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Nanotechnology-based theranostic and prophylactic approaches against SARS-CoV-2
SARS-CoV-2 (COVID-19) pandemic has been an unpredicted burden on global healthcare system by infecting over 700 million individuals, with...
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Traditional Medical System (TMS) for Sustainable Healthcare in India
Traditional medicine has a long history. The World Health Organization (WHO) recognizes that traditional medicine (TM) is a vital part of the global...
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Lactobacillus reuteri improves the development and maturation of fecal microbiota in piglets through mother-to-infant microbe and metabolite vertical transmission
BackgroundThe immature neonatal fecal microbiota substantially impacts the development of gut health and greatly increases the risk of disease....
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Demonstration of Physicochemical and Functional Similarity of the Biosimilar BAT1806/BIIB800 to Reference Tocilizumab
Background and ObjectiveTocilizumab is an immunoglobulin G1 monoclonal antibody targeting the interleukin-6 receptor (IL-6R). BAT1806/BIIB800...
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Integrated transcriptomic and proteomic analyses of plerocercoid and adult Spirometra mansoni reveal potential important pathways in the development of the medical tapeworm
BackgroundSpirometra mansoni can parasitize animals and humans through food and water, causing parasitic zoonosis. Knowledge of the developmental...
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Current trends and future directions for the synthesis and pharmacological applications of 2-(2-cyanopyrrolidin-1-yl)-N-3-hydroxyadamantan-1-yl) acetamide (Gliptins)
Dipeptidyl peptidase 4 (DPP-4), well known as the T-cell antigen CD26 enzyme which, was discovered in the year of 1966 by Hopsu-Havu and Glenner. The...
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Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays—and how this matters for the harm potential of seized drugs
Cultivation of industrial low-Δ 9 -tetrahydrocannabinol (Δ 9 -THC) hemp has created an oversupply of cannabidiol (CBD)-rich products. The fact that...
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Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques
An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date have suggested the need to...
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Immunogenicity and Vaccines of Polysaccharides
There is an increased interest in the use of plant extracts as therapeutic agents exploring their ability to inhibit growth of pathogenic...
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Traditional Medicine Stability and Pharmacokinetic Issue
Phytomedicine including Ayurveda, Siddha, Naturopathy, Homeopathy, Chinese traditional medicine, Unani, etc. has a long history of therapeutic...
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Identification of a novel gene signature predicting response to first-line chemotherapy in BRCA wild-type high-grade serous ovarian cancer patients
BackgroundHigh-grade serous ovarian cancer (HGSOC) has poor survival rates due to a combination of diagnosis at advanced stage and disease recurrence...
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Migration of styrene oligomers from food contact materials: in silico prediction of possible genotoxicity
Styrene oligomers (SO) are well-known side products formed during styrene polymerization. They consist mainly of dimers (SD) and trimers (ST) that...
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“Waste Not, Want Not” — Leveraging Sewer Systems and Wastewater-Based Epidemiology for Drug Use Trends and Pharmaceutical Monitoring
During the current global COVID-19 pandemic and opioid epidemic, wastewater-based epidemiology (WBE) has emerged as a powerful tool for monitoring...
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Identification of Lysine Misincorporation at Asparagine Position in Recombinant Insulin Analogs Produced in
E. coli PurposeIdentification of human insulin analogs’ impurity with a mass shift +14 Da in comparison to a parent protein.
MethodsThe protein sequence...
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6-Color Crystal Digital PCRTM for the High-Plex Detection of EGFR Mutations in Non-Small Cell Lung Cancer
The profiling of EGFR mutations, the most common genetic alterations in non-small cell lung cancer (NSCLC) predictive of targeted therapy efficacy,...
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Development and Evaluation of Stable Long Circulating Decitabine-loaded Copolymeric Nanoparticles: Harnessing QbD Approach and Lyophilization Technique
PurposeDecitabine is an inhibitor of DNA methyltransferase used to treat various types of leukemias. However, it is highly unstable in nature thereby...
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Antimalarial drug discovery: progress and approaches
Recent antimalarial drug discovery has been a race to produce new medicines that overcome emerging drug resistance, whilst considering safety and...
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Bioapplications of Nanomaterials
Nanobiotechnology is known as the application of nanoscaled techniques in biology which bridges natural science to living organism for improving the...
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Pharmacology and Toxicology Concerns of Impurities
Botanical drugsBotanical drugs are complex mixturesComplex mixtures of natural constituents with potential for product impuritiesImpurities that...
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An expanding horizon of complex injectable products: development and regulatory considerations
There has been a constant evolution in the pharmaceutical market concerning the new technologies imbibed in delivering drug substances for various...
