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Impact of age on the cerebrospinal fluid spaces: high-convexity and medial subarachnoid spaces decrease with age
BackgroundImpaired cerebrospinal fluid (CSF) dynamics may contribute to the pathophysiology of neurodegenerative diseases, and play a crucial role in...
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Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients
BackgroundA growing body of evidence suggests that the accumulation of amyloid-β and tau (HPτ) in the brain of patients with the dementia subtype...
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Secondary deterioration in patients with normal pressure hydrocephalus after ventriculoperitoneal shunt placement: a proposed algorithm of treatment
BackgroundAfter ventriculoperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (iNPH) with adjustable gravitational valves, a...
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Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders
BackgroundQuantitative measurements of cerebrospinal fluid to blood clearance has previously not been established for neurological diseases....
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Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques
BackgroundAlzheimer’s disease (AD) is the most common neurodegenerative disease and type 2 diabetes (T2D) plays an important role in conferring the...
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Cerebrospinal fluid dynamics in non-acute post-traumatic ventriculomegaly
BackgroundPost-traumatic hydrocephalus (PTH) is potentially under-diagnosed and under-treated, generating the need for a more efficient diagnostic...
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The effects of cerebrospinal fluid tap-test on idiopathic normal pressure hydrocephalus: an inertial sensors based assessment
BackgroundGait disturbances are typical of persons with idiopathic normal pressure hydrocephalus (iNPH) without signs distinctive from other...
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Heterozygous FOXJ1 Mutations Cause Incomplete Ependymal Cell Differentiation and Communicating Hydrocephalus
Heterozygous mutations affecting FOXJ1 , a transcription factor governing multiciliated cell development, have been associated with obstructive...
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The Kuopio idiopathic normal pressure hydrocephalus protocol: initial outcome of 175 patients
BackgroundThe Kuopio University Hospital (KUH) idiopathic normal pressure hydrocephalus (iNPH) cerebrospinal fluid (CSF) shunting protocol is...
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The role of astrocytes in the glymphatic network: a narrative review
To date, treatment of Central Nervous System (CNS) pathology has largely focused on neuronal structure and function. Yet, revived attention towards...
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Enlarged Perivascular Space and Index for Diffusivity Along the Perivascular Space as Emerging Neuroimaging Biomarkers of Neurological Diseases
The existence of lymphatic vessels or similar clearance systems in the central nervous system (CNS) that transport nutrients and remove cellular...
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Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies
Cerebrospinal fluid (CSF) is an essential and critical component of the central nervous system (CNS). According to the concept of the “third...
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Paradigm-shift: radiological changes in the asymptomatic iNPH-patient to be: an observational study
BackgroundMany radiological signs are known for the diagnosis of idiopathic normal pressure hydrocephalus (iNPH). However, there is little...
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Alzheimer’s disease neuropathological change and loss of matrix/neuropil in patients with idiopathic Normal Pressure Hydrocephalus, a model of Alzheimer’s disease
Here, we assessed unique brain tissue samples, obtained from living subjects with idiopathic Normal Pressure Hydrocephalus (iNPH). Our cohort of 95...
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Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"
The Hydrocephalus Association (HA) workshop, Driving Common Pathways: Extending Insights from Posthemorrhagic Hydrocephalus, was held on November 4...
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Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases
BackgroundSeveral central nervous system diseases are associated with disturbed cerebrospinal fluid (CSF) flow patterns and have typically been...
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Comorbidity of diabetes mellitus in idiopathic normal pressure hydrocephalus: a systematic literature review
Idiopathic normal pressure hydrocephalus (iNPH) is a subtype of hydrocephalus that occurs more often in the elderly population. It is usually...
