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Utility of A2L2 score in acute ischemic stroke patient triage: the “H.uni” experience
Background and aimsTwo or more National Institutes of Health Stroke Scale (NIHSS) points on each motor items (A 2 L 2 score) have shown good accuracy...
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Dynamic Detection of Thrombolysis in Embolic Stroke Rats by Synchrotron Radiation Angiography
A rodent model of embolic middle cerebral artery occlusion is used to mimic cerebral embolism in clinical patients. Thrombolytic therapy is the...
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Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites
Hemorrhagic transformation (HT) is a common serious complication of stroke after thrombolysis treatment, which limits the clinical use of tissue...
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The impact of COVID-19 on acute stroke care in Belgium
A worldwide decline in stroke hospitalizations during the COVID-19 pandemic has been reported. Information on stroke care during the pandemic in...
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Clinical Significance and Influencing Factors of Microvascular Tissue Reperfusion After Macrovascular Recanalization
The relevance of impaired microvascular tissue reperfusion despite successful macrovascular angiographic reperfusion (no-reflow) in acute ischemic...
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Granulocytes-Rich Thrombi in Cerebral Large Vessel Occlusion Are Associated with Increased Stiffness and Poorer Revascularization Outcomes
We aim to identify a profile of intracranial thrombus resistant to recanalization by mechanical thrombectomy (MT) in acute stroke treatment. The...
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LncRNAs: Promising Therapeutic Targets and Biomarkers for Ischemic Stroke
Ischemic stroke is one of the leading causes of mortality and disability worldwide. Currently, options for ischemic stroke clinical therapy remain...
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Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability
The impairment of blood-brain barrier (BBB) integrity is the pathological basis of hemorrhage transformation and vasogenic edema following...
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The Safety and Efficacy of Endovascular Treatment in Acute Ischemic Stroke Patients Caused by Large-Vessel Occlusion with Different Etiologies of Stroke: Data from ANGEL-ACT Registry
This study aimed to investigate the safety and efficacy of endovascular treatment (EVT) in acute ischemic stroke (AIS) patients caused by...
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Clinical Pharmacokinetics and Pharmacodynamics of Desmoteplase
Desmoteplase is a bat ( Desmodus rotundus ) saliva-derived fibrinolytic enzyme resembling a urokinase and tissue plasminogen activator. It is highly...
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Interaction between stroke severity and quality indicators of acute stroke care: a single-center retrospective analysis
Ischemic stroke leads to substantial mortality and morbidity worldwide. Door-to-CT time, door-to-needle time (DNT), and door-to-groin time (DGT) are...
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Ultrasound-responsive polymer-based drug delivery systems
Ultrasound-responsive polymeric materials have received a tremendous amount of attention from scientists for several decades. Compared to other...
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Lactate dehydrogenase A mediated histone lactylation induced the pyroptosis through targeting HMGB1
Cerebral ischemia (CI), as the cerebrovascular disease with the highest incidence rate, is treated by limited intravenous thrombolysis and...
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Prognostic capacity of hyperdense middle cerebral artery sign in anterior circulation acute ischaemic stroke patients receiving reperfusion therapy: a systematic review and meta-analysis
Pre-intervention CT imaging-based biomarkers, such as hyperdense middle cerebral artery sign (HMCAS) may have a role in acute ischaemic stroke...
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Red Blood Cells in the Cerebrospinal Fluid Compartment After Subarachnoid Haemorrhage: Significance and Emerging Therapeutic Strategies
Subarachnoid haemorrhage (SAH) is a subtype of stroke that predominantly impacts younger individuals. It is associated with high mortality rates and...
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Recent Advances and Therapeutic Implications of 2-Oxoglutarate-Dependent Dioxygenases in Ischemic Stroke
Ischemic stroke is a common disease with a high disability rate and mortality, which brings heavy pressure on families and medical insurance....
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Safety Outcomes of Antiplatelet Therapy During Endovascular Treatment of Tandem Lesions in Acute Ischemic Stroke Patients
Risk of hemorrhage remains with antiplatelet medications required with carotid stenting during endovascular therapy (EVT) for tandem lesion (TLs). We...
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Adjunctive cytoprotective therapies in acute ischemic stroke: a systematic review
With the introduction of endovascular thrombectomy (EVT), a new era for treatment of acute ischemic stroke (AIS) has arrived. However, despite the...
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Phthalide derivative CD21 attenuates tissue plasminogen activator-induced hemorrhagic transformation in ischemic stroke by enhancing macrophage scavenger receptor 1-mediated DAMP (peroxiredoxin 1) clearance
BackgroundHemorrhagic transformation (HT) is a critical issue in thrombolytic therapy in acute ischemic stroke. Damage-associated molecular pattern...
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Evolving Stroke Systems of Care: Stroke Diagnosis and Treatment in the Post-Thrombectomy Era
Thrombectomy became the gold-standard treatment of acute ischemic stroke caused by large-vessel occlusions (LVO) in 2015 after five clinical trials...