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Estrogen Receptor Alpha and ESR1 Mutations in Breast Cancer
The estrogen receptor alphaEstrogen receptor alpha (ERα) is a nuclear transcriptionTranscription factor that is expressed in more than 70% of all...
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Bacterial endotoxin lipopolysaccharides regulate gene expression in human colon cancer cells
ObjectiveLipopolysaccharide (LPS) is a major cell wall component of gram-negative bacteria. Colon bacteria contribute to LPS which promotes colon...
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Directing the Way—Receptor and Chemical Targeting Strategies for Nucleic Acid Delivery
Nucleic acid therapeutics have shown great potential for the treatment of numerous diseases, such as genetic disorders, cancer and infections....
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Increased trunk fat is associated with altered gene expression in breast tissue of normal weight women
Increased trunk fat is associated with an elevated risk of breast cancer in normal-weight postmenopausal women. The main objective of this study was...
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Long-term effects of a fat-directed FGF21 gene therapy in aged female mice
Fibroblast growth factor 21 (FGF21) has been developed as a potential therapeutic agent for metabolic syndromes. Moreover, FGF21 is considered a...
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The glucocorticoid receptor as a master regulator of the Müller cell response to diabetic conditions in mice
Diabetic retinopathy (DR) is considered a primarily microvascular complication of diabetes. Müller glia cells are at the centre of the retinal...
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Biomarkers in Experimental Diabetes: Studies with Syzygium Cumini (L.) and Links with the Sulfonylurea 1 Receptor
Diabetes mellitus (DM) is showing a global rise in its incidence. Pancreatic beta cell dysfunction, insulin resistance, and inflammation contribute...
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Advances in the research and application of neurokinin-1 receptor antagonists
Recently, the substance P (SP)/neurokinin-1 receptor (NK-1R) system has been found to be involved in various human pathophysiological disorders...
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Intra-abdominal adipose depot variation in adipogenesis, lipogenesis, angiogenesis, and fibrosis gene expression and relationships with insulin resistance and inflammation in premenopausal women with severe obesity
Although severe obesity is associated with insulin resistance (IR) and inflammation, secretory function of intra-abdominal adipose tissues and their...
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Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus
The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic...
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Leptin Contributes to Neuropathic Pain via Extrasynaptic NMDAR-nNOS Activation
Leptin is an adipocytokine that is primarily secreted by white adipose tissue, and it contributes to the pathogenesis of neuropathic pain in...
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Plasma Leptin Reflects Progression of Neurofibrillary Pathology in Animal Model of Tauopathy
The close relationship between Alzheimer’s disease (AD) and obesity was recognized many years ago. However, complete understanding of the...
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Adenosine receptor A1 enhanced mitochondrial biogenesis and exerted neuroprotection after cerebral ischemia through PGC-1α
Ischemic stroke is a common cause of morbidity and mortality worldwide. The current treatment fails to achieve satisfactory results, because...
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Lectures 9 and 10: Endocrine System & Hormones
The Endocrine System consists the following organs: Hypothalamus, pituitary (anterior & posterior parts), pineal, thyroid, 4 parathyroids, thymus,...
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The Effect of Polymorphisms of Energy Metabolism Genes on Metabolic Disorders in Overweight Adolescents of Two Ethnicities
The aim of this cross-sectional observational study is to determine the contribution of polymorphisms of energy metabolism genes into metabolic...
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Dietary interventions in mice affect oxidative stress and gene expression of the Prlr and Esr1 in the adipose tissue and hypothalamus of dams and their offspring
Maternal diet is key to the progeny’s health since it may impact on the offspring’s adult life. In this study, mice dams received standard (CONT),...
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Identification and Validation of CXCL2 as a Key Gene for Childhood Obesity
This study aims to identify the key genes and their regulatory networks by bioinformatics, increasing understanding of childhood obesity. The data...
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Palm-based tocotrienol-rich fraction (TRF) supplementation modulates cardiac sod1 expression, fxr target gene expression, and tauro-conjugated bile acid levels in aleptinemic mice fed a high-fat diet
Tocotrienol-rich fraction (TRF) has been reported to protect the heart from oxidative stress-induced inflammation. It is, however, unclear whether...
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Pilot Study of the DRD3, GHRL, FTO, LEPR, INSIG2, GSTP1, and ABCB1 Gene Expression in Peripheral Blood Leukocytes in Schizophrenic Patients with Metabolic Syndrome
Abstract —Many individuals with schizophrenia also suffer from metabolic syndrome (MetS), which is a major risk factor for the development of...
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Multi-faceted Anti-obesity Effects of N-Methyl-D-Aspartate (NMDA) Receptor Modulators: Central-Peripheral Crosstalk
Hypothalamus is central to food intake and satiety. Recent data unveiled the expression of N-methyl-D-aspartate receptors (NMDAR) on hypothalamic...
