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Diagnostic and prognostic value of plasma neurofilament light and total-tau in sporadic Creutzfeldt-Jakob disease
BackgroundBlood neurofilament light (Nfl) and total-tau (t-tau) have been described to be increased in several neurological conditions, including...
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Regulatory roles of N6-methyladenosine (m6A) methylation in RNA processing and non-communicable diseases
Post-transcriptional RNA modification is an emerging epigenetic control mechanism in cells that is important in many different cellular and...
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Advances in the Genetics of Human Tremor
This chapter aims at describing the recent advances in the genetics of human tremor. Several human disorders are characterized by tremor as one of... -
Using Small Molecules for Targeting Heavy Metals in Neurotoxicity and Neuroinflammation
Pharmaceutical drugs, natural toxins, industrial chemicals, and various environmental toxins negatively impact the nervous system. A significant... -
Challenging management of severe chronic disorders in acute pandemic situation: Chronic liver disease under COVID-19 pandemic as the proof-of-principle model to orchestrate the measures in 3PM context
Chronic liver disease management is a comprehensive approach requiring multi-professional expertise and well-orchestrated healthcare measures...
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Sex and nest type influence avian blood parasite prevalence in a high-elevation bird community
BackgroundThe prevalence of avian haemosporidian parasites and the factors influencing infection in the Colorado Rocky Mountains are largely unknown....
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Liver Disease Modelling
The liver is not only the main metabolic organ of the body and responsible for storing and providing nutrients, it is also the largest gland,... -
Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity
Anti-tuberculosis (AT) medications, including isoniazid (INH), can cause drug-induced liver injury (DILI), but the underlying mechanism remains...
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Consensus Paper: Novel Directions and Next Steps of Non-invasive Brain Stimulation of the Cerebellum in Health and Disease
The cerebellum is involved in multiple closed-loops circuitry which connect the cerebellar modules with the motor cortex, prefrontal, temporal, and...
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Potential Role of Brain-Derived Neurotrophic Factor and Dopamine Receptor D2 Gene Variants as Modifiers for the Susceptibility and Clinical Course of Wilson’s Disease
Wilson’s disease (WD), an inborn error of copper metabolism caused by mutations in the ATPase copper transporting beta ( ATP7B ) gene, manifests...
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Intrinsic low-frequency oscillation changes in multiple-frequency bands in stable patients with chronic obstructive pulmonary disease
Abnormal local spontaneous brain activity during the resting state has been observed in chronic obstructive pulmonary disease (COPD). However, it is...
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Mitochondrial Dysfunction: A Key Player in the Pathogenesis of Autism Spectrum Disorders and Alzheimer’s Disease
Increasing evidence has pinpointed that loss of mitochondrial function or regulation is a critical player toward the pathogenesis of various... -
Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease
ObjectiveThe occurrence of non-alcoholic fatty liver disease (NAFLD) is globally increasing. To challenge the current incidence of NAFLD,...
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Essential Tremor and Other Forms of Kinetic Tremor
Kinetic tremor is a tremor (i.e., a rhythmic and oscillatory movement) that occurs during guided voluntary movements like writing or touching finger... -
Diagnosis of malaria in pregnancy: accuracy of CareStart™ malaria Pf/PAN against light microscopy among symptomatic pregnant women at the Central Hospital in Yaoundé, Cameroon
BackgroundThe need to start treatment early for pregnant women who present with clinical features of malaria usually conflicts with the need to...