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A review on the synthesis of bio-based surfactants using green chemistry principles
ObjectivesWith increasing awareness of the potential adverse impact of conventional surfactants on the environment and human health, there is...
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Modulation of cellular transcriptome and proteome composition by azidohomoalanine—implications on click chemistry–based secretome analysis
AbstractThe analysis of the secretome provides important information on proteins defining intercellular communication and the recruitment and...
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Recent Development on Sensing Strategies for Small Molecules Detections
Sensors play a critical role in the detection and monitoring of various substances present in our environment, providing us with valuable information...
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Small Catalytic RNA
RNA catalyze biochemical reactions. The endonucleolytic small RNA can cut their own phosphodiester linkages at specific sites. These autocatalytic...
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Antimicrobial Peptides and Small Molecules as Antibiotics Substitute
Despite a century of the discovery of first natural antimicrobial peptide (AMP), lysozyme, their development as clinical candidates has not...
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Targeting RNA structures with small molecules
RNA adopts 3D structures that confer varied functional roles in human biology and dysfunction in disease. Approaches to therapeutically target RNA...
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A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance
BackgroundRett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked methyl-CpG binding protein 2 ( MeCP2 ) gene. While MeCP2...
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Impacts of age, type 2 diabetes, and hypertension on circulating neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 after prolonged work in the heat in men
PurposeProlonged work in the heat increases the risk of acute kidney injury (AKI) in young men. Whether aging and age-associated chronic disease may...
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Nanomedicine-mediated alteration of the pharmacokinetic profile of small molecule cancer immunotherapeutics
The advent of immunotherapy is a game changer in cancer therapy with monoclonal antibody- and T cell-based therapeutics being the current flagships....
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Artificial intelligence-powered discovery of small molecules inhibiting CTLA-4 in cancer
Background/ObjectivesCheckpoint inhibitors, which generate durable responses in many cancer patients, have revolutionized cancer immunotherapy....
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Plant Secondary Metabolites: An Introduction of Their Chemistry and Biological Significance with Physicochemical Aspect
Nature is the immense source of chemical compounds or substances usually acknowledged as natural products. Plants are the considerable source of an...
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Pharmacologic profile of ITI-333: a novel molecule for treatment of substance use disorders
RationaleMedications are urgently needed to treat symptoms of drug withdrawal and mitigate dysphoria and psychiatric comorbidities that drive opioid...
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Efficacy of Synthetic Organic Molecule Inhibitors of TRAF2 and NCK-Interacting Kinase (TNIK) Against Colorectal Cancer
Kinases are widely regarded as the principal biocatalysts that drive many anomalies in cancer. Tumorigenesis is characterized by proliferation of...
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Efficacy of Synthetic Organic Molecule Inhibitors of TRAF2 and NCK-Interacting Kinase (TNIK) Against Colorectal Cancer
Kinases are widely regarded as the principal biocatalysts that drive many anomalies in cancer. Tumorigenesis is characterized by proliferation of...
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The small-molecule protein ligand interface stabiliser E7820 induces differential cell line specific responses of integrin α2 expression
BackgroundThe mechanism of small-molecule stabilised protein-protein interactions is of growing interest in the pharmacological discovery process. A...
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Green and Sustainable Chemistry as Regulatory Levers
The increasing environmental pollution, industrial accidents and chemical-induced exposures, and resulting disease led to the concept of a green...
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Engineered Materials for Probing and Perturbing Brain Chemistry
Neurons are the functional and structural building blocks of the brain and the nervous system and they are programmed to receive and process sensory...
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Chemical Biology of Extracellular Vesicles
During the initial phases of extracellular vesicle (EV) research, researchers faced many obstacles, including a lack of standard methods for the...
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Discovery of sultam-containing small-molecule disruptors of the huntingtin–calmodulin protein–protein interaction
The aberrant protein–protein interaction between calmodulin and mutant huntingtin protein in Huntington’s disease patients has been found to...
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Green and Sustainable Chemistry as Regulatory Levers
The increasing environmental pollution, industrial accidents and chemical-induced exposures, and resulting disease led to the concept of a green...