secunda leaf extract on hematological status, lipid profile, liver function and oxidative stress in Wistar rats
Justicia secunda is a therapeutic plant with acclaimed beneficial health effects including blood-boosting potential. However, scientific evidence...
